SARS-CoV-2 Omicron Variant Exponential Transmission &amp;amp; Mitigation Dynamics: Translational Immuno-Epidemiologic Perspective

Holmes, Laurens; Dabney, Kirk W.; Ogundele, Benjamin; Chavan, Prachi; Adhikari, Ramesh; Halloran, Daniel; Ogungbade, Gbadebo; Mellekate, Vishwas S; Nelson, C. Mindy; Williams, Janille; Deepika, Keerti

doi:10.2139/ssrn.3993979

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…As a result, a substantial number of breakthrough infections in vaccinated people have been documented around the world [353,354]. The poor cross reactivity of antibodies in suppressing Omicron replication, as well as replication in the URT, results in infection and transmission in vaccinated individuals [355].…”

Section: Vaccine Effectiveness and Vaccine Breakthroughmentioning

confidence: 99%

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

Hoteit

Yassine

2022

Vaccines

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide. Several vaccines have been produced and tested over the last two years. The SARS-CoV-2 virus, on the other hand, has mutated over time, resulting in genetic variation in the population of circulating variants during the COVID-19 pandemic. It has also shown immune-evading characteristics, suggesting that vaccinations against these variants could be potentially ineffective. The purpose of this review article is to investigate the key variants of concern (VOCs) and mutations of the virus driving the current pandemic, as well as to explore the transmission rates of SARS-CoV-2 VOCs in relation to epidemiological factors and to compare the virus’s transmission rate to that of prior coronaviruses. We examined and provided key information on SARS-CoV-2 VOCs in this study, including their transmissibility, infectivity rate, disease severity, affinity for angiotensin-converting enzyme 2 (ACE2) receptors, viral load, reproduction number, vaccination effectiveness, and vaccine breakthrough.

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Section: Vaccine Effectiveness and Vaccine Breakthroughmentioning

confidence: 99%

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

Hoteit

Yassine

2022

Vaccines

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COVID-19 Infection and Guillain-Barre Syndrome: A Case Series

Carpenter¹,

Iqbal²,

Singh³

et al. 2022

Cureus

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The coronavirus disease 2019 (COVID-19) pandemic brought about an unprecedented time. Multiple systemic complications have been recognized with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as it can do much more than affect the respiratory system. One of the intriguing neurological complications is Guillain-Barre syndrome (GBS). We reviewed three cases in which patients presented with GBS following COVID-19 infection. All three cases had positive lumbar puncture results with albuminocytological dissociation. Each patient was treated with plasmapheresis and improved clinically. Although an exact causal relationship between COVID-19 and GBS cannot be drawn from this case series alone, it signifies the importance of this complication. It warrants further studies to establish the causal relationship. One should have a high suspicion for acute inflammatory demyelinating polyneuropathy (AIDP) in patients presenting with acute onset of ascending weakness following COVID-19 infection.

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SARS-CoV-2 Omicron Variant Exponential Transmission & Mitigation Dynamics: Translational Immuno-Epidemiologic Perspective

Cited by 2 publications

References 4 publications

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences

COVID-19 Infection and Guillain-Barre Syndrome: A Case Series

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