SARS-CoV-2 and probable lung cancer risk

Khiali, Sajad; Rezagholizadeh, Afra; Entezari‐Maleki, Taher

doi:10.34172/bi.2022.23266

Cited by 6 publications

(9 citation statements)

References 15 publications

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“… 35 , 36 Pulmonary fibrosis may be a long-term complication of coronavirus-infected patients, which increases the risk for the development of lung cancer. 37 Increasing risk of long-term pulmonary complications was also observed in survivors of SARS-CoV-2 infection. However, methods for directly detecting latent virion in pulmonary tissue are very few.…”

Section: Discussionmentioning

confidence: 98%

“…Importantly, these methods are very effective and easy to use, as PET screening is not required. However, previous studies have reported long-term lung complications in patients infected with SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). , Pulmonary fibrosis may be a long-term complication of coronavirus-infected patients, which increases the risk for the development of lung cancer . Increasing risk of long-term pulmonary complications was also observed in survivors of SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

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A Positron Emission Tomography Tracer Targeting the S2 Subunit of SARS-CoV-2 in Extrapulmonary Infections

Xian

Huang

et al. 2022

Mol. Pharmaceutics

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Tracking the pathogen of coronavirus disease 2019 (COVID-19) in live subjects may help estimate the spatiotemporal distribution of SARS-CoV-2 infection in vivo . This study developed a positron emission tomography (PET) tracer of the S2 subunit of spike (S) protein for imaging SARS-CoV-2. A pan-coronavirus inhibitor, EK1 peptide, was synthesized and radiolabeled with copper-64 after being conjugated with 1,4,7-triazacyclononane-1,4,7-triyl-triacetic acid (NOTA). The in vitro stability tests indicated that [ 64 Cu]Cu-NOTA-EK1 was stable up to 24 h both in saline and in human serum. The binding assay showed that [ 64 Cu]Cu-NOTA-EK1 has a nanomolar affinity ( K i = 3.94 ± 0.51 nM) with the S-protein of SARS-CoV-2. The cell uptake evaluation used HEK293T/S + and HEK293T/S – cell lines that showed that the tracer has a high affinity with the S-protein on the cellular level. For the in vivo study, we tested [ 64 Cu]Cu-NOTA-EK1 in HEK293T/S + cell xenograft-bearing mice ( n = 3) and pseudovirus of SARS-CoV-2-infected HEK293T/ACE2 cell bearing mice ( n = 3). The best radioactive xenograft-to-muscle ratio ( X / N xenograft 8.04 ± 0.99, X / N pseudovirus 6.47 ± 0.71) was most evident 4 h postinjection. Finally, PET imaging in the surrogate mouse model of beta-coronavirus, mouse hepatic virus-A59 infection in C57BL/6 J mice showed significantly enhanced accumulation in the liver than in the uninfected mice (1.626 ± 0.136 vs 0.871 ± 0.086 %ID/g, n = 3, P < 0.05) at 4 h postinjection. In conclusion, our experimental results demonstrate that [ 64 Cu]Cu-NOTA-EK1 is a potential molecular imaging probe for tracking SARS-CoV-2 in extrapulmonary infections in living subjects.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A Positron Emission Tomography Tracer Targeting the S2 Subunit of SARS-CoV-2 in Extrapulmonary Infections

Xian

Huang

et al. 2022

Mol. Pharmaceutics

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“…Low ACE2 levels contribute to malignancies and poor prognostic cancers. 127 A comprehensive bioinformatic and systemic biological analysis identified 122 COVID-19/NSCLC interactional genes and 21 interactional hub genes. The enrichment analysis revealed common signaling pathways between COVID-19 and NSCLC.…”

Section: Lung Cancermentioning

confidence: 99%

“…Also, in NSCLC, downregulation of ACE2 was found to occur after COVID‐19 infection. Low ACE2 levels contribute to malignancies and poor prognostic cancers 127 . A comprehensive bioinformatic and systemic biological analysis identified 122 COVID‐19/NSCLC interactional genes and 21 interactional hub genes.…”

