SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

Menuchin-Lasowski, Yotam; Schreiber, André; Lecanda, Aarón; Mecate-Zambrano, Angeles; Brunotte, Linda; Psathaki, Olympia E.; Ludwig, Stephan; Rauen, Thomas; Schoeler, Hans Robert

doi:10.1101/2021.10.09.463766

Cited by 3 publications

(4 citation statements)

References 61 publications

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“…In the eyes, corneal small nerve fibre loss and increased dendritic cell density have been found in long COVID 87,88 , as well as significantly altered pupillary light responses 89 and impaired retinal microcirculation 90 . SARS-CoV-2 can infect and replicate in retinal 59 and brain 91 organoids. Other manifestations of long COVID include retinal haemorrhages, cotton wool spots and retinal vein occlusion 92 .…”

Section: Neurological and Cognitive Systemsmentioning

confidence: 99%

“…Several reports have pointed towards possible viral persistence as a driver of long COVID symptoms; viral proteins and/or RNA has been found in the reproductive system, cardiovascular system, brain, muscles, eyes, lymph nodes, appendix, breast tissue, hepatic tissue, lung tissue, plasma, stool and urine [55][56][57][58][59][60] . In one study, circulating SARS-CoV-2 spike antigen was found in 60% of a cohort of 37 patients with long COVID up to 12 months after diagnosis compared with 0% of 26 SARS-CoV-2-infected individuals, likely implying a reservoir of active virus or components of the virus 16 .…”

Section: Introductionmentioning

confidence: 99%

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Long COVID: major findings, mechanisms and recommendations

Davis¹,

McCorkell²,

et al. 2023

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Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field. In this Review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses. Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process.

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Section: Neurological and Cognitive Systemsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long COVID: major findings, mechanisms and recommendations

Davis¹,

McCorkell²,

et al. 2023

View full text Add to dashboard Cite

show abstract

“…These researchers demonstrated the dependency of SARS-CoV-2 on ACE-2 for infecting retinal cells. Taking everything into account, the involvement of the retina in COVID-19 can be considered a safety alarm for monitoring retinal disorders following SARS-CoV-2 infection [103].…”

Section: Retinal Organoidsmentioning

confidence: 99%

Insights into organoid-based modeling of COVID-19 pathology

Boroojerdi

Jabry

Mirarefin

et al. 2023

Virol J

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Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.

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“…A study by Lasowski et al showed that SARS-CoV-2 infected human stem cell-derived retinal organoids increased the production of several inflammatory genes associated with acute COVID-19 and retinal degeneration, including IL-33, CXCL2, and CXCL10. This study further showed that the inhibition of ACE2 activity with antibody significantly reduced SARS-CoV-2 infection of retinal organoids, indicating that SARS-CoV-2 infects retinal cells in an ACE2dependent manner [147].…”

Section: Sars-cov-2 Infection Exacerbates Diabetes-induced Eye Diseasesmentioning

confidence: 56%

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Roy¹,

Runa²

2022

Preprint

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Since the discovery of the Coronavirus disease 2019 (COVID-19) outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ dysfunction, while the co-existence of these two culprits can accelerate the pathophysiology and magnify the severity of the diseases. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases of multiple organs, including the lungs, heart, kidney, brain, eyes, gastrointestinal system, and bones, and subsequent manifestation of multi-system organ failure.

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SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

Cited by 3 publications

References 61 publications

Long COVID: major findings, mechanisms and recommendations

Long COVID: major findings, mechanisms and recommendations

Insights into organoid-based modeling of COVID-19 pathology

SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

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