Scaffold-based regeneration of skeletal tissues to meet clinical challenges

Li, Jiao Jiao; Kaplan, David L.; Zreiqat, Hala

doi:10.1039/c4tb01073f

Cited by 110 publications

(79 citation statements)

References 455 publications

(601 reference statements)

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“…DCSC scaffolds exhibit the same trend as that for other ceramic materials, where their mechanical strength is inversely proportional to porosity [16]. This creates a significant challenge for the design and fabrication of ceramic scaffolds for use in bone reconstruction.…”

Section: Mechanical Properties Of Solid and Porous Dcscsmentioning

confidence: 99%

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Zreiqat

2017

Materials

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Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the ionic substitution of calcium ions, the incorporation of metal oxides into the base binary xCaO–ySiO2 system, or a combination of both. Due to their unique compositions and ability to release bioactive ions, DCSCs exhibit enhanced mechanical and biological properties. Such characteristics offer significant advantages over existing ceramic bone substitutes, and underline the future potential of adopting DCSCs for clinical use in bone reconstruction to produce improved outcomes. This review will discuss the effects of different dopant elements and oxides on the characteristics of DCSCs for applications in bone repair, including mechanical properties, degradation and ion release characteristics, radiopacity, and biological activity (in vitro and in vivo). Recent advances in the development of DCSCs for broader clinical applications will also be discussed, including DCSC composites, coated DCSC scaffolds and DCSC-coated metal implants.

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Section: Mechanical Properties Of Solid and Porous Dcscsmentioning

confidence: 99%

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Zreiqat

2017

Materials

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“…[1][2][3] Considerable research has been carried out in the area of tissue engineering based regenerative medicine as a promising strategy in the treatment of damaged tissues and organs. [4,5] Tissue engineering has great potential and is likely to have a profound impact in the future. In tissue engineering, a suitable combination of scaffolds, stem cells, and cytokines is required for the treatment of damaged tissues and organs.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Osteogenic Differentiation of Human Dental Pulp Stem Cells Embedded in an Injectable In Vivo‐Forming Hydrogel

Jang

Park

et al. 2016

Macromolecular Bioscience

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In this study, human dental pulp stem cells (hDPSCs) are examined as a cellular source for bone tissue engineering using an in vivo-forming hydrogel. The hDPSCs are easily harvested in large quantities from extracted teeth. The stemness of harvested hDPSCs indicates their relative tolerance to ex vivo manipulation in culture. The in vitro osteogenic differentiation of hDPSCs is characterized using Alizarin Red S (ARS), von Kossa (VK), and alkaline phosphatase (ALP) staining. The solution of hDPSCs and a methoxy polyethylene glycol-polycaprolactone block copolymer (PC) is easily prepared by simple mixing at room temperature and in no more than 10 s it forms in vivo hydrogels after subcutaneous injection into rats. In vivo osteogenic differentiation of hDPSCs in the in vivo-forming hydrogel is confirmed by micro-computed tomography (CT), histological staining, and gene expression. Micro-CT analysis shows evidence of significant tissue-engineered bone formation in hDPSCs-loaded hydrogel in the presence of osteogenic factors. Differentiated osteoblasts in in vivo-forming hydrogel are identified by ARS and VK staining and are found to exhibit characteristic expression of genes like osteonectin, osteopontin, and osteocalcin. In conclusion, hDPSCs embedded in an in vivo-forming hydrogel may provide benefits as a noninvasive formulation for bone tissue engineering applications.

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“…1 The scaffold allows cells to penetrate through the interconnected porous structure and facilitates the growth of cells and supports cell migration, proliferation, and differentiation. In bone tissue engineering, artificial or synthetic scaffold with suitable properties can be used as matrices and serves as a template for the growth of extracellular bone matrix and provides temporary mechanical support during regeneration of diseased or damaged bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Impact and biocompatibility studies on Mg²⁺‐substituted Apatite‐derived 3D porous scaffolds for hard tissue engineering

Ramadas

Nivedha

Mabrouk

et al. 2019

Int J Applied Ceramic Tech

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The objective of this study was to develop Mg2+‐substituted Apatite scaffolds by slip‐casting method. The Apatite scaffolds were prepared as engineering constructs with interconnected pore structure with a pore size of 128‐194 μm range. The physicochemical properties such as crystalline phase, functional group, microstructure, pore size distribution, and elemental compositions of the scaffolds were characterized. The bioactivity of the developed porous scaffolds was investigated in Simulated Body Fluid (SBF) for various time periods (3 and 7 days). In vitro bioactivity results confirm the hydroxyl Apatite layer formation of the scaffolds and results suggest that the developed microporous scaffold could be used as suitable candidates in bone tissue engineering.

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Scaffold-based regeneration of skeletal tissues to meet clinical challenges

Abstract: Scaffold-based tissue engineering strategies are being explored for the management and reconstruction of damaged or diseased skeletal tissues, the effective treatment of which has remained a significant global healthcare challenge.

Cited by 110 publications

References 455 publications

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

In Vivo Osteogenic Differentiation of Human Dental Pulp Stem Cells Embedded in an Injectable In Vivo‐Forming Hydrogel

Impact and biocompatibility studies on Mg²⁺‐substituted Apatite‐derived 3D porous scaffolds for hard tissue engineering

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Scaffold-based regeneration of skeletal tissues to meet clinical challenges

Abstract: Scaffold-based tissue engineering strategies are being explored for the management and reconstruction of damaged or diseased skeletal tissues, the effective treatment of which has remained a significant global healthcare challenge.

Cited by 110 publications

References 455 publications

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

In Vivo Osteogenic Differentiation of Human Dental Pulp Stem Cells Embedded in an Injectable In Vivo‐Forming Hydrogel

Impact and biocompatibility studies on Mg2+‐substituted Apatite‐derived 3D porous scaffolds for hard tissue engineering

Contact Info

Product

Resources

About

Impact and biocompatibility studies on Mg²⁺‐substituted Apatite‐derived 3D porous scaffolds for hard tissue engineering