SARS-CoV-2 and miRNA-like inhibition power

Demongeot, Jacques; Seligmann, Hervé

doi:10.1016/j.mehy.2020.110245

Cited by 21 publications

(23 citation statements)

References 59 publications

(93 reference statements)

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“…Demongeot et al showed that miR-let-7b is the most upregulated in kawasaki disease. Also, miR-129-5p may have the potential to against the S and ORF10 regions in SARS-CoV-2 infection [ 27 ].…”

Section: Mirnas Against Covid-19mentioning

confidence: 99%

The Role of miRNAs in COVID-19 Disease

et al. 2021

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Nowadays, the SARS Coronavirus 2 (SARS-CoV-2) infection is recognized as the primary cause of mortality in humans. SARS-CoV-2 is transmitted through human-to-human contact and is asymptomatic in most patients. In addition to approved vaccines against SARS-CoV-2 infection, miRNAs may also be promising options against this new virus. miRNAs are small and noncoding RNAs 18–25 nucleotides in length that target the mRNAs to degrade them or obstruct their translation miRNAs act as an observer in cells. This study reviewed the literature on the potential role of cellular miRNAs in the SARS-CoV-2-host interplay as a therapeutic option in COVID-19 patients.

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Section: Mirnas Against Covid-19mentioning

confidence: 99%

The Role of miRNAs in COVID-19 Disease

et al. 2021

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“… France To describe a potential miRNA-like action by viral RNA, at the level of oxygen transport by hemoglobin and immune response, involving the type I interferon synthesis inhibition. ( Demongeot and Seligmann, 2020 ) 15 Saini S June 2020. India To predict mature viral miRNAs and scan for target genes in the human genome.…”

Section: Resultsmentioning

confidence: 99%

“…Of similar importance, viruses can produce miRNA-like sequences or viral miRNAs that can target host genes, which can disrupt the host gene expression levels and enable the virus to create a propagation environment in the host cell ( Barbu et al, 2020 ). In this systematic review, five studies found these sequences predicted to target host immune response biological pathways, including the ones associated with the immune system, T cell-mediated immunity, response to cytokines, biological adhesion, and autophagy, as well as the regulation of signaling pathways, such as the WNT, MAPK, and TGF-beta signaling ( Demirci and Adan, 2020 , Demongeot and Seligmann, 2020 , Khan et al, 2020b , Saini et al, 2020 , Sarma et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

Marchi¹,

Sugita²,

Centa³

et al. 2021

Infection, Genetics and Evolution

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MicroRNAs are gene expression regulators, associated with several human pathologies, including the ones caused by virus infections. Although their role in infection diseases is not completely known, they can exert double functions in the infected cell, by mediating the virus infection and/or regulating the immunity-related gene targets through complex networks of virus-host cell interactions. In this systematic review, the Pubmed, EMBASE, Scopus, Lilacs, Scielo, and EBSCO databases were searched for research articles published until October 22nd, 2020 that focused on describing the role, function, and/or association of miRNAs in SARS-CoV-2 human infection and COVID-19. Following the PRISMA 2009 protocol, 29 original research articles were selected. Most of the studies reported miRNA data based on the genome sequencing of SARS-CoV-2 isolates and computational prediction analysis. The latter predicted, by at least one independent study, 1266 host miRNAs to target the viral genome. Thirteen miRNAs were identified by four independent studies to target SARS-CoV-2 specific genes, suggested to act by interfering with their cleavage and/or translation process. The studies selected also reported on viral and host miRNAs that targeted host genes, on the expression levels of miRNAs in biological specimens of COVID-19 patients, and on the impact of viral genome mutations on miRNA function. Also, miRNAs that regulate the expression levels of the ACE2 and TMPRSS2 proteins, which are critical for the virus entrance in the host cells, were reported. In conclusion, despite the limited number of studies identified, based on the search terms and eligibility criteria applied, this systematic review provides evidence on the impact of miRNAs on SARS-CoV-2 infection and COVID-19. Although most of the reported viral/host miRNAs interactions were based on in silico prediction analysis, they demonstrate the relevance of the viral/host miRNA interaction for viral activity and host responses. In addition, the identified studies highlight the potential use of miRNAs as therapeutic targets against COVID-19, and other viral human diseases (This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) database (#CRD42020199290).

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“…SARS-CoV-2 miRNAs have been shown to inhibit ribosomal translation of some key human proteins, via hybridizing their mRNAs [56]. These proteins include hemoglobin subunit beta and gamma-globin 2, IFN 1, and olfactory receptor proteins.…”

Section: Inflammation and Pathological Damagesmentioning

confidence: 99%

“…These proteins include hemoglobin subunit beta and gamma-globin 2, IFN 1, and olfactory receptor proteins. Marked perturbation of oxygen distribution in vital organs, immune response, and dysosmia in COVID-19 patients have been suggested to result from virus miRNA-like inhibition [56]. Some host miRNAs alteration, mediated by SARS-CoV-2, were strongly associated with comorbidities.…”

Section: Inflammation and Pathological Damagesmentioning

confidence: 99%

MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: biomarkers or therapeutic agents?

et al. 2020

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To date, proposed therapies and antiviral drugs have been failed to cure coronavirus disease 2019 (COVID-19) patients. However, at least two drug companies have applied for emergency use authorization with the United States Food and Drug Administration for their coronavirus vaccine candidates and several other vaccines are in various stages of development to determine safety and efficacy. Recently, some studies have shown the role of different human and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) microRNAs (miRNAs) in the pathophysiology of COVID-19. miRNAs are non-coding single-stranded RNAs, which are involved in several physiological and pathological conditions, such as cell proliferation, differentiation, and metabolism. They act as negative regulators of protein synthesis through binding to the 3′ untranslated region (3′ UTR) of the complementary target mRNA, leading to mRNA degradation or inhibition. The databases of Google Scholar, Scopus, PubMed, and Web of Science were searched for literature regarding the importance of miRNAs in the SARS-CoV-2 life cycle, pathogenesis, and genomic mutations. Furthermore, promising miRNAs as a biomarker or antiviral agent in COVID-19 therapy are reviewed.

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SARS-CoV-2 and miRNA-like inhibition power

Cited by 21 publications

References 59 publications

The Role of miRNAs in COVID-19 Disease

The Role of miRNAs in COVID-19 Disease

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: biomarkers or therapeutic agents?

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