Satellite cells and skeletal muscle regeneration

Church, John; Noronha, Reynold F.X.; Allbrook, David

doi:10.1002/bjs.1800530720

Cited by 85 publications

(28 citation statements)

References 5 publications

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“…Einerseits werden die Satellitenzellen als Regenerations zellen diskutiert, anderseits denkt man an eine Entdifferenzierung der Myonuklei zu Myo blasten, die dann wieder teilungsfähig werden und somit gewissermassen embryonalen Cha rakter annchmen [Carlson, 1973]. Diese Frage ist jedoch noch nicht eindeutig geklärt [All brook, 1962: Walker, 1963: Lee, 1965: Muh et al, 1965: Church, 1966: Shafiq et al, 1967Hess und Rosner, 1970;Terävainen, 1970;Allbrook et al, 1970] [ 1963,1964] und Thompson [ 1971 a,b], denen zufolge die vorausgehende Denervation das Angehen eines freien Muskeltransplan tates erheblich verbessert. Thompson [1971a, b] …”

Section: Materials Und Methodseunclassified

Lichtmikroskopische und elektronenoptische Untersuchungen morphologischer Veränderungen von Muskelfasern bei freier autologer Muskeltransplantation

Lischka¹,

Holle²,

Freilinger³

1977

Cells Tissues Organs

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The extensor digitorum longus muscle of the rat was denervated and transplanted onto the vastus lateralis muscle of the same limb 1 or 2 weeks after denervation. The morphological changes appearing after transplantation were examined by light and electron microscopy. Only three to four superficial layers of muscle fibres remained unchanged after transplantation. The other parts of the transplanted muscle degenerated nearly entirely during the first 10 days. The myofibrils were removed by macrophages, thus within the tubes of basal lamina no contractile material could be observed. In a second period, regeneration of myofilaments took place. 6 weeks after transplantation, newly formed muscle could be observed, capable of normal function. The diameter of the fibres, however, was smaller and the connective tissue between the fibres markedly increased as compared to the normal muscle of the other side. The importance of the findings for muscle transplantation, especially the relationship between satellite cells and myoblasts, is discussed.

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Section: Materials Und Methodseunclassified

Lichtmikroskopische und elektronenoptische Untersuchungen morphologischer Veränderungen von Muskelfasern bei freier autologer Muskeltransplantation

Lischka¹,

Holle²,

Freilinger³

1977

Cells Tissues Organs

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“…Studies throughout the 1960s indicated that satellite cells were the likely myogenic precursors for muscle regeneration (e.g. Church et al, 1966;Shafiq and Gorycki, 1965), and they were seen to undergo cell division in regenerating muscle (Reznik, 1969). It was not until the culture of isolated myofibres, however, that it was unambiguously demonstrated that satellite cells generate progeny that become myoblasts (Bischoff, 1975;Konigsberg et al, 1975).…”

Section: A Cell On the Edgementioning

confidence: 99%

“…Satellite cells not only generate myoblasts, but also re-appear in their niche as myotubes reform (Church et al, 1966). That this was selfrenewal was implied from lineage tracing in growing muscle, where it was observed that a satellite cell division could lead to one progeny that differentiated into a myonucleus, while the other remained a satellite cell (Moss and Leblond, 1971).…”

Section: Satellite Cells Are Muscle-resident Myogenic Stem Cellsmentioning

confidence: 99%

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

2012

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SummaryFollowing their discovery in 1961, it was speculated that satellite cells were dormant myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established. Subsequently, it was demonstrated that, when grafted, satellite cells could also self-renew, conferring on them the coveted status of 'stem cell'. The emergence of other cell types with myogenic potential, however, questioned the precise role of satellite cells. Here, we review recent recombination-based studies that have furthered our understanding of satellite cell biology. The clear consensus is that skeletal muscle does not regenerate without satellite cells, confirming their pivotal and non-redundant role.

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“…The dediffertntiated cellsnoted bySpeidel (1938) in skeletal muscle and by me in cardiac muscle show the similarity of their origin and transformation into muscle fibres of respective orders. The dedifferentiated cells that Speidel found in skeletal muscle are similar to what have more recently been termed 'satellite cells' by Mauro (1961) and Church, Noronha, and Allbrook (1966) with a remarkable potential for regeneration of skeletal muscle in case of injury.…”

Section: Discussionmentioning

confidence: 84%

Myocardial lysis in acute rheumatic fever followed by regeneration of cardiac muscle and origin of Aschoff bodies.

McDonald¹

1975

J Clin Pathol

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In acute rheumatic heart disease, lysis of cardiac muscle fibres with or without retention of sarcolemma is found to be the most damaging feature in many cases. In deeper myocardium the cellular lysis often forms anastomosing clefts or sinus-like spaces between surviving muscle bundles and in the outer portion of myocardium cellular lysis may leave the sarcolemma more or less intact. From lysing cardiac muscle fibres there arise dedifferentiated cells with remarkable potentiality for regeneration. For the origin of these dedifferentiated cells, which are often indistinguishable from lymphocytes, no mitosis is seen in cardiac muscle cells. The successive stages of development of muscle cell from these dedifferentiated cells within the remaining or newly formed sarcolemma have been observed in this study. This study infers that the increased number of fibrous septa, when seen, denotes the tracks of previous muscle degeneration and subsequent replacement of it with incomplete muscle regeneration and fibrous tissue formation. In an area of muscle lysis the origin of Aschoff bodies from these dedifferentiated cells has been followed. Ashoff bodies arising in this was behave as an abortive and atypical growth of muscle fibres in a nodular fashion specific to rheumatic fever.

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Satellite cells and skeletal muscle regeneration

Cited by 85 publications

References 5 publications

Lichtmikroskopische und elektronenoptische Untersuchungen morphologischer Veränderungen von Muskelfasern bei freier autologer Muskeltransplantation

Lichtmikroskopische und elektronenoptische Untersuchungen morphologischer Veränderungen von Muskelfasern bei freier autologer Muskeltransplantation

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

Myocardial lysis in acute rheumatic fever followed by regeneration of cardiac muscle and origin of Aschoff bodies.

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