Sativa seeds against Schistosoma mansoni different stages

A review on therapeutic potential of Nigella sativa: A miracle herb

“…N. sativa seeds also induced an oxidative stress against adult worms which indicated by a decrease in the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the anti-schistosomal potency of the N. sativa seed [35] . The antioxidant and anti-schistosomal activities of the garlic extract (AGE) and NSO on normal and Schistosoma mansoni-infected mice was investigated.…”

In vivo and In vitro of Arctiin Schistosomicidal Activity

“…The spread of schistosomiasis endemic areas and increasing infection rate [1][2][3][4][5][6][7][8][9] support the need of new drug discovery and development [5][6][7][8][9]. Research of natural products has provided remarkable new drugs or drug leads to combat several diseases [14][15][16][17][18].…”

“…However, PZQ has only a limited effect on already developed liver and spleen lesions and there is a considerable concern about the development of PZQ resistance [8,9]. Such facts have encouraged the scientific community to develop novel and inexpensive drugs against schistosomiasis [7][8][9].…”

“…However, PZQ has only a limited effect on already developed liver and spleen lesions and there is a considerable concern about the development of PZQ resistance [8,9]. Such facts have encouraged the scientific community to develop novel and inexpensive drugs against schistosomiasis [7][8][9]. In this regard, a number of studies have been developed with natural products from medicinal plants to identify a leading compound that can be used for the treatment of schistosomiasis [10][11][12].…”

The Use of Brazilian Medicinal Plants to Combat Schistosoma mansoni

“…As a result, research with medicinal plants constitutes a very viable alternative. In this scenario, several studies and researches on natural bioactive products extracted from plants and used against schistosomiasis have been carried out in the search for a new medicine that can replace praziquantel or complement it (Xiao & Catto, 1989, Molgaard et al, 2001, Mahmoud et al, 2002, Mohamed et al, 2005, Shaohong et al, 2005, Penido et al, 2008, Moraes et al, 2010. Taking into account the great variety of plants that haven't yet been therapeutically studied to combat S. mansoni schistosomiasis, in recent years our research group started a multidisciplinary project to perform in vitro screening of extracts from native and exotic plants commonly cultivated in Brazil.…”