SARS-CoV-2 infection is associated with an increased risk of idiopathic acute pancreatitis but not pancreatic exocrine insufficiency or diabetes: long-term results of the COVIDPAN study

Nayar, Manu; Varghese, Chris; Kanwar, Aditya; Siriwardena, Ajith K.; Haque, Ali; Awan, Altaf; Balakrishnan, Anita; Rawashdeh, Arab; Ivanov, B.; Parmar, Chetan; Halloran, Christopher; Caruana, Clifford; Borg, Cynthia-Michelle; Gomez, Dhanny; Damaskos, Dimitrios; Karavias, Dimitrios; Finch, Guy; Ebied, Husam; Pine, James; Skipworth, James; Milburn, James; Latif, Javed; Apollos, Jeyakumar; Kafsi, Jihène El; Windsor, John A.; Roberts, Keith; Wang, Kelvin C. P.; Ravi, K; Coats, Maria; Hollyman, Marianne; Phillips, Mary; Okocha, M; Wilson, Michael; Ameer, Nadeem A; Kumar, Nagappan; Shah, Nehal; Lapolla, Pierfrancesco; Magee, C; Al-Sarireh, Bilal; Lunevičius, Raimundas; Benhmida, Rami; Singhal, Rishi; Balachandra, Srinivasan; Atıcı, Semra Demirli; Jaunoo, Shameen; Dwerryhouse, S; Boyce, Tamsin; Charalampakis, Vasileios; Kanakala, Venkat; Abbas, Zaigham; Tewari, Nilanjana; Pandanaboyana, Sanjay

doi:10.1136/gutjnl-2021-326218

Cited by 12 publications

(12 citation statements)

References 10 publications

(16 reference statements)

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“…Of the two studies that report no association, one examined any new diabetes diagnosis in 1.85 million people aged <35 years (i.e., Type 1 diabetes) in Scotland (Hazard Ratio: 0.86, 95%CI: 0.62-1.21) [30] and the other examined new-onset diabetes 12-months after hospitalization with acute pancreatitis (and with vs. without COVID-19 infection) (OR: 0.61 (0.13-2.96). [31] …”

Section: Resultsmentioning

confidence: 99%

The bidirectional association between diabetes and long-COVID-19 – A systematic review

Harding

Oviedo

Ali

et al. 2023

Diabetes Research and Clinical Practice

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Section: Resultsmentioning

confidence: 99%

The bidirectional association between diabetes and long-COVID-19 – A systematic review

Harding

Oviedo

Ali

et al. 2023

Diabetes Research and Clinical Practice

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“…We recently published the COVIDPAN study1 and follow-up data2 in Gut , which explored the association between concomitant SARS-CoV-2 infection and acute pancreatitis (AP) 1 2. We would like to further report the impact of SARS-CoV-2 pandemic on aetiology and management of patients presenting with AP, particularly those with gallstone pancreatitis (GSP) in a cohort of patients who did not have SARS-CoV-2 infection.…”

mentioning

confidence: 99%

SARS-CoV-2 pandemic has impacted on patterns of aetiology for acute pancreatitis and management of gallstone pancreatitis in the UK

Varghese

Nayar

Pandanaboyana

2022

Gut

Self Cite

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“…COVID-19-AP has been associated with a significant increment (2.5-fold) in the incidence of idiopathic pancreatitis compared to patients without COVID-19. This observation suggests that the SARS-CoV-2 virus may cause AP[ 10 , 11 ]. A study conducted in Serbia described that 15%-19% of patients with SARS-CoV-2 infections developed gastrointestinal symptoms[ 12 , 13 ].…”

Section: Etiologies Of Non-covid-19 Related and Covid-19-related Apmentioning

confidence: 99%

“…However, a United Kindom study reported that SARS-CoV-2 infection increases the risk of idiopathic AP, but not long-term diabetes. Thus, further laboratory studies that prove the SARS-CoV-2 virus replicates in human pancreatic cells and causes subsequent cell injury are warranted to establish SARS-CoV-2 as an etiology of AP[ 10 , 15 ].…”

Section: Etiologies Of Non-covid-19 Related and Covid-19-related Apmentioning

confidence: 99%

“…Patients who recover from COVID-19 exhibit sustained glycemic abnormalities for 2 mo. Moreover, some patients developed diabetes mellitus during follow-up; both of these patients had severe necrotic AP, which is likely to be the cause of DM rather than SARS-CoV-2-induced damage[ 10 ]. The association between the lipase/Lymphocyte ratio and predicting mortality was investigated in patients diagnosed with COVID-19 and AP[ 33 ].…”

Section: Outcome and Prognosis Of Covid-19-related Apmentioning

confidence: 99%

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Surgical intervention for acute pancreatitis in the COVID-19 era

Su¹,

Chen²

2022

World J Clin Cases

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Approximately 15%-19% of patients with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections develop gastrointestinal symptoms. Acute pancreatitis (AP) has been reported in 0.1% of patients with coronavirus disease 2019 (COVID-19). Biliary AP was most common (78.4%) before the COVID-19 pandemic; idiopathic AP is most common in patients with COVID-19 (up to 57.1%). The number of emergency department presentations decreased by 23.3% during the pandemic and many governments made national recommendations to delay nonurgent endoscopic procedures, leading to decrements of 22% in combined esophagogastroduodenoscopy (EGD) and colonoscopy and 20% in EGD after the COVID-19 pandemic. The symptoms and signs of COVID-19-related AP are fever (63%), abdominal pain (58%), respiratory symptoms (40%), nausea and vomiting (39%), and headache (4%). Approximately 5-10% of patients develop necrotizing or hemorrhagic AP, and patients who required surgical intervention had a higher mortality risk. Compared to 2019, the rates of elective surgery decreased by 41.8% in 2020; including cholecystectomy (40.1% decrease) and pancreas (111.1% decrease). Surgical volumes also decreased by 18.7% in 2020; device-assisted laparoscopic and robot-assisted procedures reduced by 45.4% and 61.9% during the COVID-19 Lockdown in 2020.

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SARS-CoV-2 infection is associated with an increased risk of idiopathic acute pancreatitis but not pancreatic exocrine insufficiency or diabetes: long-term results of the COVIDPAN study

Cited by 12 publications

References 10 publications

The bidirectional association between diabetes and long-COVID-19 – A systematic review

The bidirectional association between diabetes and long-COVID-19 – A systematic review

SARS-CoV-2 pandemic has impacted on patterns of aetiology for acute pancreatitis and management of gallstone pancreatitis in the UK

Surgical intervention for acute pancreatitis in the COVID-19 era

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