2020
DOI: 10.3390/ijms21165678
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Abstract: Sarcopenia refers to a decrease in skeletal muscle mass and function. Because sarcopenia affects mortality, and causes significant disability, the clinical importance of sarcopenia is emerging. At first, sarcopenia was recognized as an age-related disease but, recently, it has been reported to be prevalent also in younger patients with autoimmune diseases. Specifically, the association of sarcopenia and autoimmune diseases such as rheumatoid arthritis has been studied in detail. Although the pathogenesis of sa… Show more

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Cited by 29 publications
(28 citation statements)
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References 119 publications
(243 reference statements)
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“…used a different cut-off for ASMI, since the value recommended by EWGSOP2 consensus was not able to identify low muscle mass within their sample [ 28 ]. In contrast to the study by Barbosa-Silva et al , the present study, using EWGSOP2 consensus reference values, identified a prevalence of sarcopenia similar to those reported in previous studies of SSc patients [ 13 18 ]. Therefore, instead of using the adapted cut-off values, we chose to report our findings using the reference values recommended by EWGSOP2.…”
Section: Discussionsupporting
confidence: 70%
See 1 more Smart Citation
“…used a different cut-off for ASMI, since the value recommended by EWGSOP2 consensus was not able to identify low muscle mass within their sample [ 28 ]. In contrast to the study by Barbosa-Silva et al , the present study, using EWGSOP2 consensus reference values, identified a prevalence of sarcopenia similar to those reported in previous studies of SSc patients [ 13 18 ]. Therefore, instead of using the adapted cut-off values, we chose to report our findings using the reference values recommended by EWGSOP2.…”
Section: Discussionsupporting
confidence: 70%
“…As a systemic inflammatory condition, prominently affecting patients' physical function and nutrition, SSc may be considered a major risk factor for sarcopenia [ 13 17 ]. According to different definitions, sarcopenia has been diagnosed in nearly 20% of patients with SSc [ 14 , 15 , 18 ], which is similar to other rheumatic diseases, such as psoriatic arthritis (20%), rheumatoid arthritis (20.8%), and ankylosing spondylitis (22.7%) [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…11,12 In these studies, methods such as skeletal muscle index were used in the evaluation of sarcopenia. 28 These types of measurement methods are far from evaluating the muscle groups that are affected and determining the muscles that should be included in the strengthening program. It is difficult to determine the muscles that the muscle power distribution is in favor of and against in the total muscle mass.…”
Section: Discussionmentioning
confidence: 99%
“…The adaptive mechanisms that become compromised during muscle aging are also shared with other pathological conditions, including non-alcoholic fatty liver disease (NAFLD), heart failure (HF), and autoimmune and rheumatic diseases [ 18 ], for which the identification of the mechanisms underlying sarcopenia would be valuable [ 18 , 19 , 20 , 21 , 22 ]. The accrual of ROS-induced damage to biomolecules observed in NAFLD has been associated with a progressive loss of liver function [ 18 ].…”
mentioning
confidence: 99%
“…On a similar note, chronic low-grade inflammation and the associated changes in body composition and declining physical function [ 23 , 24 , 25 ] are shared features between sarcopenia and autoimmune and rheumatic diseases [ 21 ]. In particular, the installment of a pro-inflammatory milieu mainly involving interleukin (IL) 1β, IL6, and tumor necrosis factor-α (TNF-α) has been identified in rheumatoid arthritis (RA) and indicated as a pathogenic mechanism in the disease [ 21 ]. Notably, these cytokines are also characteristic of RA patients with sarcopenia and high resting energy expenditure [ 26 , 27 ].…”
mentioning
confidence: 99%