Saturated Fatty Acids as Possible Key Amplifiers of Psoriatic Dermatitis

Nakamizo, Satoshi; Honda, Tetsuya; Kabashima, Kenji

doi:10.1016/j.jid.2018.07.004

Cited by 9 publications

(11 citation statements)

References 8 publications

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“…7 The higher BMI and lower meat intake were independently associated with psoriasis, as analyzed by logistic regression. Both vitamin B 12 and vitamin D are rich in fish/shellfish, and thus the higher intake of these vitamins in the Japanese patients may be attributable to higher fish/shellfish intake. The present results indicate that Japanese psoriatic patients may prefer fish/shellfish and pulses to meat as side dishes, simply reflecting their taste.…”

Section: Discussionmentioning

confidence: 99%

“…Obesity is a pro‐inflammatory state, and visceral fat‐derived adipokines like leptin or visfatin induce the production of psoriasis‐promoting antimicrobial peptides, human β‐defensin‐2/3 or chemokines, CXCL8/10, CCL20 in epidermal keratinocytes, and link metabolic syndromes to psoriasis . Saturated fatty acid (SFA), rich in meat or butter, exacerbates psoriasis by promoting Th1/Th17 differentiation through activation of dendritic cells . The intake of dietary sulfur rich in red meat may generate hydrogen sulfide rendering the intestinal mucous layer penetrable to bacteria which reach the epithelium and activate Toll‐like receptors and the nuclear factor‐κB inflammatory pathway .…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] Saturated fatty acid (SFA), rich in meat or butter, exacerbates psoriasis by promoting Th1/Th17 differentiation through activation of dendritic cells. 12 The intake of dietary sulfur rich in red meat may generate hydrogen sulfide rendering the intestinal mucous layer penetrable to bacteria which reach the epithelium and activate Toll-like receptors and the nuclear factor-jB inflammatory pathway. 13 In contrast, n-3 polyunsaturated fatty acids (PUFA) like eicosapentaenoic acid and docosahexaenoic acid rich in fish are metabolized into resolvin E1 and D1, respectively, which resolve inflammation associated with psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…22 The effects of topical vitamin B 12 on psoriasis are also reported: it scavenges nitric oxides 23 and reactive oxygen species. 24 Several controlled and uncontrolled trials of systemic vitamin D or B 12 for psoriasis have been performed though the results are not conclusive. 19,21,25 The previous studies on dietary habits in psoriatic patients were mainly performed in Western countries.…”

Section: Introductionmentioning

confidence: 99%

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Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Yamashita

Morita

Ito

et al. 2019

The Journal of Dermatology

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Psoriasis is characterized by T‐helper 17 cell‐dominant abnormal immunity, and hyperproliferation and abnormal differentiation of epidermal keratinocytes. Some patients are associated with arthritis. Dietary habits can modulate the pathogenesis of psoriasis. Previous studies in Western countries showed higher body mass indices, higher intake of fat and lower intake of fish or vegetables in psoriatic patients compared with the reference groups. We evaluated dietary habits in adult Japanese psoriatic patients, using a validated brief‐type self‐administered dietary history questionnaire, and compared the results to those of age‐ and sex‐matched healthy controls. The results in psoriatic patients with arthritis were compared with those in the patients without. Japanese psoriatic patients showed higher body mass indices, higher intake of fish/shellfish, pulses, sugar/sweeteners, vitamin B12 and vitamin D, and lower intake of meat, compared with those of healthy controls. The logistic regression analysis showed that psoriasis was associated with high body mass index and low intake of meat. The intake of confection in patients with high Psoriasis Area and Severity Index was higher than that in those with low index. The intake of β‐carotene, vitamin A and green/yellow vegetables in psoriatic patients with arthritis were higher than those in the patients without. The dietary habits in Japanese psoriatic patients are rather different from those in Western patients. This is the first study showing the differences in dietary habits between psoriatic patients with arthritis and those without. Further studies should elucidate the relationships of these results with skin and joint lesions in psoriatic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Yamashita

Morita

Ito

et al. 2019

The Journal of Dermatology

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“…The high-fat diet rich in SFAs exacerbates the IMQ-induced psoriasiform dermatitis in mice [ 13 , 14 ]; SFAs activate nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 (NLRP3) inflammasome which generates active IL-1β and IL-18 in CD11c+ macrophages [ 14 , 15 , 16 ]. The increased IL-1β promotes the expression of CCL20 in the epidermis, leading to the accumulation of Th17 cells and γδT17 cells into the skin lesions [ 13 , 14 , 17 ]. SFAs induce the expression of epidermal-type fatty acid-binding protein (E-FABP), an intracellular chaperone coordinating lipid trafficking, and the E-FABP further couples lipid droplet formation and NLRP3-apoptosis-associated speck-like protein containing a caspase recruiting domain (ASC)-Caspase-1 inflammasome activation in CD11c+ macrophages [ 18 ].…”

