Navigating patients with atopic dermatitis or chronic spontaneous urticaria during the COVID-19 pandemic

Haddad, Isabelle; Kozman, Kathia; Kibbi, Abdul‐Ghani

doi:10.3389/falgy.2022.809646

Cited by 6 publications

(6 citation statements)

References 38 publications

(110 reference statements)

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“…Dermatologists should be aware of these reactions to be able to provide proper patient education and shed light on appropriate management during the COVID‐19 pandemic. A recent review on COVID‐19 in patients with atopic dermatitis and chronic spontaneous urticaria revealed that flare‐ups are common 36 …”

Section: Discussionmentioning

confidence: 99%

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Dermatological manifestations associated with COVID‐19 and COVID‐19 vaccination: results from the Lebanese COVID registry

Chrabieh,

Haddad,

Salameh

et al. 2023

Int J Dermatology

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BackgroundA number of cutaneous manifestations and adverse cutaneous reactions have been associated with COVID‐19 infection and vaccine.ObjectivesA Lebanese national registry was established to characterize the dermatologic manifestations and adverse cutaneous reactions associated with COVID‐19 infection and vaccination in a sample of the Lebanese population.MethodsAn observational cross‐sectional study was conducted via a web‐based clinical form distributed to physicians wishing to report their cases from May 2021 till May 2022.ResultsIn total, 142 patients were entered in the registry, of which 133 were adults and nine were pediatric patients. The main dermatological manifestations reported with COVID‐19 infection in the adult group were urticaria (32.9%), telogen effluvium (21.4%), morbilliform (10%), and papulosquamous (8.6%) eruptions. Urticaria was the most common adverse cutaneous reaction to the vaccine (33%). Interestingly, herpes zoster was triggered in 12 patients post vaccination in our series with this finding more frequently seen in patients above the age of 41 (P = 0.013). In the pediatric group, the most reported dermatological findings associated with COVID‐19 infection were malar erythema (25%) and telogen effluvium (25%). One 16‐year‐old patient developed lichen planus after one dose of a COVID‐19 vaccine. No deaths were reported in both age groups.ConclusionThis Lebanese registry adds more robust evidence that clinical manifestations of the COVID‐19 virus and vaccine are diverse. More studies are necessary to establish the pathophysiology of these dermatological findings in the context of COVID‐19 infection and vaccination.

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Section: Discussionmentioning

confidence: 99%

“…A recent review on COVID-19 in patients with atopic dermatitis and chronic spontaneous urticaria revealed that flare-ups are common. 36 The advent of COVID-19 vaccines offered a glimpse of hope to fight the pandemic. However, there have been numerous reports of ACRs post-vaccine administration.…”

Section: Discussionmentioning

confidence: 99%

Dermatological manifestations associated with COVID‐19 and COVID‐19 vaccination: results from the Lebanese COVID registry

Chrabieh,

Haddad,

Salameh

et al. 2023

Int J Dermatology

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“…Further confirmation of the antiviral potential of photochemotherapy comes from the finding of photoinactivation potential in plasma with Amotosalen and 3 J/cm 2 of UVA light of six RNA-enveloped viruses, including SARS CoV [ 57 ]. Beyond the newly explored therapeutic potential, the promising role of phototherapy is also related to its choice as a viable therapeutic alternative to immunomodulating/immunosuppressive drugs used in AD and similar conditions whose use should be limited because of their ability to impact vaccine-induced immune responses [ 58 , 59 , 60 , 61 ] and for their suppressive action on intrinsic antiviral immunity [ 62 , 63 , 64 ] except for dupilumab, whose evidence of use in the pandemic era is reassuring [ 65 , 66 , 67 ].…”

Section: Atopic Dermatitis Treatmentmentioning

confidence: 99%

Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

et al. 2022

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Atopic dermatitis is a chronic inflammatory skin disease in which the overproduction of reactive oxygen species plays a pivotal role in the pathogenesis and persistence of inflammatory lesions. Phototherapy represents one of the most used therapeutic options, with benefits in the clinical picture. Studies have demonstrated the immunomodulatory effect of phototherapy and its role in reducing molecule hallmarks of oxidative stress. In this review, we report the data present in literature dealing with the main signaling molecular pathways involved in oxidative stress after phototherapy to target atopic dermatitis-affected cells. Since oxidative stress plays a pivotal role in the pathogenesis of atopic dermatitis and its flare-up, new research lines could be opened to study new drugs that act on this mechanism, perhaps in concert with phototherapy.

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“…It affects approximately 10% of the population [ 127 ]. Most often, atopic dermatitis occurs in early childhood, also in infancy, and manifests itself as a rash with redness and dryness of the skin, as well as severe itching [ 128 , 129 ]. Patients tend to scratch skin lesions, which leads to numerous bacterial superinfections and exacerbates the lesions, causing discomfort and negatively affecting the patients’ quality of life [ 127 ].…”

Section: Introductionmentioning

confidence: 99%

The most common skin symptoms in young adults and adults related to SARS-CoV-2 virus infection

Zaborska,

Chruszcz,

Sadowski

et al. 2024

Arch Dermatol Res

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Scientists from various areas of the world indicate in their studies that skin lesions occur in the course of infection with the SARS-CoV-2 virus. This article is a review of the most frequently described cutaneous manifestations of SARS-CoV-2 virus infection and the potential pathophysiology of their development, as well as information on abnormalities in histopathological tests. The article describes the impact of some factors related to the COVID-19 pandemic on the exacerbation of chronic dermatological diseases. This work was constructed on the basis of 142 research studies, reviews, and meta-analyses, focusing on the methods and materials used in individual works as well as the results and conclusions resulting from them. Some skin lesions may be a potential prognostic marker of the course of the disease and may also be a prodromal symptom or the only symptom of SARS-CoV-2 virus infection. Stress related to the COVID-19 pandemic may exacerbate some chronic dermatological diseases. A correlation was observed between the type of skin lesions and the patient’s age. The occurrence of skin diseases may also be influenced by drugs used to treat infections caused by SARS-CoV-2. A relationship was observed between the patient’s ethnic origin and skin lesions occurring in the course of COVID-19. There is a need to further diagnose the cutaneous manifestations of SARS-CoV-2 infection and to learn the detailed pathomechanism of their occurrence in order to better understand the essence of the disease and find an appropriate treatment method.

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Navigating patients with atopic dermatitis or chronic spontaneous urticaria during the COVID-19 pandemic

Cited by 6 publications

References 38 publications

Dermatological manifestations associated with COVID‐19 and COVID‐19 vaccination: results from the Lebanese COVID registry

Dermatological manifestations associated with COVID‐19 and COVID‐19 vaccination: results from the Lebanese COVID registry

Oxidative Stress and Phototherapy in Atopic Dermatitis: Mechanisms, Role, and Future Perspectives

The most common skin symptoms in young adults and adults related to SARS-CoV-2 virus infection

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