SARS-CoV-2 infection and Diabetes: Pathophysiological Mechanism of Multi-System Organ Failure

Abstract

Since the discovery of the Coronavirus disease 2019 (COVID-19) outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ dysfunction, while the co-existence of these two culprits can accelerate the pathophysiology and magnify the severity of the diseases. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases of multiple organs, including the lungs, heart, kidney, brain, eyes, gastrointestinal system, and bones, and subsequent manifestation of multi-system organ failure.

Covid-19 Pandemijos Poveikis Lėtinėmis Ligomis Sergantiems Pacientams

“…COVID-19 ligos pasekmėmis gali būti laikomi ir kortikosteroidų sukelti naujai užregistruoti CD atvejai, ir jau sergančių CD pacientų ligos paūmėjimas, nes pastarieji gali susidurti su dar didesniais sunkumais, reguliuojant gliukozės kiekį kraujyje bei SARS-CoV-2 viruso sukeltais įvairių organų sistemų pažeidimais. CD ir SARS-CoV-2 sąveika sustiprina šių ligų sunkumą, didina gretutinių ligų ir mirtingumo riziką [27].…”