Sarcopenic obesity in fatty liver

Merli, Manuela; Lattanzi, Barbara; Aprile, Francesca

doi:10.1097/mco.0000000000000558

Cited by 41 publications

(55 citation statements)

References 48 publications

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“…In another study on NAFLD patients [24], low S/V indicated poorer hepatic condition, con rmed with liver transient elastography. Accumulating basic and clinical researches have focused on cross-talk among muscle, fat, and liver components [26]. A recent review suggests that adipose tissue function is a critical driver of NAFLD and NASH.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

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Background: Obesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) in Chinese adults with obesity.Methods: In this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we recruited 272 obese adults aged 18–50 years with a body mass index (BMI) ≥28.0 kg/m2 and capable of using smartphones. CIMWM (n=136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n=136) provided monthly face-to-face guidance by the same panel of professionals and the same meal replacements as CIMWM group, but required subjects to complete daily self-monitoring instead of offering daily online instructions. Body composition and metabolic parameters were assessed at baseline, 1, 2, 3, and 6 months by physicians. Primary outcomes were the clinically-significant weight loss and changes in BMI and body composition.Results: Participants in both groups showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (P<0.05). CIMWM was shown to be superior to TMWM in the improvement of clinically-significant weight loss, BMI, total cholesterol (TC), the body composition parameters BFM and the skeletal muscle mass-to-visceral fat area ratio (S/V) (P<0.05). The non-alcoholic fatty liver disease score (NFS) was negatively related to S/V at baseline. After weight management, NFS was lowered among individuals with levels in the highest tertile (P<0.05). Metabolic memory in terms of the continuous reduction of BMI, BFM, and TC was retained up to 6 months in spite of participants transferring to self-monitoring assessment in the final 3 months.Conclusions: The CIMWM strategy in obese Chinese adults is proved to be more effective than TMWM in weight loss, and motivates greater adherence to intervention and lifestyle reprogramming.Trial registration: Chinese Clinical Trial Registry, ChiCTR1800017463, Registered July 31, 2018, retrospectively registry. http://www.chictr.org.cn/showproj.aspx?proj=29649

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In another study on NAFLD patients [23], low S/V indicated poorer hepatic condition, con rmed with liver transient elastography. Accumulating basic and clinical researches have focused on cross-talk among muscle, fat, and liver components [25]. A recent review suggests that adipose tissue function is a critical driver of NAFLD and NASH.…”

Section: Discussionmentioning

confidence: 99%

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Obesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) for Chinese adults with obesity. Methods In this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we included 272 obese adults aged 18–50 years with a body mass index (BMI) ≥ 28.0 kg/m2 and capable of using smartphones. CIMWM (n = 136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n = 136) provided monthly face-to-face guidance by the above-mentioned professionals and required daily self-monitoring. Measurements of body composition and metabolic parameters were assessed face-to-face at baseline, 1, 2, 3, and 6 months by physicians. Primary outcomes were the changes in BMI and body composition. Results All participants showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (P < 0.05). CIMWM was shown to be superior to TMWM in the improvement of BMI, alanine aminotransferase (ALT), and the body composition parameters BFM and VFA (P < 0.05). The relationship of baseline non-alcoholic fatty liver disease score (NFS) was positively related to the skeletal muscle mass-to-visceral fat area ratio (S/V). Additionally, the weight management program was beneficial in lowering the NFS among subjects with levels in the highest tertile (P < 0.05). Metabolic memory in terms of the continuous reduction of BMI, VFA, and ALT was retained up to 6 months in spite of participants transferring to self-monitored assessment in the final 3 months. Conclusions The CIMWM strategy in obese Chinese adults proved to be more effective than TMWM, and motivates greater adherence to intervention and lifestyle reprogramming. Trial registration: ChiCTR1800017463, Registered 31 July 2018, retrospectively registry. http://www.chictr.org.cn/showproj.aspx?proj=29649

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“…Decreased muscle mass combined with increased visceral fat mass worsens the hepatic conditions of NAFLD [119]. It was concluded that SOB is a risk factor for the development of fatty liver and may accelerate liver fibrosis in patients with fatty liver [120].…”

Section: Association Of Sob With Liver Diseasementioning

confidence: 99%

Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link

Ryu

Choi

Yang

et al. 2020

IJMS

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Sarcopenic obesity (SOB), which is closely related to being elderly as a feature of aging, is recently gaining attention because it is associated with many other age-related diseases that present as altered intercellular communication, dysregulated nutrient sensing, and mitochondrial dysfunction. Along with insulin resistance and inflammation as the core pathogenesis of SOB, autophagy has recently gained attention as a significant mechanism of muscle aging in SOB. Known as important cellular metabolic regulators, the AMP-activated protein kinase (AMPK) and the peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α) signaling pathways play an important role in autophagy, inflammation, and insulin resistance, as well as mutual communication between skeletal muscle, adipose tissue, and the liver. Furthermore, AMPK and PGC-1α signaling pathways are implicated in the gut microbiome–muscle axis. In this review, we describe the pathological link between SOB and its associated complications such as metabolic, cardiovascular, and liver disease, falls and fractures, osteoarthritis, pulmonary disease, and mental health via dysregulated autophagy controlled by AMPK and/or PGC-1α signaling pathways. Here, we propose potential treatments for SOB by modulating autophagy activity and gut dysbiosis based on plausible pathological links.

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Sarcopenic obesity in fatty liver

Cited by 41 publications

References 48 publications

Effectiveness of Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Effectiveness of Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link

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