Saturated resins or stress of the resin

Sanclimens, Glòria; Crespo, Laia; Pons, Miquel; Giralt, Ernest; Alberício, Fernando; Royo, Míriam

doi:10.1016/s0040-4039(03)00109-6

Cited by 14 publications

(9 citation statements)

References 14 publications

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“…The resin suffered some ™aging∫ ± a term that describes the physical change in the resin after several ™aggressive∫ manipulations. In contrast, a previous paper has described ™stress∫ of the resin as the change in the resin after a few mild steps (amide formation) [11]. It is probable that the rigidity of the resin and the conformation adopted by the material does not allow a normal swelling process to occur.…”

Section: Resultsmentioning

confidence: 92%

A Combination of Different Spectroscopic Techniques to Monitor the “in situ” Solid‐phase Synthesis of Organic Molecules

Cironi¹,

Álvarez²,

Alberício³

2004

QSAR Comb. Sci.

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The efficacy, limitations and scope of different spectroscopic techniques to monitor solid-phase syntheses are discussed. The total solid-phase synthesis of a natural product derivative, 3,17-di-O-acetyllamellarin U, has been monitored by gel-phase NMR and HR-MAS NMR as appropriate. FT-IR and colorimetric tests also proved to be valuable tools for monitoring the progress of reactions. While the data obtained by FT-IR provided valuable information on some functional groups, the NMR data provided more specific structural information that allowed the progress of reactions to be monitored. After several reaction steps the ™aging∫ of the resin only allowed the product covalently anchored to the resin to be investigated using an HR-MAS probe, a situation that severely limited the depth of analysis available.

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Section: Resultsmentioning

confidence: 92%

A Combination of Different Spectroscopic Techniques to Monitor the “in situ” Solid‐phase Synthesis of Organic Molecules

Cironi¹,

Álvarez²,

Alberício³

2004

QSAR Comb. Sci.

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“…While preparing polyproline dendrons, Albericio and coworkers 36 also observed increased fragility of the beads, suggested that the bead breakdown resulted from the "saturation of the solid support," and proposed calling the phenomenon "stress of the bead." 54 An investigation of the properties of the PAMAMmodified silica by Tsubokawa et al 27 (and later by Reynhardt and Alper 28(c) and Kunitake et al 29(b) ) demonstrated a monotonic decrease in the average pore size, total pore volume, and surface area as a function of the generation. According to the suggested explanation, the mesopores of silica are gradually filled by the growing dendritic oligomer.…”

Section: Properties Of the Dendronized Supportsmentioning

confidence: 98%

“…In our experiments on polystyrene-polyether dendron supports, the lower crosslinking upon the complexation of monodentate phosphines to Co bimetallic and Pd monometallic sites was observed with both the naked eye and NMR (a narrowing of signals in gel-phase 31 P NMR). 54,63 …”

Section: Reduced Crosslinking Of the Polymer Upon Complexation When Ementioning

confidence: 99%

Dendrons and dendritic catalysts immobilized on solid support: Synthesis and dendritic effects in catalysis

Dahan

Portnoy

2004

J. Polym. Sci. A Polym. Chem.

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Dendrimers, the aesthetically beautiful macromolecules displaying a variety of potentially useful architecture-induced properties, are traditionally assembled in solution. However, since 1988, a number of dendritic structures have been assembled on insoluble organic and inorganic polymers, and thus dendronized supports have been formed. One of the major applications of these new materials is in the field of heterogeneous catalysis. Supported dendritic catalytic systems, bearing the catalytic units on the dendron periphery, have been examined in the last 5 years in such reactions as hydroformylation, Heck and other Pd-catalyzed COC bond formations, oxidation, and enantioselective addition to aldehydes. In the majority of these studies, substantial dendritic effects on the reactivity, selectivity, or recyclability of the catalysts were observed. Although a number of factors have been suggested as sources of the effects, it is most likely that the phenomenon has a multicomponent origin. Additional research, including a full determination of the effects and their causes, is likely to lead to markedly better heterogeneous catalytic systems.

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“…The evidence of the limits of resin bead capacity has been observed in the convergent solid-phase preparation of polyproline-based dendrimers [Fmoc-Pron-L-Amp(FmocPron) n -OH (n = 5, 14)] by Laia et al [21]. A high ratio of dendrimer-mass to bead-volume could generate an enormous amount of tension on the beads which produce stress and cause the beads to burst [22]. Therefore, special care is required in the solid-phase method for preparation of globular peptide dendrimers.…”

Section: The Synthesis Of Peptide Dendrimersmentioning

confidence: 99%

New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

Luo

She

et al. 2010

Sci. China Chem.

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Saturated resins or stress of the resin

Cited by 14 publications

References 14 publications

A Combination of Different Spectroscopic Techniques to Monitor the “in situ” Solid‐phase Synthesis of Organic Molecules

A Combination of Different Spectroscopic Techniques to Monitor the “in situ” Solid‐phase Synthesis of Organic Molecules

Dendrons and dendritic catalysts immobilized on solid support: Synthesis and dendritic effects in catalysis

New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

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