Sarcopenia in systemic sclerosis: the impact of nutritional, clinical, and laboratory features

Corallo, Claudio; Fioravanti, Antonella; Tenti, Sara; Pecetti, Gianluca; Nuti, Ranuccio; Giordano, Nicola Giuseppe

doi:10.1007/s00296-019-04401-w

Cited by 27 publications

(53 citation statements)

References 44 publications

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“…The prevalence was 20.7% when defining sarcopenia using the SMI [ 42 ] and 22.5% in a study from Germany, which included 91.5% females and followed the definition of EWGSOP [ 4 , 43 ]. Another study reported higher prevalence rates of 41.9 and 54.8% applying the SMI and handgrip strength criteria, respectively [ 44 ].…”

Section: Epidemiology Of Sarcopenia In Autoimmune and Rheumatic DImentioning

confidence: 99%

“…SSc is an autoimmune rheumatic disease characterized by vasculopathy, tissue fibrosis, and internal organ involvement [ 87 ]. SSc patients tend to have decreased muscle strength and endurance related to physical functional disability [ 88 ] and 20.7–54.8% of patients exhibit sarcopenia [ 42 , 43 , 44 ]. Sarcopenia in SSc has been associated with multiple organ involvements of the disease including lung, skin, esophagus, microvasculature, and urinary tracts ( Table 3 , Table S2 ) [ 42 , 44 , 87 ].…”

Section: Other Rheumatic Diseases and Sarcopeniamentioning

confidence: 99%

“…SSc patients tend to have decreased muscle strength and endurance related to physical functional disability [ 88 ] and 20.7–54.8% of patients exhibit sarcopenia [ 42 , 43 , 44 ]. Sarcopenia in SSc has been associated with multiple organ involvements of the disease including lung, skin, esophagus, microvasculature, and urinary tracts ( Table 3 , Table S2 ) [ 42 , 44 , 87 ]. Among the specific characteristics of SSc, a longer duration of disease was also associated with sarcopenia [ 42 , 44 , 89 ].…”

Section: Other Rheumatic Diseases and Sarcopeniamentioning

confidence: 99%

“…Sarcopenia in SSc has been associated with multiple organ involvements of the disease including lung, skin, esophagus, microvasculature, and urinary tracts ( Table 3 , Table S2 ) [ 42 , 44 , 87 ]. Among the specific characteristics of SSc, a longer duration of disease was also associated with sarcopenia [ 42 , 44 , 89 ]. In addition, low physical function [ 43 ], malnutrition [ 44 ], and high ESR [ 44 ] were also associated with sarcopenia similar to the findings in RA ( Table 3 ).…”

Section: Other Rheumatic Diseases and Sarcopeniamentioning

confidence: 99%

“…Among the specific characteristics of SSc, a longer duration of disease was also associated with sarcopenia [ 42 , 44 , 89 ]. In addition, low physical function [ 43 ], malnutrition [ 44 ], and high ESR [ 44 ] were also associated with sarcopenia similar to the findings in RA ( Table 3 ). In particular, elevated ESR in SSc reflected disease severity well [ 90 ].…”

Section: Other Rheumatic Diseases and Sarcopeniamentioning

confidence: 99%

See 4 more Smart Citations

Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review

Tizaoui

Terrazzino

et al. 2020

IJMS

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Sarcopenia refers to a decrease in skeletal muscle mass and function. Because sarcopenia affects mortality, and causes significant disability, the clinical importance of sarcopenia is emerging. At first, sarcopenia was recognized as an age-related disease but, recently, it has been reported to be prevalent also in younger patients with autoimmune diseases. Specifically, the association of sarcopenia and autoimmune diseases such as rheumatoid arthritis has been studied in detail. Although the pathogenesis of sarcopenia in autoimmune diseases has not been elucidated, chronic inflammation is believed to contribute to sarcopenia, and moreover the pathogenesis seems to be different depending on the respective underlying disease. The definition of sarcopenia differs among studies, which limits direct comparisons. Therefore, in this review, we cover various definitions of sarcopenia used in previous studies and highlight the prevalence of sarcopenia in diverse autoimmune diseases including rheumatoid arthritis, spondyloarthritis, systemic sclerosis, inflammatory bowel disease, and autoimmune diabetes. In addition, we cover the pathogenesis and treatment of sarcopenia in autoimmune and rheumatic diseases. This review provides a comprehensive understanding of sarcopenia in various autoimmune diseases and highlights the need for a consistent definition of sarcopenia.

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