SARS-CoV-2 detection and sequencing in heart tissue associated with myocarditis and persistent arrhythmia: A case report

Egas, Diego; Guadalupe, Juan José; Prado-Vivar, Belén; Becerra-Wong, Mónica; Márquez, Sully; Castillo, Stalin; Latta, Johanna; Rodríguez, Francisco Javier Yate; Escorza, Giovanni; Trueba, Gabriel; Grunauer, Michelle; Barragán, Verónica; Rojas-Silva, Patricio; Cárdenas, Paúl

doi:10.1016/j.idcr.2021.e01187

Cited by 7 publications

(7 citation statements)

References 12 publications

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Section: Resultsmentioning

confidence: 99%

“…Table 2 presents the baseline demographics, diagnostic findings, and chief features of COVID‐19 patients who developed bradycardia from the individual cases compiled ( n = 59). 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 Bradycardia predominated in male patients ( n = 37) with a median age of 58.0 years old (IQR 48.0−71.0). Bradycardia was most often observed in patients classified as having severe or critical illness COVID‐19 (35.6% and 32.2%, respectively).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of bradyarrhythmia in patients with COVID‐19: Systematic scoping review

Nagamine

Randhawa

Nishimura

et al. 2022

Pacing Clinical Electrophis

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COVID-19 has recently been associated with the development of bradyarrhythmias, although its mechanism is still unclear. We aim to summarize the existing evidence regarding bradyarrhythmia in COVID-19 and provide future directions for research.Following the PRISMA Extension for Scoping Reviews, we searched MEDLINE and EMBASE for all peer-reviewed articles using keywords including"Bradycardia," "atrioventricular block," and "COVID-19″ from their inception to October 13, 2021. Fortythree articles, including 11 observational studies and 59 cases from case reports and series, were included in the systematic review. Although some observational studies reported increased mortality in those with bradyarrhythmia and COVID-19, the lack of comparative groups and small sample sizes hinder the ability to draw definitive conclusions. Among 59 COVID-19 patients with bradycardia from case reports and series, bradycardia most often occurred in those with severe or critical COVID-19, and complete heart block occurred in the majority of cases despite preserved LVEF (55.9%).Pacemaker insertion was required in 76.3% of the patients, most of which were permanent implants (45.8%). This systematic review summarizes the current evidence and characteristics of bradyarrhythmia in patients with COVID-19. Further studies are critical to assess the reversibility of bradyarrhythmia in COVID-19 patients and to clarify potential therapeutic targets including the need for permanent pacing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Characteristics of bradyarrhythmia in patients with COVID‐19: Systematic scoping review

Nagamine

Randhawa

Nishimura

et al. 2022

Pacing Clinical Electrophis

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“…1 According to this, the organs of the respiratory system are mainly affected, 2 although recent studies, using the electron microscopy method, have demonstrated direct damage of the heart with the presence of viral particles in the myocardium. 3,4 The described clinical and morphological patterns of heart damage include myocardial ischemic injury and acute coronary syndrome, acute myocarditis, or progressive heart failure by the left or right ventricular type up to cardiogenic shock with a prevalence of up to 10% among the general population of patients with COVID-19 and up to 41% among patients with an extremely severe course of infection. 5,6 At the same time, the available information is often discordant in terms of the prevailing patterns of heart damage and its consequences.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of VDR in Myocardium: Postmortem Evaluation of COVID-19 Patients

Kriventsov

Yermola

Davydova

et al. 2022

J Histochem Cytochem.

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Morphological data on heart damage and its mechanisms due to extremely severe course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are limited, as well as data on the correlation of damage and expression of vitamin D receptors (VDRs). In this study, we analyzed a series of myocardial samples obtained during postmortem autopsy of 48 critically ill patients with COVID-19 who died with SARS-CoV-2-associated pneumonia. The purpose of the study was to evaluate immunohistochemical VDR expression in the myocardium. The results showed the only minimal or no immunohistochemical expression of VDR in the nuclei of cardiomyocytes in most cases, along with the persisted strong expression in lymphoid cells. To the best of our knowledge, it is the first study and data provided were regarding myocardial VDR expression in COVID-19 patients. The results are of interest in terms of further study of the effects of ligand-associated VDR activation on the cardiovascular system.

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“…SARS-CoV-2, так же как и SARS-CoV, имеет ряд характерных признаков, основным из которых является способность связываться с рецепторами ангиотензинпревращающего фермента 2 (ACE2) на клеточных мембранах [2,3], что делает возможным прямое вирусное цитопатическое повреждение различных клеток, экспрессирующих этот рецептор. И действительно, в некоторых недавних исследованиях с использованием методов электронной микроскопии и иммуногистохимии было показано, что вирус оказывает прямое повреждающее действие на многие органы и ткани, включая сердце [4,5].…”

Section: Introductionunclassified

Myocardial lesions in patients with COVID-19. Autopsy case series

Ермола¹,

Galyshevskaya²,

Davydova³

et al. 2022

Clin. Exp. Morphology

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Introduction. Morphological data on SARS-CoV-2-associated heart damage and its mechanisms are rather limited. However, clinical and morphological features of myocardial lesions in COVID-19 patients have been described and include myocardial ischemia, acute coronary syndrome, and acute myocarditis. The prevailing features of myocardial lesions and their consequences are still controversial. The aim of our research was to evaluate the morphological features of myocardial lesions in patients with severe COVID-19, using routine histological examination and immunohistochemistry (CD45) to confirm myocardial inflam-matory infiltration. Materials and methods. We analyzed samples of the left ventricular myocardium obtained during autopsy examination of 48 patients with severe COVID-19 who died from SARS-CoV-2-associated pneumonia. We used histological description and immunohistochemical methods. Results. The results revealed several histopathological features of COVID-19-associated myocardial lesions, including acute ischemia (25% of cases) and mild inflammatory changes termed borderline myocarditis (18.75% of cases). Other significant findings in the myocardium included microcirculatory vessel thrombosis. Conclusion. The study confirms the existing data on damage to myocardium in severe COVID-19. However, further studies are warranted. It may contribute to the development of new management strategies for severe COVID-19 patients. Keywords: SARS-CoV-2, heart, ischemia, myocarditis

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SARS-CoV-2 detection and sequencing in heart tissue associated with myocarditis and persistent arrhythmia: A case report

Cited by 7 publications

References 12 publications

Characteristics of bradyarrhythmia in patients with COVID‐19: Systematic scoping review

Characteristics of bradyarrhythmia in patients with COVID‐19: Systematic scoping review

Immunohistochemical Expression of VDR in Myocardium: Postmortem Evaluation of COVID-19 Patients

Myocardial lesions in patients with COVID-19. Autopsy case series

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