Scaffolds for drug delivery and tissue engineering: The role of genetics

Zielińska, Aleksandra; Karczewski, Jacek; Eder, Piotr; Kolanowski, Tomasz; Szalata, Milena; Wielgus, Karolina; Szalata, Marlena; Kim, Dohun; Shin, Su Ryon; Słomski, Ryszard; Souto, Eliana B.

doi:10.1016/j.jconrel.2023.05.042

Cited by 61 publications

(24 citation statements)

References 180 publications

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“…Also, using nanomaterials for scaffolding can greatly improve their performance and interactions in living things because of their very small size and unique make-up. Consequently, it is anticipated that nanomaterial-based scaffolds will emerge as a highly effective approach for OS treatment, bone repair, and regeneration in the future [127]. Sarkar and Bose formulated 3D-printed porous CaP scaffolds loaded with liposomal curcumin to increase its bioavailability.…”

Section: Polymeric and Liposomal Nps-based Tissue Engineered Scaffoldsmentioning

confidence: 99%

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu,

Lekhavadhani,

Miranda

et al. 2024

Biomed. Mater.

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Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery systems. Surgical resection of OS leaves a critical bone defect requiring medical intervention. Recently, tissue engineered scaffolds have been reported to provide physical support to bone defects and aid multimodal treatment of OS. These scaffolds loaded with nanoparticulate delivery systems could also actively repress tumor growth and aid new bone formation. The rapid developments in nanotherapeutics and bone tissue engineering have paved the way for improved treatment efficacy for OS-related bone defects. This review focuses on current bifunctional nanomaterials-based tissue engineered scaffolds that use novel approaches such as magnetic hyperthermia, photodynamic therapy, photothermal therapy, bioceramic and polymeric nanotherapeutics against OS. With further optimization and screening, nanomaterials-based tissue engineered scaffolds could meet clinical applications for treating OS patients.

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Section: Polymeric and Liposomal Nps-based Tissue Engineered Scaffoldsmentioning

confidence: 99%

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu,

Lekhavadhani,

Miranda

et al. 2024

Biomed. Mater.

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“…FGF, in particular, supports the development of new blood vessels, aids in repairing damaged ECs, and promotes their migration . In the future, the combination of scaffolds and liposomes may lead to the creation of self-assembled drug carrier systems, offering promising prospects for tissue regeneration and disease treatment. , …”

Section: Multifaceted Effects Of Biomaterials Enhance Endothelial Cel...mentioning

confidence: 99%

“…95 In the future, the combination of scaffolds and liposomes may lead to the creation of self-assembled drug carrier systems, offering promising prospects for tissue regeneration and disease treatment. 116,117 4.1. The Influence of Physicochemical Properties of Surface in the Context of Endothelial Cell Behavior.…”

Section: Multifaceted Effects Of Biomaterials Enhance Endothelial Cel...mentioning

confidence: 99%

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Unraveling Endothelial Cell Migration: Insights into Fundamental Forces, Inflammation, Biomaterial Applications, and Tissue Regeneration Strategies

Jerka,

Bonowicz,

Piekarska

et al. 2024

ACS Appl. Bio Mater.

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Cell migration is vital for many fundamental biological processes and human pathologies throughout our life. Dynamic molecular changes in the tissue microenvironment determine modifications of cell movement, which can be reflected either individually or collectively. Endothelial cell (EC) migratory adaptation occurs during several events and phenomena, such as endothelial injury, vasculogenesis, and angiogenesis, under both normal and highly inflammatory conditions. Several advantageous processes can be supported by biomaterials. Endothelial cells are used in combination with various types of biomaterials to design scaffolds promoting the formation of mature blood vessels within tissue engineered structures. Appropriate selection, in terms of scaffolding properties, can promote desirable cell behavior to varying degrees. An increasing amount of research could lead to the creation of the perfect biomaterial for regenerative medicine applications. In this review, we summarize the state of knowledge regarding the possible systems by which inflammation may influence endothelial cell migration. We also describe the fundamental forces governing cell motility with a specific focus on ECs. Additionally, we discuss the biomaterials used for EC culture, which serve to enhance the proliferative, proangiogenic, and promigratory potential of cells. Moreover, we introduce the mechanisms of cell movement and highlight the significance of understanding these mechanisms in the context of designing scaffolds that promote tissue regeneration.

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“…Zielińska et al (2023) stated that drug/tissue delivery scaffolds should choose the appropriate scaffold type in order to influence the material’s architecture and structure (e.g., hydrogels, nanofibers, nanopatterns, microparticles, nanoparticles, or matrix) [ 212 ]. Additionally, the selection and incorporation of bioactive agents (among other cells, proteins, peptides, pharmaceutical molecules) into the scaffold may improve its characteristics.…”

Section: Scaffolds In Bte/rmmentioning

confidence: 99%

Recent Advances in Scaffolds for Guided Bone Regeneration

Valamvanos,

Dereka,

Katifelis

et al. 2024

Biomimetics

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The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool. This article presents a critical consideration in scaffold’s design and development while also providing information on various fabrication methods of these nanosystems. Their utilization as delivery systems will also be mentioned.

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Scaffolds for drug delivery and tissue engineering: The role of genetics

Cited by 61 publications

References 180 publications

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Unraveling Endothelial Cell Migration: Insights into Fundamental Forces, Inflammation, Biomaterial Applications, and Tissue Regeneration Strategies

Recent Advances in Scaffolds for Guided Bone Regeneration

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