Sarcopenia in post-menopausal women: Is there any role for vitamin D?

Anagnostis, Panagiotis; Dimopoulou, Christina; Karras, Spyridon Ν.; Lambrinoudaki, Ιrene; Goulis, Dimitrios G.

doi:10.1016/j.maturitas.2015.03.014

Cited by 61 publications

(40 citation statements)

References 73 publications

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“…Thirteen weeks of oral vitamin D supplementation and leucine-enriched whey protein improved muscle mass and lower-extremity function in older sarcopenic individuals [120]. Currently, prospective studies are underway to better define the role of vitamin D on skeletal muscles [121, 122]. …”

Section: Nutritionmentioning

confidence: 99%

Skeletal muscle aging: influence of oxidative stress and physical exercise

et al. 2017

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Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and mortality. Several factors such as reduced physical activity, hormonal changes, insulin resistance, genetic susceptibility, appetite loss, and nutritional deficiencies are involved in the physiopathology of muscle changes. Sarcopenia is characterized by structural, biochemical, molecular and functional muscle changes. An imbalance between anabolic and catabolic intracellular signaling pathways and an increase in oxidative stress both play important roles in muscle abnormalities. Currently, despite the discovery of new targets and development of new drugs, nonpharmacological therapies such as physical exercise and nutritional support are considered the basis for prevention and treatment of age-associated muscle abnormalities. There has been an increase in information on signaling pathways beneficially modulated by exercise; nonetheless, studies are needed to establish the best type, intensity, and frequency of exercise to prevent or treat age-induced skeletal muscle alterations.

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Section: Nutritionmentioning

confidence: 99%

Skeletal muscle aging: influence of oxidative stress and physical exercise

et al. 2017

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“…Various clinical studies underline the potential role of vitamin D on skeletal muscle structure and function, while vitamin deficiency appears to be associated with changes in muscle morphology (22). As an example, patients with vitamin D deficiency are suffering from osteomalacic myopathy.…”

Section: Discussionmentioning

confidence: 99%

The Relationship of Hand Grip Strength with Bone Mineral Density and Vitamin D in Postmenopausal Women

Beyazal¹,

Devrimsel²,

Turkyilmaz³

et al. 2016

Tod

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Amaç: Bu çalışmanın amacı postmenopozal kadınlarda el kavrama gücünün (EKG) kemik mineral yoğunluğu (KMY) ve D vitamin seviyeleri ile ilişkisini değerlendirmektir. Gereç ve Yöntem: Çalışmaya 131 postmenopozal kadın alındı. EKG Jamar el dinamometresi ile ölçüldü. KMY dual enerji X-ray absorbsiyometri ile lomber omurga ve femur boyun bölgelerinden ölçüldü. Serum 25-hidroksivitamin D (25OHD) seviyeleri tespit edildi. Bulgular: Hastaların yaş ortalaması 61,2±9,2 yıl idi. Ortalama EKG 22,9 kg idi ve 32 hasta (%24,4) düşük EKG'ye sahipti. Otuz yedi hasta (%28,2) osteoporotik, 62 hasta (%47,3) osteopenikti. Ortalama 25OHD düzeyi 17 ng/mL idi ve 101 hasta (%77,1) D vitamin yetersizliğine sahipti. Osteoporoz, osteopeni ve normal KMY'ye sahip gruplar arasında EKG bakımından anlamlı farklılık vardı (p=0,016). EKG değerleri lomber omurga ve femur boyun kısımlarındaki T skorları ve KMY değerleri ile pozitif korelasyon (p<0,001, r=0,340; p<0,001, r=0,300; p<0,001, r=0,320; p=0,001, r=0,298 sırasıyla), yaş ve menopoz süresi ile negatif korelasyon (p<0,001, r=-0,344; p<0,001, r=-0,318 sırasıyla) gösterdi. Ancak, EKG ve 25OHD seviyeleri arasında herhangi bir ilişki bulunmadı (p=0,860; r=0,016). Sonuç: Osteoporoz tanısı olan postmenopozal kadınlar, normal KMY'ye sahip postmenopozal kadınlardan daha düşük EKG'ye sahiptir ve EKG bu toplumda KMY ile ilişkili iken, D vitamin ile ilişkili değildir. Postmenopozal kadınlardaki osteoporoz risk yönetiminde hastalar kas gücünün artırılması yönünde teşvik edilmelidirler. Anahtar kelimeler: Kas gücü, el kavrama gücü, kemik mineral yoğunluğu, D vitamin Objective: The aim of the present study was to evaluate the relationship of hand grip strength (HGS) with bone mineral density (BMD) and vitamin D levels in postmenopausal women. Materials and Methods: One hundred thirty one postmenopausal women were included in this study. HGS was measured by Jamar hand dynamometer. BMD was measured by dual energy X-ray absorptiometry at lumbar spine and femoral neck sites. Serum 25-hydroxyvitamin D (25OHD) levels were measured. Results: The mean age of patients was 61.2±9.2 years. The mean HGS was 22.9 kg and 32 patients (24.4%) had low HGS. Thirty seven patients (28.2%) were osteoporotic and 62 (47.3%) were osteopenic. The mean 25OHD level was 17 ng/mL and 101 (77.1%) patients having vitamin D insufficiency. There was a significant difference in HGS values among groups with osteoporosis, osteopenia, and normal BMD (p=0.016). HGS values demonstrated a positive correlation with T-scores and BMD values at lumbar spine and femoral neck sites (p<0. 001, r=0.340; p<0.001, r=0.300; p<0.001, r=0.320; p=0.001, r=0.298, respectively) and negative correlation with age and duration of menopause (p<0.001, r=-0.344; p<0.001, r=-0.318; respectively). However, no significant association was observed between 25OHD levels and HGS (p=0.860, r=0.016). Conclusion: Postmenopausal women with osteoporosis had lower HGS than postmenopausal women with normal BMD, and HGS was significantly correlated with BMD, but not with vitamin D ...

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“…One study found that children with haemophilia had decreased muscle area in the forearm, as compared with their age‐specific reference values . Although the term ‘sarcopenia’ was used without a strict definition, this study is of outmost importance because if it is confirmed in adult studies, it may further elucidate the spectrum of fracture risk in PWH .…”

Section: Introductionmentioning

confidence: 86%