Scabies, pyoderma and nephritis in Zaria, Nigeria. A clinical and epidemiological study

Whittle, H.C.; Abdullahi, Maryam; Fakunle, F.; Rajkovic, Aleksandar

doi:10.1016/0035-9203(73)90112-0

Cited by 39 publications

(15 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serafrom patients with acute glomerulonephritis. Sera were obtianed from the following groups of patients as soon as possible after the onset of disease: (a) 13 patients from British hospitals with acute nephritis after throat infection; (6) five patients with acute nephritis after throat infection with M-type 2, submitted by Dr B. Anthony, Harbor Hospital, Los Angeles, California, USA (Anthony et al, 1974); (c) five patients with acute nephritis from an approved school in Britain where several other patients had had skin infections due to M-type 58; (d) seven patients with acute nephritis after skin infection with unknown serotypes from Trinidad; (e) 10 patients from Trinidad with acute nephritis after skin infection with type 57 (incident 8-table I); (f) 10 patients from Trinidad with acute nephritis after skin infection with type 60 '(incident 9-table 1); ( g ) four patients in incident 7 who developed nephritis after infection with M-type 2, T-type 8/25/Imp 19 (Dillon et al, 1968); (h) 13 patients with nephritis after skin infection from Zaria, Nigeria (Whittle et al, 1973).…”

Section: Streptococci mentioning

confidence: 99%

The Antibody Responses in Man to Infection with Different Serotypes of Group-a Streptococci

Widdowson

Maxted

Notley

et al. 1974

Journal of Medical Microbiology

View full text Add to dashboard Cite

AFTER infection with a group-A streptococcus, antibodies to a wide variety of extracellular and somatic antigens can be detected in the patient's serum. One of the factors that may influence the magnitude of these responses is the serotype of the infecting strain. It is well established that patients with streptococcal pyoderma have considerably lower titres of anti-streptolysin 0 (ASO) than do patients with streptococcal sore throat, but that titres of anti-deoxyribonuclease B (anti-DNAase B) are often very high in cases of skin infection (Anthony, Perlman and Wannamaker, 1967;Dillon and Reeves, 1969). It is not known to what extent the site of infection is responsible for these differences, but the serotypes that cause pyoderma are in general quite different from those that commonly cause disease of the respiratory tract (see Wannamaker, 1970).Antibody against M protein confers type-specific protection against reinfection with streptococci of the same serotype, and Denny, Perry and Wannamaker (1957) and Siegal, Johnson and Stollerman (1961) found that at least 70% of patients had type-specific antibody to the infecting strain after recovery from streptococcal sore throat. However, the outbreaks that these workers investigated were all caused by M types that did not produce opacity factor (OF), i.e., " OF-negative M-types " (Maxted and Widdowson, 1972). Information on the antibody response in man to infection with OF-positive serotypes is lacking, but vaccines of these types are generally poorly antigenic in rabbits (Gooder, 1961 ;Top and Wannamaker, 1968;Widdowson, Maxted and Grant, 1970).We have shown (Widdowson, Maxted and Pinney, 1971a) that titres of antibody against streptococcal M-associated protein (MAP) are almost invariably high in patients with rheumatic fever, but much less often raised in patients with acute streptococcal glomerulonephritis and in sporadic cases of sore throat. Later, however, we investigated an outbreak of rheumatic fever due to M-type 5 in which a considerable proportion of the patients with uncomplicated sore throat also developed high titres of anti-MAP (Widdowson et al., 1974). We have therefore studied the antibody responses of patients in a number of outbreaks due to known streptococcal types; the sera were examined for ASO, anti-DNAase B, anti-MAP, and M antibody to the supposed infecting serotype. We also examined the sera of several other groups of patients suffering from the non-suppurative sequelae of streptococcal infection of the throat or of the skin, and the sera of groups of supposedly normal persons.

show abstract

Section: Streptococci mentioning

confidence: 99%

The Antibody Responses in Man to Infection with Different Serotypes of Group-a Streptococci

Widdowson

Maxted

Notley

et al. 1974

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Apart from poor antibody response in infants, matters are complicated by the fact that the 84 different serotypes known do not confer cross-protection. Long-term penicillin prophylaxis in sickle-cell disease remains controversial, despite positive experience in the USA [48]. Adaptation of the choice of serotypes contained in the vaccine according to the pattern of serotypes prevalent in other countries could, in theory, easily be undertaken.…”

Section: Control and Preventionmentioning

confidence: 99%

“…Antimicrobial treatment was studied in 301 children with measles and pneumonia in Nigeria [48]. Ninety-seven children with clinically mild pneumonia were divided into a group treated with penicillin and a control group.…”

Section: Measles Pneumoniamentioning

confidence: 99%

Antibiotics in the Tropics

Enenkel¹,

Stille²

1988

View full text Add to dashboard Cite

“…In Trinidad [34] four epi demics of poststreptococcal nephritis have occurred be tween 1952 and 1973. In India too, it continues to be a common problem [35], In the tropics, streptococcal in fection is predominantly present in the skin, often in association with lesions of scabies [36],…”

Section: Poststreptococcal Glomerulonephritismentioning

confidence: 99%