Prognostic Impact of a Nutritional Index Including Muscle Volume in Stage 4 Colorectal Cancer

Expand+In Vivoiv.iiarjournals.orgIn Vivo September-October 2017 vol. 31 no. 5 1003-1009 Elevated Serum AA/EPA Ratio as a Predictor of Skeletal Muscle Depletion in Cachexic Patients with Advanced Gastro-intestinal Cancers

“…Furthermore, studies that have identified a relationship between a significant decrease in psoas muscle volume and CRP increase in patients with cancer cachexia (9). Against this background, we hypothesized that factors relating to CRP increase, such as fatty acid profile as inflammatory profiles, were associated with a decrease in psoas muscle volume (10). In addition, n-3 fatty acid enriched diets are proved to down-regulate the production of the pro-inflammatory cytokines (11), and they also reduce Th1 cytokines from monocytes and macrophages, and suppress to activate immune cells such as T-lymphocytes, NK cells, and monocytes (12)(13)(14), and finally they play important roles in inflammation-related diseases.…”

A Scoring System to Predict the Development of Bone Metastasis After Radical Resection of Colorectal Cancer

“…Prognostic factors are needed to identify patients at risk and to optimize treatment. Several factors have been suggested to have an impact on the outcome in terms of survival or locoregional recurrence such as DDR2 expression, phosphoserine phosphatase, preoperative total lesion glycolysis (TLG), nutritional status and lower body mass index (8)(9)(10)(11)(12)(13)(14). These factors can help to understand a patient's prognosis and optimize treatment allocation.…”

High Serum Essential Amino Acids as a Predictor of Skeletal Muscle Depletion in Patients With Cachexia and Advanced Gastrointestinal Cancers

“…Furthermore, studies have been conducted to identify a relationship between a significant decrease in psoas muscle volume and C‐reactive protein (CRP) increase in patients with cancer cachexia 11 . Against this background, we hypothesized that a decrease in psoas muscle volume by the increase in CRP (an inflammation index) were associated with a decrease in serum branched‐chain amino acids (BCAA) and EAA 12 …”