SARS‐CoV‐2 infection in patients with atopic dermatitis: a cross‐sectional study

Nguyen, Cristina; Yale, Katerina; Casale, Fiore; Ghigi, Alessandro; Zheng, Kai; Silverberg, J.I.; Mesinkovska, Natasha Atanaskova

doi:10.1111/bjd.20435

Cited by 17 publications

(12 citation statements)

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“…AD patients may be more susceptible to acquiring SARS-CoV-2 infection [3], though findings are inconclusive [5]. Current evidence indicates that AD patients are not at increased risk of mechanical ventilation [3,4], hospitalization [2], longer hospital stay [4], intensive care unit admission [4] or death [2,4]. In one retrospective study, AD was inversely associated with COVID-19 hospitalization [1].…”

Section: Discussionmentioning

confidence: 99%

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Atopic dermatitis is not associated with SARS-CoV-2 outcomes

et al. 2021

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Atopic dermatitis is characterized by immune dysregulation, which may predispose toward worse COVID-19 outcomes. We conducted a retrospective cohort study to investigate the relationship of atopic dermatitis with COVID-19 symptom severity, hospitalization, length of hospital stay, requirement for oxygen therapy, long-term morbidity and mortality. Multivariable logistic regression models were constructed to examine the impact of atopic dermatitis (independent variable) on COVID-19 symptom severity, hospitalization, length of hospital stay, requirement for oxygen therapy, long-term morbidity and mortality (dependent variables). SARS-CoV-2 positive adult patients with diagnosed AD had similar odds of hospitalization (adjusted odds ratio [95% confidence interval]: 0.51 [0.20-1.35]), acute level of care at initial medical care (0.67 [0.35-1.30]), severecritical SARS-CoV-2 (0.82 [0.29-2.30]), requirement of supplemental non-mechanical oxygen therapy (1.33 [0.50-3.58]), extended hospital stay (2.24 [0.36-13.85]), lingering COVID-19 symptoms (0.58 [0.06-5.31]) and COVID-19 death (0.002 [< 0.001-> 999]) compared to patients without AD. Our findings suggest AD is not an independent risk factor for COVID-19 severity or complications.

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Section: Discussionmentioning

confidence: 99%

“…asthma and rhinitis. Concern exists regarding potential for poorer COVID-19 outcomes in AD patients, though previous studies had mixed findings [1][2][3][4][5]. We investigated the relationship between AD and COVID-19 outcomes in adults.…”

Section: Introductionmentioning

confidence: 99%

Atopic dermatitis is not associated with SARS-CoV-2 outcomes

et al. 2021

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“…However, this study did not control for potential confounding variables. 6 Another retrospective cohort study looking specifically at 238 AD patients treated with dupilumab found no significant difference in infection rates or COVID-19 outcomes compared with AD patients on other systemic therapies such as systemic corticosteroids, phototherapy, or azathioprine and mycophenolate mofetil. 4 Finally, in a retrospective study that included 18,360 AD patients, the odds ratio of COVID-19 infection in AD patients after adjustment for comorbidities was 1.48 (95% CI, 1.06-2.06; P = .020).…”

Section: Discussionmentioning

confidence: 99%

“…For example, inconsistent data in the literature concerning COVID-19 infection rates in AD patients, with some studies finding an increased incidence of infection and others showing no significant difference. [5][6][7] Here, we aim to evaluate the association between AD and COVID-19 infection among adults in the All of Us research program, a National Institutes of Health database with health data from over 250,000 Americans, focusing on populations that have traditionally been underrepresented in research. 8 We compared comorbidities between cases and controls using Pearson's x 2 test or Fisher's exact test for categorical variables and the unpaired t test for continuous variables.…”

Section: Introductionmentioning

confidence: 99%

Association between atopic dermatitis and COVID-19 infection: A case-control study in the All of Us research program

et al. 2022

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Background There is incomplete understanding of the risk of coronavirus disease 2019 (COVID-19) infection in atopic dermatitis (AD) patients. Objective To evaluate the risk of COVID-19 infection in AD patients in a large, diverse cohort. Methods A case-control study of the All of Us cohort to analyze the association between AD and COVID-19. Comorbidities and risk factors were compared between cases and controls using multivariable analyses. Results In a cohort of 11,752 AD cases with 47,008 matched controls, AD patients were more likely to have a COVID-19 diagnosis (4.2% vs. 2.8%, P <0.001) compared to controls. AD remained significantly associated with COVID-19 in multivariable analysis (OR 1.29, P <0.001) after adjusting for demographic factors and comorbidities. Limitations Ascertainment of AD and COVID-19 cases using electronic health records and lack of clinical data on AD severity or therapy and COVID-19 outcomes. Conclusions AD is associated with increased odds of COVID-19 infection even after controlling for common comorbidities.

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“…Un appel à une sélection plus rigoureuse par les comités de lecture a été lancé fin 2020, observant que le délai d’acceptation des articles (moins de 24 heures pour certains) était bien inférieur aux délais habituels des 5 plus grands journaux de dermatologie [ 1 ]. Les infections COVID ne semblent pas plus sévères ou plus fréquentes chez les patients atteints de dermatoses inflammatoires chroniques, traités ou non par biologiques ou méthotrexate, sauf en cas de corticothérapie systémique ou de traitement par rituximab [ [2] , [3] , [4] , [5] , [6] , [7] ].…”

Section: Covid Et Peauunclassified

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2021

Annales de Dermatologie et de Vénéréologie - FMC

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SARS‐CoV‐2 infection in patients with atopic dermatitis: a cross‐sectional study

Cited by 17 publications

References 6 publications

Atopic dermatitis is not associated with SARS-CoV-2 outcomes

Atopic dermatitis is not associated with SARS-CoV-2 outcomes

Association between atopic dermatitis and COVID-19 infection: A case-control study in the All of Us research program

Quoi de neuf en dermatologie clinique ?

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