SAT0567 Impact of chikungunya fever on functional status and quality of life – a prospective cohort study of brazilian patients

Abstract

BackgroundAn epidemic of Chikungunya Fever (CF) spread throughout South America in 2014. The acute manifestation of CF typically consists of febrile arthritis. The burden of the chronic articular manifestations remains a public health issue affecting activities of daily life. There is a very important impact on quality of life in patients affected by CF, even at chronic phase. The long-term functional status may also be affected by CF.ObjectivesTo evaluate longitudinally the disability, Health Related Quality of Life (HRQOL) and functional status of patients with CF and analyze the clinical and epidemiological factors associated with different outcomes.MethodsPatients with clinical and demographic diagnosis of CF and persistent articular symptoms were evaluated in a cohort study between May 2016 and December 2016. HRQOL was rated by Short-Form 12 (SF-12) and the functional status was checked through Health Assessment Questionnaire (HAQ) and the Global Functional Status (GFS). Data were divided per weeks after disease onset and were analysed (Spearmans's correlation coefficient and Mann-Whitney test).ResultsSixty-five patients (58 females), mean age of 51.3 (±13.3) were assessed. As expected, a significant correlation between pain related scores and Physical Health Composite Scale Score (PCS), HAQ and GFS was found (p<0.05)). Edema and morning stiffness correlated with PCS, HAQ and GFS status from 4 to 20 weeks after disease onset (p<0.05). There was improvement in scores of all instruments used from 4–8 weeks of disease to 12–16 weeks of disease (table 1). The worst indices of PCS, Mental Health Composite Scale Score (MCS) and GFS were scored in the first month, mean scores of 30.07±5.77, 38.13±8.54 and 3.15±1.07 respectively. Higher HAQ values were demonstrated between 4 and 8 weeks after disease onset (mean score 1.87±0.82).HRQOL and Functional Status in patients with CF4–8 weeks of disease12–16 weeks of diseaseP value (mean score)(mean score) PCS30.12±8.2135.86±11.110.0487MCS40.95±12.2347.02±12.090.0326HAQ1.87±0.821.36±0.860.0228Global Functional Status3.03±0.982.53±0.950.0438ConclusionsWe demonstrated the impact of CF on HRQOL and Functional Status of patients. The SF-12 Health Survey, HAQ and GFS are influenced mostly by patients pain and worsening of this status are more prominent in the first 8 weeks of disease. Further clinical studies of the impact of CF on quality of life and functional studies are neededReferences Soumahoro MK, Gérardin P, Boëlle PY et al. Impact of Chikungunya virus infection on health status and quality of life: a retrospective cohort study. PLoS One. 2009 Nov 11;4(11):e7800.Rahim AA, Thekkekara RJ, Bina T et al. Disability with Persistent Pain Following an Epidemic of Chikungunya in Rural South India. J Rheumatol. 2016 Feb;43(2):440–4.Couturier E, Guillemin F, Mura M et al. Impaired quality of life after chikungunya virus infection: a 2-year follow-up study. Rheumatology (Oxford). 2012 Jul;51(7):1315–22. Disclosure of InterestNone declared