Sarcopenia in Liver Disease: Current Evidence and Issues to Be sResolved

Song, Meiyi; Xia, Lu; Liu, Qi; Sun, Manyi; Wang, Fei; Chen, Yang

doi:10.1007/978-981-13-1435-3_19

Cited by 3 publications

(2 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protein concentration is decreased because of impaired hepatic activity and the lymphocyte count is lower because of hypersplenism. Thus, determination of the serum protein level, measurement of prothrombin time, or erythrocyte, lymphocyte or platelet counts are also not useful to assess malnutrition [ 6 ].…”

Section: Assessment Of Nutritional Statusmentioning

confidence: 99%

Nutrition and Chronic Liver Disease

Fuente

2022

Clin Drug Investig

View full text Add to dashboard Cite

Malnutrition is common in chronic liver diseases and worsens the patient’s prognosis. Many liver disorders are associated with nutritional deficiencies. Some of the main factors that can lead to malnutrition in patients with chronic liver disease include decreased lipid absorption and reduced albumin production. In addition, these patients are sometimes candidates for a liver transplant that requires nutritional intervention after surgery to improve their prognosis. Thus, it is very important to recognise malnutrition in patients with liver failure in order to resolve it, mainly by a complete history of the patient, dietary survey, determination of muscle mass and a subjective assessment. To ensure a good nutritional status, exercise and lifestyle changes are considered, including dietary modifications, especially with a Mediterranean pattern. This article reviews these topics, including dietary modifications before and after liver transplantation. Additionally, nutritional recommendations are offered to patients with metabolic hepatic steatosis.

show abstract

Section: Assessment Of Nutritional Statusmentioning

confidence: 99%

Nutrition and Chronic Liver Disease

Fuente

2022

Clin Drug Investig

View full text Add to dashboard Cite

show abstract

“…Latest studies have shown that sarcopenia and NAFLD show similar pathophysiological profiles and must be studied in combination in elderly people [ 106 ]. In fact, age-related sarcopenia has been recently considered a risk factor for NAFLD and targeting sarcopenia can benefit NAFLD progression [ 107 ] probably by reducing hepatic fat.…”

Section: Liver and Skeletal Muscle Are Linked In Nafldmentioning

confidence: 99%

Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD)

2020

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years. Diet and exercise interventions are the first-line treatment options, with weight loss via a hypocaloric diet being the most important therapeutic target in NAFLD. However, most NAFLD patients are not able to achieve such weight loss. Therefore, the requisite is the investigation of other effective therapeutic approaches. This review summarizes research on understanding complex pathophysiology underlying dietary approaches and exercise interventions with the potential to prevent and treat NAFLD.

show abstract

Body Protein Sparing in Hibernators: A Source for Biomedical Innovation

et al. 2021

View full text Add to dashboard Cite

Proteins are not only the major structural components of living cells but also ensure essential physiological functions within the organism. Any change in protein abundance and/or structure is at risk for the proper body functioning and/or survival of organisms. Death following starvation is attributed to a loss of about half of total body proteins, and body protein loss induced by muscle disuse is responsible for major metabolic disorders in immobilized patients, and sedentary or elderly people. Basic knowledge of the molecular and cellular mechanisms that control proteostasis is continuously growing. Yet, finding and developing efficient treatments to limit body/muscle protein loss in humans remain a medical challenge, physical exercise and nutritional programs managing to only partially compensate for it. This is notably a major challenge for the treatment of obesity, where therapies should promote fat loss while preserving body proteins. In this context, hibernating species preserve their lean body mass, including muscles, despite total physical inactivity and low energy consumption during torpor, a state of drastic reduction in metabolic rate associated with a more or less pronounced hypothermia. The present review introduces metabolic, physiological, and behavioral adaptations, e.g., energetics, body temperature, and nutrition, of the torpor or hibernation phenotype from small to large mammals. Hibernating strategies could be linked to allometry aspects, the need for periodic rewarming from torpor, and/or the ability of animals to fast for more or less time, thus determining the capacity of individuals to save proteins. Both fat- and food-storing hibernators rely mostly on their body fat reserves during the torpid state, while minimizing body protein utilization. A number of them may also replenish lost proteins during arousals by consuming food. The review takes stock of the physiological, molecular, and cellular mechanisms that promote body protein and muscle sparing during the inactive state of hibernation. Finally, the review outlines how the detailed understanding of these mechanisms at play in various hibernators is expected to provide innovative solutions to fight human muscle atrophy, to better help the management of obese patients, or to improve the ex vivo preservation of organs.

show abstract

Sarcopenia in Liver Disease: Current Evidence and Issues to Be sResolved

Cited by 3 publications

References 129 publications

Nutrition and Chronic Liver Disease

Nutrition and Chronic Liver Disease

Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD)

Body Protein Sparing in Hibernators: A Source for Biomedical Innovation

Contact Info

Product

Resources

About