Section: Unveiling the Lethal Convergence: Exploring The Intersection...mentioning

confidence: 99%

COVID‐19 and cancer: Dichotomy of the menacing dilemma

Ghosh,

Tabassum,

Basu

2023

MedComm – Oncology

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The coronavirus disease 2019 (COVID‐19) pandemic brought about unprecedented challenges to global healthcare systems. Among the most vulnerable populations are cancer patients, who face dilemmas due to their compromised immune systems and the intricate interplay with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus. This comprehensive review delves into the multifaceted relationship between COVID‐19 and cancer. Through an analysis of existing literature and clinical data, this review unravels the structural intricacies of the virus and examines its profound implications for cancer patients, thereby bridging the knowledge gap between virology and oncology. The review commences with an introduction regarding the COVID‐19 pandemic and cancer. It then transitions into a detailed examination of the SARS‐CoV‐2 virus and its variants such as Alpha (PANGO lineage B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529 lineage). Subsequently, an insightful analysis of the impact of COVID‐19 on major cancer types (viz., Lung, Colon, Brain, and gastrointestinal cancer) is elaborated. Finally, the therapeutic avenues, oncological care, and management are discussed. The nexus between COVID‐19 and cancer adds a layer of complexity to patient care, emphasizing the importance of tailored approaches for those grappling with both conditions. Amid the landscape defined by the evolving viral strains, this review navigates through the multifaceted implications of COVID‐19 on cancer patients and underscores the significance of integrating virology and oncology.

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“…The key environmental types of biological pollutants include biological allergens (e.g., cat/dog dander and saliva, house dust mites, cockroaches, molds, and pollen) and microorganisms (viruses and bacteria) [ 14 ]. Several studies have shown that pathogenic microorganisms such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [ 15 , 16 ], human immunodeficiency virus (HIV) [ 17 ], human papillomavirus (HPV) [ 18 ], Epstein–Barr virus (EBV) [ 19 ], Helicobacter pylori ( H. pylori ) [ 20 ], Streptococcus pneumoniae ( S. pneumoniae ) [ 21 ], Mycobacterium tuberculosis ( M.tb ) [ 22 ], Chlamydia pneumoniae ( C. pneumoniae ) [ 23 ], and the common allergen house dust mite [ 24 ] are strongly associated with lung cancer. However, few studies have linked these pathogens/allergens to biological pollutants, and the concept of biological pollutants seems to be partially neglected in research on environmental pollutants and lung cancer, despite the extensive research into air pollution and lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

Wang,

Chan,

Zhang

et al. 2024

IJMS

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Environmental pollutants are closely linked to lung cancer. The different types of environmental pollutants can be classified as chemical, physical, and biological. The roles of common chemical and physical pollutants such as PM2.5, smoking, radon, asbestos, and formaldehyde in lung cancer have been extensively studied. Notably, the worldwide COVID-19 pandemic raised awareness of the strong link between biological pollution and human health. Allergens such as house dust mites and pollen, as well as bacteria and viruses, are common biological pollutants. A few biological pollutants have been reported to promote lung cancer via inducing inflammatory cytokines secretion, such as IL-1β, IL-6, and TGF-β, as well as suppressing immunosurveillance by upregulating regulatory T (Treg) cells while dampening the function of CD8+ T cells and dendritic cells. However, the correlation between common biological hazards, such as SARS-CoV-2, human immunodeficiency viruses, Helicobacter pylori, and house dust mites, and lung cancer is not fully elucidated, and the underlying mechanisms are still unclear. Moreover, the majority of studies that have been performed in lung cancer and biological carcinogens were not based on the perspective of biological pollutants, which has challenged the systematicity and coherence in the field of biological pollutants in lung cancer. Here, in addition to reviewing the recent progress made in investigating the roles of allergens, viruses, and bacteria in lung cancer, we summarized the potential mechanisms underlying biological pollutants in lung cancer. Our narrative review can shed light on understanding the significance of biological pollutants in lung cancer, as well as inspire and broaden research ideas on lung cancer etiology.

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SARS-CoV-2 and probable lung cancer risk

Cited by 6 publications

References 15 publications

A Positron Emission Tomography Tracer Targeting the S2 Subunit of SARS-CoV-2 in Extrapulmonary Infections

A Positron Emission Tomography Tracer Targeting the S2 Subunit of SARS-CoV-2 in Extrapulmonary Infections

COVID‐19 and cancer: Dichotomy of the menacing dilemma

Dark under the Lamp: Neglected Biological Pollutants in the Environment Are Closely Linked to Lung Cancer

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