Section: The Nutrients or Food Related To Psoriasismentioning

confidence: 99%

Nutrition and Psoriasis

Kanda

Hoashi

Saeki

2020

IJMS

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Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal differentiation of epidermal keratinocytes. Psoriasis patients are frequently associated with obesity, diabetes, dyslipidemia, cardiovascular diseases, or inflammatory bowel diseases. Psoriasis patients often show unbalanced dietary habits such as higher intake of fat and lower intake of fish or dietary fibers, compared to controls. Such dietary habits might be related to the incidence and severity of psoriasis. Nutrition influences the development and progress of psoriasis and its comorbidities. Saturated fatty acids, simple sugars, red meat, or alcohol exacerbate psoriasis via the activation of nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 inflammasome, tumor necrosis factor-α/interleukin-23/interleukin-17 pathway, reactive oxygen species, prostanoids/leukotrienes, gut dysbiosis or suppression of regulatory T cells, while n-3 polyunsaturated fatty acids, vitamin D, vitamin B12, short chain fatty acids, selenium, genistein, dietary fibers or probiotics ameliorate psoriasis via the suppression of inflammatory pathways above or induction of regulatory T cells. Psoriasis patients are associated with dysbiosis of gut microbiota and the deficiency of vitamin D or selenium. We herein present the update information regarding the stimulatory or regulatory effects of nutrients or food on psoriasis and the possible alleviation of psoriasis by nutritional strategies.

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Production of polyunsaturated fatty acids in pork backfat fermented by Mucor circinelloides

Shi,

Zhang,

Lin

et al. 2024

Appl Microbiol Biotechnol

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Pork backfat (PB) contains excessive saturated fatty acids (SFAs), but lacks polyunsaturated fatty acids (PUFAs). Excessive SFAs can be used as a substrate for the growth of certain microorganisms that convert them into PUFAs and monounsaturated fatty acids (MUFAs), and the added value of PB can be enhanced. In this study, Mucor circinelloides CBS 277.49 and Lactiplantacillus plantarum CGMCC 24189 were co-cultured for conversion of PB into fermented pork backfat (FPB) with high level of PUFAs. Our results showed that the content of γ-linolenic acid (GLA) and linoleic acid (LA) in the surface of FPB reached 9.04 ± 0.14 mg/g and 107.31 ± 5.16 mg/g for 7-day fermentation, respectively. To convert the internal SFAs of PB, ultrasound combined with papain was used to promote the penetrative growth of M. circinelloides into the internal PB, and the GLA level in the third layer of fat reached 2.58 ± 0.31 mg/g FPB. The internal growth of M. circinelloides in PB was promoted by adjusting the oxygen rate and ventilation rate through the wind velocity sensor. When the oxygen rate is 2 m/s and the ventilation rate is 18 m3/h, the GLA level in the third layer of fat reached 4.13 ± 1.01 mg/g FPB. To further improve the level of PUFAs in PB, FPB was produced by M. circinelloides at 18 °C. The GLA content on the surface of FPB reached 15.73 ± 1.13 mg/g FPB, and the GLA yield in the second and third layers of fat reached 8.68 ± 1.77 mg/g FPB and 6.13 ± 1.28 mg/g FPB, the LA yield in the second and third layers of fat reached 105.45 ± 5.01 mg/g FPB and 98.46 ± 4.14 mg/g FPB, respectively. These results suggested that excessive SFAs in PB can be converted into PUFAs and provided a new technique for improving PUFAs in FPB. Key points • This article achieved the conversion of PUFAs in pork backfat by Mucor circinelloides CBS 277.49 and Lactiplantacillus plantarum CGMCC 24189. • This article solved the internal growth of M. circinelloides CBS277.49 in pork backfat by ultrasound combined with papain. • This article proposed an innovative of promoting the internal growth of M. circinelloides and increasing the PUFAs production by oxygen ventilation in pork backfat.

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Saturated Fatty Acids as Possible Key Amplifiers of Psoriatic Dermatitis

Cited by 9 publications

References 8 publications

Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Dietary habits in Japanese patients with psoriasis and psoriatic arthritis: Low intake of meat in psoriasis and high intake of vitamin A in psoriatic arthritis

Nutrition and Psoriasis

Production of polyunsaturated fatty acids in pork backfat fermented by Mucor circinelloides

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