The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey

Tanaçan, Atakan; Erol, Seyit Ahmet; Turgay, Batuhan; Anuk, Ali Taner; Seçen, Elçin İşlek; Akçay, Güngör; Özyer, Şebnem; Kırca, Fisun; Dinç, Bedia; Unlu, Serpil; Eyı, Elif Gül Yapar; Keskin, Hüseyin Levent; Şahın, Dilek; Surel, Aziz Ahmet; Tekın, Özlem Moraloğlu

doi:10.1016/j.ejogrb.2020.07.051

Cited by 45 publications

(42 citation statements)

References 15 publications

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“…Pathological examinations have showed that syncytiotrophoblasts are often infected with SARS‐CoV‐2, however, transmission in the fetus has not always been detected. Mulvey et al demonstrated fetal vascular malperfusion with multiple thromboses in placentas from COVID‐19 patients who delivered at term 6 . Nevertheless, there have been on‐going arguments about the vertical transmission of COVID‐19 and this issue has not been clarified, yet.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, with the ease of accessibility to polymerase chain reaction (PCR) tests, an increase in the number of asymptomatic cases has been observed. However, increased antenatal follow‐up frequency of pregnant women in high risk group and more contact with the hospital setting explain the high positive rates seen in these pregnant women 6 …”

Section: Introductionmentioning

confidence: 99%

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Doppler assessment of the fetus in pregnant women recovered from COVID‐19

Anuk

Yetiskin

Buyuk

et al. 2021

J of Obstet and Gynaecol

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Objective The aim of this study was to evaluate the maternal‐fetal Doppler patterns in pregnant women recovered from COVID‐19. Methods This prospective case–control study was conducted in Ankara City Hospital between July 1, 2020 and August 30, 2020. Thirty pregnant women who were diagnosed with COVID‐19 and completed the quarantine process were compared with 40 healthy pregnant women in terms of the fetal Doppler parameters. All pregnant women diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection were followed up in our clinic and their diagnoses have been confirmed in nasopharyngeal and oropharyngeal samples by quantitative real time reverse transcriptase polymerase chain reaction (RT‐PCR) method. Doppler ultrasonographic assessment of the uterine arteries (UtA) and middle cerebral artery (MCA) were used in addition to umbilical artery (UA) Doppler between 23 and 40 weeks of gestation. Also, cerebroplacental ratio (CPR) was calculated according to gestational age. Results The pulsatility and resistance indices of umbilical and UtA showed a significant increase in pregnant women in the study group compared to the control group ( p < 0.05). Multivariable logistic regression analysis revealed that pulsatility and resistance indices of the mean UtA were independently associated with disease (OR > 1000, 95%CI 9.77 to >1000, p = 0.009; OR 0,000 95%CI 0,000‐0,944, p = 0,049), respectively. Medical treatment was given to 16/30 (53%) of pregnant women diagnosed with COVID‐19. Conclusion In conclusion, uterine artery Doppler indices in the third trimester may have clinical value in pregnant women recovered from COVID‐19.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Doppler assessment of the fetus in pregnant women recovered from COVID‐19

Anuk

Yetiskin

Buyuk

et al. 2021

J of Obstet and Gynaecol

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“…In the present study, the COVİD-19 positivity rate was 11,4% among women with early pregnancy loss, and asymptomatic positive patient rate was 9,5%. In another study conducted in the same center between April and June 2020, asymptomatic positive patient rate among pregnant women was 1,4% [ 25 ]. Although it is not appropriate to make a comparison due to the fact that the two studies were not conducted in the same period, the difference in COVID 19 positivity rate between women with pregnancy loss and pregnant women is remarkable.…”

Section: Discussionmentioning

confidence: 99%

Investigating the risk of maternal-fetal transmission of SARS-CoV-2 in early pregnancy

et al. 2021

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Introduction The possibility of vertical transmission of SARS-CoV-2 from the mother to the fetus is one of the most crucial issues regarding the COVID-19 effects on pregnancy. In this study, we aimed to explore the risk of maternal-fetal transmission before 24 weeks of gestation, through analysis of abortion materials collected from PCR-positive women with pregnancy loss. To the best of our knowledge, apart from case reports, this study is the first prospective work on the vertical transmission of SARS-CoV-2 in early pregnancy. Methods The patients who had attended our clinic with the diagnosis of pregnancy loss before 24 weeks of gestation were screened for COVİD-19. Vertical transmission in PCR-positive women was assessed through the presence of SARS-CoV-2 RNA in fetal-placental tissues by rt-PCR test. Results 24 of 210 (%11,4) pregnant women participating in the study had positive rt-PCR results. Placenta and curettage material samples of these PCR-positive patients were analyzed and all valid test results (21 samples) were negative for SARS CoV-2 RNA. In three cases, the rt-PCR results were invalid due to failed internal controls.

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“…COVID‐19 was diagnosed by a real‐time polymerase chain reaction assay on the nasopharyngeal and oropharyngeal specimens 15 . The severity of disease and management of the cases with COVID‐19 were determined according to the national guidelines 16 .…”

Section: Methodsmentioning

confidence: 99%

Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes

Erol

Tanaçan

Anuk

et al. 2020

Journal of Medical Virology

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To evaluate the maternal serum afamin and vitamin E levels in pregnant women with coronavirus disease 2019 (COVID‐19) and to investigate their association with composite adverse perinatal outcomes. This prospective, case‐control study consisted of 60 pregnant women with COVID‐19 infection and 36 age‐matched pregnant women without any defined risk factors. Demographic features, laboratory test results, afamin and vitamin E levels were compared between the groups. A receiver operating characteristic (ROC) curve was used to assess the relationship of afamin and vitamin E levels in predicting composite adverse perinatal outcomes. A correlation analysis was performed between afamin and C‐reactive protein (CRP) levels in pregnant women with COVID‐19. The obstetric complication rate was higher in the COVID‐19 group (13.3% vs. 2.8%) (p = .01). Afamin levels were higher and vitamin E levels were lower in the COVID‐19 group (p = .02 and p < .001, respectively). Vitamin E levels were lower in the COVID‐19 group for the all trimesters (p < .001, p < .001, and p = .004, respectively). Afamin levels were higher in the COVID‐19 group for the all trimesters without reaching statistical significance (p > .05). The values in the ROC curves with the best balance of sensitivity/specificity for afamin and vitamin E were 0.424 mg/l (70.6% sensitivity, 44.3% specificity) and 3.150 µg/ml (76.5% sensitivity, 58.2% specificity), respectively. A positive moderate statistically significant correlation was found between afamin and CRP levels (r = .264, p = .009). Higher afamin and lower vitamin E levels may support the elevated oxidative stress in the etiopathogenesis of COVID‐19 and the relationship with composite adverse perinatal outcomes.

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The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey

Cited by 45 publications

References 15 publications

Doppler assessment of the fetus in pregnant women recovered from COVID‐19

Doppler assessment of the fetus in pregnant women recovered from COVID‐19

Investigating the risk of maternal-fetal transmission of SARS-CoV-2 in early pregnancy

Evaluation of maternal serum afamin and vitamin E levels in pregnant women with COVID‐19 and its association with composite adverse perinatal outcomes

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