SBA-15-collagen hybrid material for drug delivery applications

Fagundes, L.B.; Sousa, Taiane; Sousa, Alana Lislea de; Silva, V.V.; Sousa, Edésia Martins Barros de

doi:10.1016/j.jnoncrysol.2006.03.111

Cited by 41 publications

(11 citation statements)

References 15 publications

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“…21 The dried collagen/silica membranes have also been shown to improve in vitro and in vivo bioactivity for use as guiding membranes for bone regeneration. [22][23][24][25][26][27] While the collagen/silica hybrid compositions have been shown to hold potential properties for use in bone repair and regeneration, very few systematic works have been carried out on hybrid hydrogels to encapsulate and cultivate cells for cell delivery and bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of silica-hybridized collagen hydrogels as three-dimensional cell matrices for hard tissue engineering

Lee

Seo

et al. 2015

J Biomater Appl

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Exploiting hydrogels for the cultivation of stem cells, aiming to provide them with physico-chemical cues suitable for osteogenesis, is a critical demand for bone engineering. Here, we developed hybrid compositions of collagen and silica into hydrogels via a simple sol-gel process. The physico-chemical and mechanical properties, degradation behavior, and bone-bioactivity were characterized in-depth; furthermore, the in vitro mesenchymal stem cell growth and osteogenic differentiation behaviors within the 3D hybrid gel matrices were communicated for the first time. The hydrolyzed and condensed silica phase enabled chemical links with the collagen fibrils to form networked hybrid gels. The hybrid gels showed improved chemical stability and greater resistance to enzymatic degradation. The in vitro apatite-forming ability was enhanced by the hybrid composition. The viscoelastic mechanical properties of the hybrid gels were significantly improved in terms of the deformation resistance to an applied load and the modulus values under a dynamic oscillation. Mesenchymal stem cells adhered well to the hybrid networks and proliferated actively with substantial cytoskeletal extensions within the gel matrices. Of note, the hybrid gels substantially reduced the cell-mediated gel contraction behaviors, possibly due to the stiffer networks and higher resistance to cell-mediated degradation. Furthermore, the osteogenic differentiation of cells, including the expression of bone-associated genes and protein, was significantly upregulated within the hybrid gel matrices. Together with the physico-chemical and mechanical properties, the cellular behaviors observed within 3D gel matrices, being different from the previous approaches reported on 2D substrates, provide new information on the feasibility and usefulness of the silica-collagen system for stem cell culture and tissue engineering of hard tissues.

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Section: Introductionmentioning

confidence: 99%

Feasibility of silica-hybridized collagen hydrogels as three-dimensional cell matrices for hard tissue engineering

Lee

Seo

et al. 2015

J Biomater Appl

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“…13 Fagundes et al fabricated biocompatible mesoporous silica-collagen hybrid materials for drug delivery applications. 14 Heinemann et al fabricated bioactive silica/collagen composite xerogels modified by calcium phosphate phases with adjustable mechanical properties for bone replacement. 15 Eglin et al reported in vitro apatite forming ability in type I collagen hydrogels containing bioactive glass and silica sol-gel particles.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of novel collagen-silica hybrid membranes with tailored biodegradation and strong cell contact guidance ability

et al. 2012

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The fabrication of novel collagen-silica hybrid membranes with tailored biodegradation and strong cell contact guidance ability is reported in the present study. Collagen-silica hybrids were first synthesized by reacting 3-glycidoxypropyltrimethoxysilane (GPTMS), which functioned as both the cross-linker and the silica source, with acid-soluble type I porcine collagen monomers. Subsequently, they were coated and dried on the surface of polydimethylsiloxane (PDMS) chips with either flat or microgroove surfaces to produce the corresponding collagen-silica hybrid membrane with a flat or microgroove surface. Scanning electron microscopy images showed that membranes formed on flat PDMS chips exhibited smooth and dense surfaces, while those formed on microgrooved PDMS chips exhibited typical microgroove surfaces with a 10 mm groove width, 8 mm ridge width, and 0.5 mm depth. Despite the difference in surface topography, both flat and microgrooved collagen-silica membranes exhibited stronger resistance against collagenase enzyme than the original collagen membrane due to the presence of silica, and the biodegradation rate of the samples was controllable through adjustment of the GPTMS content. Upon incubation with C2C12 skeletal myoblasts, both samples supported cell attachment, proliferation, and differentiation, suggesting good biocompatibility. However, a significant difference in cell morphology was observed. Cells on the flat membranes were randomly distributed, while those on the microgrooved samples were highly aligned and elongated, indicating that the microgrooved membranes exhibit much stronger cell contact guidance ability. The immunochemical assay showed that both flat and microgrooved samples supported the differentiation of C2C12 myoblasts to form multinucleated myotubes; however, the presence of the microgrooved surface topography significantly enhanced cell differentiation.

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“…This system presents a low rate of delivery, followed by a rather constant rate over the subsequent hours with a linear regression factor of 0.999. 58 Chart 2: Cumulative release profile of ATE over 10 h 58 SBA-15-collagen hybrid material was also synthesized byCao 59 it was used as a delivery system for ATE 60. The release kinetics of ATE/SBA-15 and ATE/SBA-15-collagen presented a lower delivery rate during the first 10 h for both of them.…”

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confidence: 99%

The role of SBA-15 in drug delivery

2015

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Controlled drug-delivery systems (DDSs) are one of the ideal methods for human health care in which the drug is released with a constant rate and its concentration in blood remains always steady. Pure and modified SBA-15, with a hexagonal structure and nano size pores has apiary-like structure, have attracted much attention as carriers in academic researches for delivery of natural and chemical drugs. In this review, preparation, characterization and application of various types of SBA-15 as drug delivers is investigated.

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SBA-15-collagen hybrid material for drug delivery applications

Cited by 41 publications

References 15 publications

Feasibility of silica-hybridized collagen hydrogels as three-dimensional cell matrices for hard tissue engineering

Feasibility of silica-hybridized collagen hydrogels as three-dimensional cell matrices for hard tissue engineering

Fabrication of novel collagen-silica hybrid membranes with tailored biodegradation and strong cell contact guidance ability

The role of SBA-15 in drug delivery

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