SARS-CoV-2 in Pregnancy: A Comprehensive Summary of Current Guidelines

Narang, Kavita; Ibirogba, Eniola R.; Elrefaei, Amro; Trad, Ayssa Teles Abrão; Theiler, Regan N.; Nomura, Roseli Mieko Yamamoto; Picone, Olivier; Kilby, Mark D.; Escuriet, Ramón; Suy, Anna; Carreras, E.; Tonni, Gabriele; Ruano, Rodrigo

doi:10.3390/jcm9051521

Cited by 58 publications

(123 citation statements)

References 4 publications

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“…For this reason governments have taken precautions like lockdown, social distancing, compulsory use of personal protective equipments and comprehensive regulations in healthcare policies [ 2 ]. Moreover, health authorities all over the world have prepared guidelines and management protocols to control the disease [ 3 ]. On the other hand, no consensus has been reached on the optimal COVID-19 screening policy, procedure specific precautions for healthcare workers and treatment modalities for infected patients.…”

Section: Introductionmentioning

confidence: 99%

The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey

Tanaçan

Erol

Turgay

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective To investigate the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity in asymptomatic pregnant women admitted to hospital for delivery in a Turkish pandemic center. Study Design This prospective cohort study was conducted in Ankara City Hospital between April, 15, 2020 and June, 5, 2020. A total of 206 asymptomatic pregnant women (103 low-risk pregnant women without any defined risk factor and 103 high-risk pregnant women) were screened for SARS-CoV-2 positivity upon admission to hospital for delivery. Detection of SARS-CoV2 in nasopharyngeal and oropharyngeal samples was performed by Real Time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) method targeting RdRp (RNA dependent RNA polymerase) gene. Two groups were compared in terms of demographic features, clinical characteristics and SARS-CoV-2 positivity. Results Three of the 206 pregnant women participating in the study had positive RT-PCR tests (1.4 %) and all positive cases were in the high-risk pregnancy group. Although, one case in the high-risk pregnancy group had developed symptoms highly suspicious for COVID-19, two repeated RT-PCR tests were negative. SARS-CoV-2 RT-PCR positivity rate was significantly higher in the high-risk pregnancy group (2.9 % vs 0%, p = 0.04). Conclusion Healthcare professionals should be cautious in the labor and delivery of high-risk pregnant women during the pandemic period and universal testing for COVID-19 may be considered in selected populations.

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Section: Introductionmentioning

confidence: 99%

The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey

Tanaçan

Erol

Turgay

et al. 2020

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Despite the large and rapidly rising number of cases of COVID-19, data concerning clinical characteristics of pregnant women with the disease are limited [9]. The aim of this study was to evaluate the laboratory characteristics of pregnant women with SARS-CoV-2 infection compared to infected non-pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Laboratory characteristics of pregnant compared to non-pregnant women infected with SARS-CoV-2

Mohr–Sasson

Chayo

Bart

et al. 2020

Arch Gynecol Obstet

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Key message Laboratory characteristics of SARS-CoV-2 infection did not differ between pregnant and non-pregnant women. A trend of lower lymphocyte count was observed in the pregnant women group Purpose Laboratory abnormalities, which characterize SARS-CoV-2 infection have been identified, nevertheless, data concerning laboratory characteristics of pregnant women with SARS-CoV-2 are limited. The aim of this study is to evaluate the laboratory characteristics of pregnant compared to non-pregnant women with SARS-CoV-2 infection. Methods A retrospective cohort study of all pregnant women with SARS-CoV-2 who were examined at the obstetric emergency room in a tertiary medical center between March and April 2020. Patients were compared with non-pregnant women with SARS-CoV-2 matched by age, who were examined at the general emergency room during the study period. All patients were confirmed for SARS-CoV-2 on admission. Clinical characteristics and laboratory results were compared between the groups. Results Study group included 11 pregnant women with SARS-CoV-2, who were compared to 25 non-pregnant controls. Respiratory complaints were the most frequent reason for emergency room visit, and were reported in 54.5% and 80.0% of the pregnant and control groups, respectively (p = 0.12). White blood cells, hemoglobin, platelets, and liver enzymes counts were within the normal range in both groups. Lyphocytopenia was observed in 45.5% and 32% of the pregnant and control groups, respectively (p = 0.44). The relative lymphocyte count to WBC was significantly reduced in the pregnant group compared to the controls [13.6% (4.5-19.3) vs. 26.5% (15.7-29.9); p = 0.003]. C-reactive protein [20(5-41) vs. 14 (2-52) mg/dL; p = 0.81] levels were elevated in both groups but without significant difference between them. Conclusion Laboratory characteristics of SARS-CoV-2 infection did not differ between pregnant and non-pregnant women, although a trend of lower lymphocyte count was observed in the pregnant women group.

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“…A comprehensive review of care guidelines from international perinatal societies and institutions found that most either recommended no visitors or one asymptomatic support person, and expedited discharge was recommended by the American College of Obstetrics and Gynecology, the Catalan Health Service, and the Society for Maternal and Fetal Medicine. 37…”

Section: Labor and Deliverymentioning

confidence: 99%

The Impact of the COVID-19 Pandemic on Maternal and Perinatal Health: A Scoping Review

Kotlar

Gerson

Petrillo

et al. 2020

Preprint

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Introduction: Maternal health is a critical public health issue, and the Coronavirus Disease 2019 (COVID-19) pandemic has had a multifaceted impact on the health and wellbeing of pregnant individuals and mothers. Methods: A scoping review was conducted to compile evidence on direct and indirect impacts of the pandemic on maternal health and provide an overview of the most significant outcomes thus far. Working papers and news articles were considered appropriate evidence along with peer-reviewed publications in order to capture rapidly evolving updates. Narrative descriptions were written about subject areas for which the authors found the most evidence.Results: While the search yielded numerous publications, most studies were methodologically weak. Pregnant individuals were not found to experience more severe symptoms than the general population, and intrauterine, vertical, and breastmilk transmission were unlikely. Labor, delivery, and breastfeeding guidelines for COVID-19 positive patients varied. Severe increases in maternal mental health issues, such as clinically relevant anxiety and depression, were reported. Domestic violence appeared to spike. Prenatal care visits decreased, healthcare infrastructure was strained, and potentially harmful policies implemented with little evidence. Women were more vulnerable to losing their income due to the pandemic than men, and working mothers struggled with increased childcare demands. Conclusion:Pregnant women and mothers were not found to be at higher risk for COVID-19 than the general population, however they seem to face disproportionate adverse socio-economic consequences. High income and low- and middle-income countries alike faced significant struggles. Further resources should be directed towards quality epidemiological studies.

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SARS-CoV-2 in Pregnancy: A Comprehensive Summary of Current Guidelines

Cited by 58 publications

References 4 publications

The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey

The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey

Laboratory characteristics of pregnant compared to non-pregnant women infected with SARS-CoV-2

The Impact of the COVID-19 Pandemic on Maternal and Perinatal Health: A Scoping Review

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