“…Indeed, as an improvement in HRCT findings has been observed in only 5% of patients with GGO and nonfibrotic interstitial opacities, it is reasonable to presume that GGO may represent fibrosis in many SSc cases [ 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. Over time, apart from inflammation, fibrosis is the main histologic finding, even GGO, which represents fine reticulation and is rarely reversed but rather replaced later by overt fibrotic findings, such as reticulation or honeycombing/traction bronchiectasis and/or bronchiolectasis [ 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. However, HRTC does have some drawbacks, including the resolution limitations of CT, e.g., anatomical structures are disclosed by variations in density measured in spatial units ‘voxels’), X-ray exposure of patients and a lack of longitudinal studies on CT changes in SSc patients with and without treatment [ 48 , 49 , 50 , 51 , 52 , 53 , 54 ].…”