Association between atopic dermatitis and COVID-19 infection: A case-control study in the All of Us research program

Fan, Ryan; Leasure, Audrey C; Damsky, William; Cohen, Jeffrey M.

doi:10.1016/j.jdin.2021.12.007

Cited by 18 publications

(12 citation statements)

References 24 publications

(23 reference statements)

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“…AD, a form of eczema, is an allergic skin disease often related to asthma, food allergy, allergic conjunctivitis, and AR 29 . In observational studies, the relationship between AD and COVID-19 remained murkier: some studies [30][31][32] suggested that AD was associated with increased risk for COVID-19, while others suggested that it was associated with reduced risk [33][34][35] or had no effect 36 . Cohort studies have shown a reduced risk of SARS-CoV-2 infection in patients with AD treated with Dupilumab 35 .…”

Section: Discussionmentioning

confidence: 99%

Allergic disease as a causal protective factor for severe covid-19: a multivariable mendelian randomization study

2023

Preprint

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Allergic diseases were recently reported related to both SARS-CoV-2 infection and severe COVID-19 through observational studies. However, their causal relationship remains unclear. Herein, we performed univariate and multivariate Mendelian randomization (MR) studies to investigate the causal association between various allergic diseases and COVID-19. Genome-wide association studies (GWAS) summaries were used in this study, with 360838 participants in the allergic disease database, 455449 in asthma, 217914 in allergic rhinitis (AR), and 205764 in atopic dermatitis (AD). In univariate MR analysis, the allergic disease was not causally in connection with SARS‐CoV‐2 infection but have a causal protective effect on severe COVID-19. In contrast, no significant causal effect was found of SARS-CoV-2 infection/severe COVID-19 on the allergic disease. AD, mixed asthma, and childhood asthma were causal protective factors for severe COVID-19. Multivariate MR analysis further revealed the dominant role of asthma in allergic diseases and the dominance of childhood asthma in asthma subtypes. In summary, this study, based on the population genetic variation model, pointed out the protective effect of allergic diseases against severe COVID-19, which may provide some inspiration for further exploration of the pathophysiological mechanisms of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Allergic disease as a causal protective factor for severe covid-19: a multivariable mendelian randomization study

2023

Preprint

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“…Studies did not demonstrate atopic dermatitis as a key independent risk factor to developing severe SARS-CoV-2 infection ( 5 – 7 ). However, more recent studies established that AD is associated with an increased odds of COVID-19 infection even after controlling for common comorbidities ( 8 , 9 ). A systematic review evaluating cutaneous manifestations in patients infected with COVID-19 have shown that 20% of these patients had an underlying dermatologic disease including atopic dermatitis ( 10 ).…”

Section: Atopic Dermatitismentioning

confidence: 99%

Navigating patients with atopic dermatitis or chronic spontaneous urticaria during the COVID-19 pandemic

2022

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A rapid spread of different strains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented pandemic. Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, the medical body has encountered major obstacles concerning disease management at different levels. Even though patients infected with this virus mainly present with respiratory symptoms, it has been associated with a plethora of well-documented cutaneous manifestations in the literature. However, little investigations have been conducted concerning COVID-19 and its impact on skin disorders mediated by type 2 inflammation leaving multiple dermatologists and other specialists perplexed by the lack of clinical guidelines or pathways. This review focuses on the effects of this pandemic in patients with skin disorders mediated by type 2 inflammation, specifically atopic dermatitis and chronic spontaneous urticaria. In addition, it will provide clinicians a guide on treatment and vaccination considerations for this stated set of patients.

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“…Atopic dermatitis is considered a Th2-balanced disease often associated with bronchial asthma, allergic rhinitis, allergic conjunctivitis, and food allergy [ 55 ]. Atopic dermatitis has been reported to be associated with an increased risk of COVID-19 in some research [ 56 , 57 , 58 ] and with decreased risk [ 59 , 60 , 61 ] or no difference in other studies [ 60 , 61 , 62 ].…”

Section: Inflammation Exacerbates Covid-19 Infectionmentioning

confidence: 99%

Inflammation Causes Exacerbation of COVID-19: How about Skin Inflammation?

Komine

Ansary

Hossain

et al. 2022

IJMS

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COVID-19 is a recently emerged viral infection worldwide. SARS-CoV-2, the causative virus, is believed to have emerged from bat coronaviruses, probably through host conversion. The bat coronavirus which has the highest gene homology to SARS-CoV-2 specifically infects deep forest bats in China whose habitat extends through the Middle East to Southern Europe. Host conversion might have occurred due to the deforestation by humans exposing wild bats to the environment they had never encountered before. SARS-CoV-2 infects cells through two mechanisms: through its receptor ACE2 with the help of enzyme TMPRSS and through membrane fusion with the help of elastases in the inflammatory condition. Obesity, hypertension, diabetes mellitus, and pulmonary diseases cause poor prognosis of COVID-19. Aging is another factor promoting poor prognosis. These diseases and aging cause low-level and persistent inflammation in humans, which can promote poor prognosis of COVID-19. Psoriasis and atopic dermatitis are the major inflammatory skin diseases. These inflammatory skin conditions, however, do not seem to cause poor prognosis for COVID-19 based on the epidemiological data accumulated so far. These mechanisms need to be elucidated.

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Association between atopic dermatitis and COVID-19 infection: A case-control study in the All of Us research program

Cited by 18 publications

References 24 publications

Allergic disease as a causal protective factor for severe covid-19: a multivariable mendelian randomization study

Allergic disease as a causal protective factor for severe covid-19: a multivariable mendelian randomization study

Navigating patients with atopic dermatitis or chronic spontaneous urticaria during the COVID-19 pandemic

Inflammation Causes Exacerbation of COVID-19: How about Skin Inflammation?

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