New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

Gu, Zhongwei; Luo, Kui; She, Wenchuan; Wu, Yao; He, Bin

doi:10.1007/s11426-010-0107-y

Cited by 48 publications

(35 citation statements)

References 165 publications

(191 reference statements)

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“…Dendrimers are particularly suitable candidates for the delivery of antitumor drugs due to their precisely controllable size, low polydispersity, and multiply modifiable surface functionality, with concomitant possibility to delivery drugs and optimize drug properties such as pharmacokinetics comparable to typical colloidal or macromolecular delivery systems . Peptide dendrimers have recently been explored as drug carriers with attractive characteristics of combining both dendrimer and peptide, resulting in some advantages, such as water‐solubility, biodegradability, biocompatibility, and immunocompatibility . Despite these promising features, challenges facing the in vivo antitumor application of peptide dendrimer drug delivery systems have remained since the reported dendrimers with small size were rapidly cleared from the circulation .…”

Section: Introductionmentioning

confidence: 99%

Peptide Dendrimer–Doxorubicin Conjugate‐Based Nanoparticles as an Enzyme‐Responsive Drug Delivery System for Cancer Therapy

Zhang

Pan

Luo

et al. 2014

Adv Healthcare Materials

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136

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Peptide dendrimers have shown promise as an attractive platform for drug delivery. In this study, mPEGylated peptide dendrimer-doxorubicin (dendrimer-DOX) conjugate-based nanoparticle is prepared and characterized as an enzyme-responsive drug delivery vehicle. The drug DOX is conjugated to the periphery of dendrimer via an enzyme-responsive tetra-peptide linker Gly-Phe-Leu-Gly (GFLG). The dendrimer-DOX conjugate can self-assemble into nanoparticle, which is confirmed by dynamic light scattering, scanning electron microscopy, and transmission electron microscopy studies. At equal dose, mPEGylated dendrimer-DOX conjugate-based nanoparticle results in significantly high antitumor activity, and induces apoptosis on the 4T1 breast tumor model due to the evidences from tumor growth curves, an immunohistochemical analysis, and a histological assessment. The in vivo toxicity evaluation demonstrates that nanoparticle substantially avoids DOX-related toxicities and presents good biosafety without obvious side effects to normal organs of both tumor-bearing and healthy mice as measured by body weight shift, blood routine test, and a histological analysis. Thus, the mPEGylated peptide dendrimer-DOX conjugate-based nanoparticle may be a potential nanoscale drug delivery vehicle for the breast cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Peptide Dendrimer–Doxorubicin Conjugate‐Based Nanoparticles as an Enzyme‐Responsive Drug Delivery System for Cancer Therapy

Zhang

Pan

Luo

et al. 2014

Adv Healthcare Materials

Self Cite

136

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“…Clinical studies benefit from newly developed biomaterials for therapy and diagnostics (Gu et al 2010) and also for medical instruments . The influence of polymer-based devices on cell surfaces is evaluated at the final product level as well as the polymers used in regenerative medicine (Scharnagl et al 2010).…”

Section: Bioengineeringmentioning

confidence: 99%

The age of biomedicine: current trends in traditional subjects

Berger¹

2011

JAB

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The earliest scientific journals on biomedicine began publication in the 50s and their authors addressed the application of biology to medicine. More recently, biochemistry and biomedical engineering questions have figured more prominently. This trend is discussed in a survey of the topics appearing in the Journal of Applied Biomedicine. Pharmacological and toxicological articles have been popular over the long term and the neurosciences, chronomedicine, molecular and cell biomedicine have also been very important. The role of computational biomedicine and nanomedicine has received increasing attention as has the part which applied biomedicine can play in the enhancement of the general economy.

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“…This compound also exhibited better tissue compatibility, reflected by no or less inflammatory response in the site of muscle injection. Recently, Gu's group [14] reviewed the development of peptide dendrimers with emphasis on their applications both in diagnostics and in therapy.…”

Section: Poly(amidoamine) Dendrimer Based Vectorsmentioning

confidence: 99%

Current progress of polymeric gene vectors

Zhang

Sun

Zhuo

et al. 2011

Sci. China Life Sci.

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After over 40 years of progress, gene therapy provides great opportunities for treating diseases from various genetic disorders, infections and cancers. The success of gene therapy largely depends on the availability of suitable gene vectors. As an attractive alternative to virus-based gene therapy, non-viral gene delivery system has been developed and investigated due to their merits including low immunogenecity, convenient operability, and large-scale manufacturability [1]. Because polycations can condense with DNA as a result of electrostatic interactions, form nanosize polyplexes, and protect DNA from degradation by DNase, cationic polymer becomes a major type of non-viral gene delivery vectors ( Figure 1) [2]. A wide range of polymeric vectors have been developed and investigated in the past decade, such as polyethylenimine (PEI)-based vectors, poly(L-lysine) (PLL)-based vectors, dendrimer-based vectors, polypeptide-based vectors, and chitosan-based vectors [3]. However, unlike viral vectors that have the ability to infect host cells and overcome cellular barriers through the course of evolution, nonviral gene vectors exhibit significantly reduced transfection efficiency as they are obstructed by various extra-and intracellular barriers, including serum proteins in blood stream, cell membrane, endosomal compartment and nuclear membrane [4].As a result, numerous studies have focused on designing polymer carriers that have smart molecular structure, present good biocompatibility, avoid both in vitro and in vivo barriers, and achieve successful delivery of genetic material [1]. To circumvent different systemic and cellular obstacles Figure 1 Three main strategies employed to package DNA [4].during gene delivery, proper functional groups were conjugated to polymeric vectors. The current modification of polymeric vectors has shown great improvements in enhancing intracellular gene transfer efficiency and attaining tumor targeted gene delivery [4]. For example, receptormediated cell uptake can quickly deliver ligand-targeted polyplexes into endosomes, membrane active compounds (lipids and peptides) can enhance the release of endocytosed materials. Moreover, nuclear localization signal peptides can enhance both the nuclear transport and expression of DNA. Here, current research progress regarding polymeric gene vectors that mainly published in Chinese magazines from 2010 was reviewed, and future trends for the polymer-based gene delivery systems would also be delineated.

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New-generation biomedical materials: Peptide dendrimers and their application in biomedicine

Cited by 48 publications

References 165 publications

Peptide Dendrimer–Doxorubicin Conjugate‐Based Nanoparticles as an Enzyme‐Responsive Drug Delivery System for Cancer Therapy

Peptide Dendrimer–Doxorubicin Conjugate‐Based Nanoparticles as an Enzyme‐Responsive Drug Delivery System for Cancer Therapy

The age of biomedicine: current trends in traditional subjects

Current progress of polymeric gene vectors

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