Scaffolds modified with graphene as future implants for nasal cartilage

Rajzer, I.; Kurowska, Anna; Jabłoński, Adam; Kwiatkowski, Ryszard; Piekarczyk, Wojciech; Hajduga, M.; Kopeć, J.; Sidzina, Marcin; Menaszek, E.

doi:10.1007/s10853-019-04298-7

Cited by 22 publications

(21 citation statements)

References 29 publications

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“…Then, PCL and FLG powders were properly cryomilled in a 6,770 SPEX Freezer/mill resulting in a composite powder of PCL and 0.5 wt% of fG(Micrograf). The choice of 0.5 wt% filler content in the composite was based on several previous studies that reported successful composite scaffold production and good cellular behavior with this graphene content 25‐29 …”

Section: Methodsmentioning

confidence: 99%

“…The choice of 0.5 wt% filler content in the composite was based on several previous studies that reported successful composite scaffold production and good cellular behavior with this graphene content. [25][26][27][28][29] Based on previous studies to mitigate possible re-agglomeration effects during the freezing step of the cryomilling process, 30 a protocol was implemented based on 10 min pre-cooling in liquid nitrogen and 20 min of continuous milling per cycle. After this procedure, the composite powder was collected and kept in a sealed container, ready for 3D printing.…”

Section: Fabrication Of 3d-printed Scaffoldsmentioning

confidence: 99%

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3D‐printed cryomilled poly(ε‐caprolactone)/graphene composite scaffolds for bone tissue regeneration

et al. 2020

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In this study, composite scaffolds based on poly(caprolactone) (PCL) and non‐covalently functionalized few‐layer graphene (FLG) were manufactured by an extrusion‐based system for the first time. For that, functionalized FLG powder was obtained through the evaporation of a functionalized FLG aqueous suspension prepared from a graphite precursor. Cryomilling was shown to be an efficient mixing method, producing a homogeneous dispersion of FLG particles onto the PCL polymeric matrix. Thereafter, fused deposition modeling (FDM) was used to print 3D scaffolds and their morphology, thermal, biodegradability, mechanical, and cytotoxicity properties were analysed. The presence of functionalized FLG demonstrated to induce slight changes in the microstructure of the scaffold, did not affect the thermal stability and enhanced significantly the compressive modulus. The composite scaffolds presented a porosity of around 40% and a mean pore size in the range of 300 μm. The cell viability and proliferation of SaOs‐2 cells were assessed and the results showed good cell viability and long‐term proliferation onto produced composite scaffolds. Therefore, these new FLG/PCL scaffolds comprised adequate morphological, thermal, mechanical, and biological properties to be used in bone tissue regeneration.

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Section: Methodsmentioning

confidence: 99%

Section: Fabrication Of 3d-printed Scaffoldsmentioning

confidence: 99%

3D‐printed cryomilled poly(ε‐caprolactone)/graphene composite scaffolds for bone tissue regeneration

et al. 2020

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“…The cartilage growth on the 3D-printed GO scaffold was thicker than that on the 3D-printed scaffold without GO, which confirmed GO potential for a cartilage matrix [83]. Rajzer et al [84] utilized a 3D printing process to produce a polycaprolactone (PCL)/graphene (GR) scaffolds with antimicrobial properties using short filament sticks. New filament materials with GR nanoplatelets in concentration of 0.5, 5, and 10 wt% were prepared using injection molding.…”

Section: Nanomaterials For Cartilage Healing and Regenerationmentioning

confidence: 94%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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“…3D printing can be achieved using photopolymerization (stereolithography, material jetting, and two-photon polymerization), extrusion (fused deposition modeling, robocasting), powder-based (selective/selective inhibition laser sintering, selective laser melting, binder jetting, and electron beam melting), laminated object manufacturing, and direct ink techniques [ 177 , 178 , 179 ]. Graphene–polymer for 3D printing has attracted great attention in biomedical applications, tissue engineering [ 180 ], and scaffolds [ 180 , 181 , 182 , 183 , 184 ]. Bioprinting has two types, the pre-seeding or direct method, and the post-seeding or indirect method [ 185 ].…”

Section: Applicationsmentioning

confidence: 99%

“…Using the injection process, 3D scaffolds in the form of sticks were prepared with PCL–graphene nanoplatelets. These sticks were proposed as nasal cartilage [ 183 ]. Polylactic acid with GO was used to prepare scaffolds and the prepared scaffolds were proposed for bone formation applications [ 184 ].…”

Section: Applicationsmentioning

confidence: 99%

Recent Studies on Dispersion of Graphene–Polymer Composites

2021

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Graphene is an excellent 2D material that has extraordinary properties such as high surface area, electron mobility, conductivity, and high light transmission. Polymer composites are used in many applications in place of polymers. In recent years, the development of stable graphene dispersions with high graphene concentrations has attracted great attention due to their applications in energy, bio-fields, and so forth. Thus, this review essentially discusses the preparation of stable graphene–polymer composites/dispersions. Discussion on existing methods of preparing graphene is included with their merits and demerits. Among existing methods, mechanical exfoliation is widely used for the preparation of stable graphene dispersion, the theoretical background of this method is discussed briefly. Solvents, surfactants, and polymers that are used for dispersing graphene and the factors to be considered while preparing stable graphene dispersions are discussed in detail. Further, the direct applications of stable graphene dispersions are discussed briefly. Finally, a summary and prospects for the development of stable graphene dispersions are proposed.

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Scaffolds modified with graphene as future implants for nasal cartilage

Cited by 22 publications

References 29 publications

3D‐printed cryomilled poly(ε‐caprolactone)/graphene composite scaffolds for bone tissue regeneration

3D‐printed cryomilled poly(ε‐caprolactone)/graphene composite scaffolds for bone tissue regeneration

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Recent Studies on Dispersion of Graphene–Polymer Composites

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