Sarcopenia is a Negative Prognostic Factor After Curative Resection of Colorectal Cancer

Miyamoto, Yuji; Baba, Yoshifumi; Sakamoto, Yasuo; Ohuchi, Mayuko; Tokunaga, Ryuma; Kurashige, Junji; Hiyoshi, Yukiharu; Iwagami, Shiro; Yoshida, Naoya; Yoshida, Megumi; Watanabe, Masayuki; Baba, Hideo

doi:10.1245/s10434-014-4281-6

Cited by 302 publications

(244 citation statements)

References 18 publications

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“…Sarcopenia in cancer has been found to be a prognostic factor (19) that influences performance status, quality of life and compliance with combined modality therapy such as chemoradiotherapy (7,(20)(21)(22). Depletion of muscle volume aggravates the prognosis of pancreatic and hepatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of a Nutritional Index Including Muscle Volume in Stage 4 Colorectal Cancer

Nagata

Nakase

Nakamura

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Prognostic Impact of a Nutritional Index Including Muscle Volume in Stage 4 Colorectal Cancer

Nagata

Nakase

Nakamura

et al. 2016

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“…There are over twenty-five studies in the literature reporting rates of sarcopenia in different cancer populations but studies are difficult to compare due to the variety of cut-off points for sarcopenia that were used. Of these twenty-five studies, ten used the cut points according to Prado et al (38) (37) , quartiles of muscle mass (38) or optimal stratification analysis (49) . Thus, cross-comparison of rates of sarcopenia across different studies is hampered.…”

Section: Sarcopeniamentioning

confidence: 99%

Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later

et al. 2016

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An awareness of the importance of nutritional status in hospital settings began more than 40 years ago. Much has been learned since and has altered care. For the past 40 years several large studies have shown that cancer patients are amongst the most malnourished of all patient groups. Recently, the use of gold-standard methods of body composition assessment, including computed tomography, has facilitated the understanding of the true prevalence of cancer cachexia (CC). CC remains a devastating syndrome affecting 50-80 % of cancer patients and it is responsible for the death of at least 20 %. The aetiology is multifactorial and complex; driven by pro-inflammatory cytokines and specific tumour-derived factors, which initiate an energy-intensive acute phase protein response and drive the loss of skeletal muscle even in the presence of adequate food intake and insulin. The most clinically relevant phenotypic feature of CC is muscle loss (sarcopenia), as this relates to asthenia, fatigue, impaired physical function, reduced tolerance to treatments, impaired quality of life and reduced survival. Sarcopenia is present in 20-70 % depending on the tumour type. There is mounting evidence that sarcopenia increases the risk of toxicity to many chemotherapy drugs. However, identification of patients with muscle loss has become increasingly difficult as 40-60 % of cancer patients are overweight or obese, even in the setting of metastatic disease. Further challenges exist in trying to reverse CC and sarcopenia. Future clinical trials investigating dose reductions in sarcopenic patients and dose-escalating studies based on pre-treatment body composition assessment have the potential to alter cancer treatment paradigms.

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“…Recently, the influence of sarcopenia on treatment outcomes in cancer patients has been intensively investigated; sarcopenia was demonstrated to be independently associated with negative short-term [11][12][13][14][15][16][17][18] and long-term [11,[18][19][20] outcomes after surgery and an increased rate of chemotherapy-related toxicity [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy

et al. 2015

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Background Malignancy is a secondary cause of sarcopenia, which is associated with impaired cancer treatment outcomes. The aim of this study was to investigate the prevalence of preoperative sarcopenia among elderly gastric cancer patients undergoing gastrectomy and the differences in preoperative dietary intake and postoperative complications between sarcopenic and non-sarcopenic patients. Methods Ninety-nine patients over 65 years of age who underwent gastrectomy for gastric cancer were analyzed. All patients underwent gait and handgrip strength testing, and whole-body skeletal muscle mass was measured using a bioimpedance analysis technique based on the European Working Group on Sarcopenia in Older People (EWGSOP) algorithm for the evaluation of sarcopenia before surgery. Preoperative dietary intake was assessed using a food frequency questionnaire. Results Of these patients, 21 (21.2 %) were diagnosed with sarcopenia. Sarcopenic patients consumed fewer calories and less protein preoperatively (23.9 vs. 27.8 kcal/ kg ideal weight/day and 0.86 vs. 1.04 g/kg ideal weight/-day; P = 0.001 and 0.0005, respectively). Although the overall incidence of postoperative complications was similar in the two groups (57.1 % vs. 35.9 %; P = 0.08), the incidence of severe (Clavien-Dindo grade C IIIa) complications was significantly higher in the sarcopenic group than in the non-sarcopenic group (28.6 % vs. 9.0 %; P = 0.029). In the multivariate analysis, sarcopenia alone was identified as a risk factor for severe postoperative complications (odds ratio, 4.76; 95 % confidence interval, 1.03-24.30; P = 0.046). Conclusions Preoperative sarcopenia as defined by the EWGSOP algorithm is a risk factor for severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy.

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Sarcopenia is a Negative Prognostic Factor After Curative Resection of Colorectal Cancer

Abstract: Sarcopenia negatively impacts survival in patients undergoing curative resection for stage I-III CRC.

Cited by 302 publications

References 18 publications

Prognostic Impact of a Nutritional Index Including Muscle Volume in Stage 4 Colorectal Cancer

Prognostic Impact of a Nutritional Index Including Muscle Volume in Stage 4 Colorectal Cancer

Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later

Sarcopenia is associated with severe postoperative complications in elderly gastric cancer patients undergoing gastrectomy

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