Sarcopenia in patients with chronic kidney disease: prevalence, pathogenesis and clinical significance

Гасанов, М. З.

doi:10.36485/1561-6274-2021-25-1-47-58

Cited by 4 publications

(2 citation statements)

References 74 publications

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“…Концепция саркопении активно изучается при ХНИЗ [1565][1566][1567]. Прогрессирующая потеря мышечной массы и сопутствующее снижение мышечной силы связаны с рядом ХНИЗ, особенно сопровождающихся ХСН [1568], СД2 [1563,[1569][1570][1571], нейродегенеративными заболеваниями (болезнь Альцгеймера, Паркинсона и др. ), различные виды онкологической патологии.…”

Section: наиболее частые варианты коморбидности у пациентов пожилого ...unclassified

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

Drapkina,

Kontsevaya,

Kalinina

et al. 2024

Cardiovasc Ther Prev

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Section: наиболее частые варианты коморбидности у пациентов пожилого ...unclassified

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

Drapkina,

Kontsevaya,

Kalinina

et al. 2024

Cardiovasc Ther Prev

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“…В условиях нарушения фильтрационной способности почек, его концентрация в крови увеличивается. Вместе с тем ИС играет важную роль в прогрессировании ССР, особенно в группе диализных больных, так как полностью не проникает через диализную мембрану и, накапливаясь в организме, вызывает развитие осложнений [10,11]. Широкий спектр таких биологических эффектов ИС, как потенцирование системного воспаления, активация воспалительного ответа и оксидативного стресса, кальцификация сосудистой стенки, влияние на адипоциты и иммунные клетки, стимуляция пролиферации эндотелиальных клеток, может приводить к эндотелиальной дисфункции и прогрессированию ССР [12][13][14][15].…”

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The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

Гасанов

Kolomyitseva

Батюшин

2021

Arhivʺ vnutrennej mediciny

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In recent decades, the prevalence of chronic kidney disease (CKD) in the population has a clear upward trend. This is due, first of all, to an increase in the frequency of occurrence of the main factors leading to its development: diabetes mellitus and arterial hypertension. The progression of CKD against the background of the action of these factors leads to a steady loss of the kidneys of their filtration capacity and the development of complications associated with this process. These include, first of all, metabolic and acid-base disorders, electrolyte abnormalities, uremic intoxication, overhydration, protein-energy wasting, sarcopenia and others. Most of them are involved in the development of endothelial dysfunction and the formation of cardiovascular remodeling (CVR), as a key component of the cardiorenal continuum. At the same time, there is a mutual negative influence of pathology of the cardiovascular system on renal function and manifestations of CKD on cardiovascular hemodynamics. This “vicious circle” leads to the development of end-stage renal disease and an increase in cardiovascular risk and mortality from diseases of the circulatory system in patients with advanced stages of CKD. In this connection, this work is devoted to the study of the role of uremic intoxication and, in particular, indoxyl sulfate, in the development of CVR in patients with CKD at different stages of the disease.

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The role of genes and myokines of developing sarcopenia: A review

Valeeva,

Rodygina,

Yilmaz

2024

Consilium Medicum

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Sarcopenia is associated with progressive generalized skeletal muscle weakness, persistent decline in muscle strength, function, and quality of life in the elderly population. The presence of sarcopenia worsens the prognosis of older patients. In this regard, the study of the etiology and pathogenesis of sarcopenia, the identification of early markers for the diagnosis of this disease are relevant areas today. Myokines are secreted by skeletal muscle and play a important role in the regulation of muscle mass and function, metabolic homeostasis. Myokine synthesis disruption may contribute to the development of sarcopenia. In addition, we can see the polymorphism association of various genes with the development of the disease. This review brings together current knowledge about myokines and genetic factors as potential biomarkers for the early diagnosis of sarcopenia.

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Sarcopenia in patients with chronic kidney disease: prevalence, pathogenesis and clinical significance

Cited by 4 publications

References 74 publications

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines

The Role of Uremic Intoxication in the Development of Cardiovascular Remodeling in Patients with Chronic Kidney Disease Stages 3a-5d

The role of genes and myokines of developing sarcopenia: A review

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