Glomerular Diseases in the Tropics

Spectrum of glomerular diseases - clinico-pathologic observations from a state run tertiary care centre

“…LM and IF were performed in all biopsies. The average glomerular yield was 13 Figure 2]. Among patients with FSGS presenting as NS, the most common was FSGS-NOS variant (88.6%).…”

“…Here NOS variant was predominant 80% followed by tip (10.83%)and perihilar (5.83%) lesion 11 and another reported on 210 biopsies of FSGS , where the NOS variant was seen in 72.5%, and tip lesion, cellular, perihilar, and collapsing variants were seen in 13.5%, 8%, 4%, and 2%, respectively. 13 Most studies have noted that tip lesion and collapsing FSGS are likely to present with nephrotic syndrome, with the collapsing variant much more frequently associated with a reduced GFR. Also, collapsing subgroup tend to have an older age of disease onset (median age 16.5 years) compared to NOS and tip lesions.…”

Spectrum of Nephropathies With Special Reference to Primary Glomerulopathies

“…We did not come across a single case of other secondary gIomerulopathies like polyarteritis, other vasculitis or hemolytic uraemic syndrome as seen in other Indian studies (included in miscellaneous conditions in Table-S). SLE is particularly more common in China, Malyasia and Singapore, less common in white population as such and least in the black Africans [3]. On the other hand amyloidosis is very important cause of secondary ON in India and that too secondary amyloidosis, in contrast to USA where primary amyloidosis is more common.…”

“…On the other hand amyloidosis is very important cause of secondary ON in India and that too secondary amyloidosis, in contrast to USA where primary amyloidosis is more common. Amyloidosis surprisingly is rarely encountered in Africa and West Indies [3]. As far as other nephropathies are concerned, we did not carry out further analysis.…”

“…However while discussing the nephropathies, we usually have limited data about the incidence of these disorders in Indian setup. Few centers have published this data in our country [1][2][3][4]. But it is felt that more studies are required to be published to get a wider database.…”