Satiation and Masticatory Function Modulated by Brain Histamine in Rats

Fujise, Takako; Yoshimatsu, Hironobu; Kurokawa, Mamoru; Oohara, Akihiko; Kang, Masahiro; Nakata, M.; Sakata, Toshiie

doi:10.3181/00379727-217-44227

Cited by 56 publications

(25 citation statements)

References 12 publications

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“…Each of these attributes has been associated with weaker effects on appetite and dietary compensation. [52][53][54][55][56][57][58][59] The absolute and relative importance of these properties, and others, has not been established, but warrant exploration. In summary, the present trial supports an independent effect of food rheology on energy intake.…”

Section: Discussionmentioning

confidence: 99%

Effects of food form on appetite and energy intake in lean and obese young adults

et al. 2007

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Objective: To investigate the independent effect of food form on appetite and energy intake in lean and obese adults using high carbohydrate, fat or protein food stimuli. Design: Crossover dietary challenge with matched beverage and solid food forms: high carbohydrate (watermelon and watermelon juice); high protein (cheese and milk); high fat (coconut meat and coconut milk). Results: Regardless of the predominant energy source, the beverage food form elicited a weaker compensatory dietary response than the matched solid food form. Thus, total daily energy intake was significantly higher by 12.4, 19 and 15% on days the beverage forms of the high-carbohydrate, -fat and -protein foods were ingested, respectively. This was due more to a weak effect on satiety than satiation. The obese participants had higher energy intake at the lunch, including the beverage highprotein load, but overall differences between lean and obese participants were small and not systematic. Conclusion: Food rheology exerts an independent effect on energy intake. Dietary compensation for beverages is weaker than for solid food forms of comparable nutrient content. Thus, they pose a greater risk for promoting positive energy balance.

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Section: Discussionmentioning

confidence: 99%

Effects of food form on appetite and energy intake in lean and obese young adults

et al. 2007

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“…Foods rich in dietary fiber might promote satiation through prolonged mastication. Experimental animal studies showed that mastication is important for energy metabolism [33,34]. Mastication leads to an activation of hypothalamic histamine neurons.…”

Section: Dietary Fibermentioning

confidence: 99%

“…H 1 receptors located in the satiety centers of the ventromedial hypothalamus and the paraventricular nucleus are suppressed through histamine neuron activation. This affects eating volume and eating speed [34]. Furthermore, histamine neuron activation accelerates lipolysis, particularly in visceral adipocyte, and increases uncoupling protein (UCP) gene expression in mice [35].…”

Section: Dietary Fibermentioning

confidence: 99%

Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes

Schröder

2007

The Journal of Nutritional Biochemistry

284

217

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“…[1][2][3][4] The very central function of neural histamine in regulation of food intake 1,[5][6][7] is further underlined by the fact that leptin, 8,9 amylin 10,11 and bombesin 12 have been suggested to exert their anorectic effects through histaminergic circuits. In accordance herewith, histamineric neurons project into hypothalamic centres known to participate in food intake regulation: the paraventricular nucleus (PVN) and ventromedial hypothalamus (VMH), where the anorectic effect is thought to be mediated by postsynaptic histamine H 1 receptors.…”

Section: Introductionmentioning

confidence: 99%

Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight

Malmlöf¹,

Zaragoza²,

Golozoubova³

et al. 2005

Int J Obes

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OBJECTIVE: This study was conducted to elucidate whether antagonistic targeting of the histamine H 3 receptor increases hypothalamic histamine levels, in parallel with decreases in food intake and body weight. METHODS:The competitive antagonist potency of a recently synthesized histamine H 3 receptor antagonist, NNC 38-1049, was studied in intact HEK293 cells expressing human or rat histamine H 3 receptor, in which NNC 38-1049 was allowed to antagonize the effect of the H 3 receptor agonist R-a-methylhistamine on isoprenaline-induced accumulation of cAMP. The affinity of NNC 38-1049 for a number of variants of the histamine receptor was also determined. Following single dosing of normal rats with NNC 38-1049, hypothalamic histamine levels were assessed by means of microdialysis. Plasma and brain levels of NNC 38-1049 and acute effects on food intake and energy expenditure were followed after oral doses of 3-60 mg/kg. Potential side effects were examined with rat models of behaviour satiety sequence (BSS), pica behaviour and conditioned taste aversion (CTA). Intakes of food and water together with body weight were recorded for 15 days during daily dosing of dietary obese rats. RESULTS: NNC 38-1049 was found to be a highly specific and competitive antagonist towards both human and rat histamine H 3 receptors, and measurable amounts of NNC 38-1049 were found in the plasma of rats following single oral doses of 3-60 mg/kg and in the brain after 15-60 mg/kg. Following single intraperitoneal injections of NNC 38-1049 (20 mg/kg), significant increases in extracellular histamine concentrations were observed. The same dose did not change BSS or pica behaviour acutely, nor did it induce CTA following repeated administration for 7 days. Reductions in food intake were seen very soon after administration, and occurred in a dose-dependent fashion. Energy expenditure was unchanged, but the respiratory quotient (RQ) tended to decrease at higher doses, indicating an increase in lipid oxidation. Twice daily administration of 20 mg/kg of NNC 38-1049 in old and dietary obese rats resulted in sustained reduction of food intake throughout a 2-week study, and was associated with a highly significant (Po0.01) decrease in body weight compared with controls (À18.473.4 vs þ 0.472.7 g). The same dose of NNC 38-1049 produced an acute decrease of water intake, but 24 h intakes were not significantly changed. CONCLUSIONS: The results of this study strongly support the idea that an increase in the hypothalamic concentration of histamine produces a specific reduction of food intake and that this effect can be translated into a decrease in body weight.

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Satiation and Masticatory Function Modulated by Brain Histamine in Rats

Cited by 56 publications

References 12 publications

Effects of food form on appetite and energy intake in lean and obese young adults

Effects of food form on appetite and energy intake in lean and obese young adults

Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes

Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight

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