Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Serrano‐Aroca, Ãngel; Cano-Vicent, Alba; Serra, Roser Sabater i; El‐Tanani, Mohamed; Aljabali, AlaaAA.; Tambuwala, Murtaza M.; Mishra, Yogendra Kumar

doi:10.1016/j.mtbio.2022.100412

Cited by 47 publications

(33 citation statements)

References 415 publications

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“…Repairing the cartilage defects in the rabbit model by aligned PLLA-polydopamine chondroitin sulfate fibers was facilitated, and cartilage defects were regenerated by hyaline cartilage-like tissue [89]. In light of the foregoing, the application of nanoscaffolds for cartilage restoration is an auspicious approach with a high application potential, which can gain from recent breakthroughs in biomedical engineering [90][91][92][93].…”

Section: The Effect Of Architectural Features Of Scaffolds On Cartila...mentioning

confidence: 99%

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Ahmadian¹,

Eftekhari²,

Janas³

et al. 2023

Nanotheranostics

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Articular cartilage has a low self-repair capacity due to the lack of vessels and nerves. In recent times, nanofiber scaffolds have been widely used for this purpose. The optimum nanofiber scaffold should stimulate new tissue's growth and mimic the articular cartilage nature. Furthermore, the characteristics of the scaffold should match those of the cellular matrix components of the native tissue to best merge with the target tissue. Therefore, selective modification of prefabricated scaffolds based on the structure of the repaired tissues is commonly conducted to promote restoring the tissue. A thorough analysis is required to find out the architectural features of scaffolds that are essential to make the treatment successful. The current review aims to target this challenge. The article highlights different optimization approaches of nanofibrous scaffolds for improved cartilage tissue engineering. In this context, the influence of the architecture of nanoscaffolds on performance is discussed in detail. Finally, based on the gathered information, a future outlook is provided to catalyze development in this promising field.

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Section: The Effect Of Architectural Features Of Scaffolds On Cartila...mentioning

confidence: 99%

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Ahmadian¹,

Eftekhari²,

Janas³

et al. 2023

Nanotheranostics

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“…Among these metal ions, Zn ions have a good antibacterial ability when they reach a certain concentration and can kill various bacteria and fungi. Zinc is an essential element with intrinsic antibacterial and osteoinductive capacity [ 91 ]. Zn-based antimicrobial materials generally consist of zinc complexes and ZnO nano-particles.…”

Section: Biocompatibility Of Zn-based Biodegradable Materialsmentioning

confidence: 99%

Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation

Liu

Qiao

et al. 2022

JFB

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Traditional inert materials used in internal fixation have caused many complications and generally require removal with secondary surgeries. Biodegradable materials, such as magnesium (Mg)-, iron (Fe)- and zinc (Zn)-based alloys, open up a new pathway to address those issues. During the last decades, Mg-based alloys have attracted much attention by researchers. However, the issues with an over-fast degradation rate and release of hydrogen still need to be overcome. Zn alloys have comparable mechanical properties with traditional metal materials, e.g., titanium (Ti), and have a moderate degradation rate, potentially serving as a good candidate for internal fixation materials, especially at load-bearing sites of the skeleton. Emerging Zn-based alloys and composites have been developed in recent years and in vitro and in vivo studies have been performed to explore their biodegradability, mechanical property, and biocompatibility in order to move towards the ultimate goal of clinical application in fracture fixation. This article seeks to offer a review of related research progress on Zn-based biodegradable materials, which may provide a useful reference for future studies on Zn-based biodegradable materials targeting applications in orthopedic internal fixation.

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“…However, one of the most economical and simplest techniques is fused deposition modeling (FDM), which only uses the biomaterial without any cells, , in which the polymer thread is wound around a bobbin and extruded from a nozzle heated to the polymer melt temperature . PLA, which is a cost-effective, degradable sterilizable polymer, capable of being produced in large quantities and customized to individual patient’s requirements, is probably the most common material used in FDM. , PLA-based scaffolds are demonstrated to be very promising for bone tissue engineering applications. − …”

Section: Introductionmentioning

confidence: 99%

Engineering Three-Dimensional-Printed Bioactive Polylactic Acid Alginate Composite Scaffolds with Antibacterial and In Vivo Osteoinductive Capacity

Serra-Aguado

Llorens-Gámez

Vercet-Llopis

et al. 2022

ACS Appl. Mater. Interfaces

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Although fused deposition modeling (FDM) has made it possible to create reproducible three-dimensional poly(lactic acid) (PLA) scaffolds, their efficacy for tissue engineering applications is limited by their lack of osteoinductive properties and antibacterial functions. Building on the success of the FDM constructs capable of supporting bone regeneration, we report here on the development of PLA scaffolds infused with sodium alginate cross-linked with both calcium and zinc divalent cations. Zn 2+ cations were used to confer antibacterial and osteoinductive properties to enhance the performance of nontoxic PLA-alginate. Both the PLA and alginate polymers have been approved by the US Food and Drug Administration. In vivo bone regeneration capacity was demonstrated on a rabbit model by tomography and histological analysis. The scaffolds exhibited antibacterial activity against Gram-positive methicillin-resistant Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa, while the control scaffolds could not resist the two microbial species tested. The scaffolds' physical properties were evaluated by field emission scanning electron microscopy with energy-disperse X-ray spectroscopy, Fourier transform infrared spectroscopy, water absorption, porosity measurements, and compression tests in dry and swollen states at body temperature. Their superior compressive properties, water uptake, and osteoinductive and antibacterial activities thus make them promising candidates for bone tissue regeneration.

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Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

Cited by 47 publications

References 415 publications

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Nanofiber scaffolds based on extracellular matrix for articular cartilage engineering: A perspective

Zinc-Based Biodegradable Materials for Orthopaedic Internal Fixation

Engineering Three-Dimensional-Printed Bioactive Polylactic Acid Alginate Composite Scaffolds with Antibacterial and In Vivo Osteoinductive Capacity

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