SARS-CoV-2 and gastrointestinal diseases

Abstract

BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the novel coronavirus disease (COVID-19) pandemic, which has caused serious challenges for public health systems worldwide.Literature reviewSARS-CoV-2 invades not only the respiratory system, but also the digestive system, causing a variety of gastrointestinal diseases.SignificanceUnderstanding the gastrointestinal diseases caused by SARS-CoV-2, and the damage mechanisms of SARS-CoV-2 to the gastrointestinal tracts and gastrointestinal glands are crucial to treating the gastrointestinal diseases caused by SARS-CoV-2.ConclusionThis review summarizes the gastrointestinal diseases caused by SARS-CoV-2, including gastrointestinal inflammatory disorders, gastrointestinal ulcer diseases, gastrointestinal bleeding, and gastrointestinal thrombotic diseases, etc. Furthermore, the mechanisms of gastrointestinal injury induced by SARS-COV-2 were analyzed and summarized, and the suggestions for drug prevention and treatment were put forward for the reference of clinical workers.

Prevalence and outcomes of upper gastrointestinal bleeding in COVID‐19: A systematic review and meta‐analysis

“…It is caused by a variety of aetiologies, including peptic ulcers, variceal haemorrhage, Mallory-Weiss tears, and erosive gastritis. 3 It is a potentially fatal condition that necessitates rapid medical intervention and care.…”

“…While COVID-19's major symptoms are often respiratory, studies have shown that the virus can also affect the gastrointestinal system, causing inflammation and damage to the gastrointestinal tract. 3 This can lead to problems like gastritis, ulcers, and blood vessel erosion, which can cause UGIB. 4 It is critical that healthcare personnel are aware of this potential consequence and take it into account when examining COVID-19 patients, particularly those who present with gastrointestinal symptoms or evidence of bleeding.…”

“…Upper gastrointestinal bleeding is a clinical disorder marked by bleeding from the oesophagus, stomach, or duodenum. It is caused by a variety of aetiologies, including peptic ulcers, variceal haemorrhage, Mallory‐Weiss tears, and erosive gastritis 3 . It is a potentially fatal condition that necessitates rapid medical intervention and care.…”

“…It is a potentially fatal condition that necessitates rapid medical intervention and care. While COVID‐19's major symptoms are often respiratory, studies have shown that the virus can also affect the gastrointestinal system, causing inflammation and damage to the gastrointestinal tract 3 . This can lead to problems like gastritis, ulcers, and blood vessel erosion, which can cause UGIB 4 .…”

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

“…Individuals infected with COVID‐19 often exhibit symptoms such as cephalalgia, rhinorrhea, sneezing, pharyngitis, anosmia, and ageusia. Nevertheless, it is worth noting that a significant proportion of patients, around 80%, may have long‐term complications affecting various bodily systems, such as the neurological, 2 urogenital, 3 and digestive systems 4 diseases over the weeks or months after their recovery. The consequences of COVID‐19 exhibit a range of severity, which may be attributed to substantial variations among individuals.…”