Sarcopenia, dynapenia, and body composition in Parkinson’s disease: are they good predictors of disability?: a case–control study

Özer, Firüzan Fırat; Akın, Sibel; Gültekın, Murat; Zararsız, Gözde Ertürk

doi:10.1007/s10072-019-04073-1

Cited by 19 publications

(22 citation statements)

References 25 publications

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“…However, some other studies believed that sarcopenia had no correlations with disease duration (14), HY (14), UPDRS-I (14), UPDRS-II (14), depression (15,17), and cognition (14,15). In addition, some studies found that falls incidence (15,16) and female proportion (20) in PD with sarcopenia were higher than those in PD without sarcopenia. However, some studies reported that there were no differences in falls incidence (20) and female proportion (14,15) between PD patients with and without sarcopenia.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, some studies found that falls incidence (15,16) and female proportion (20) in PD with sarcopenia were higher than those in PD without sarcopenia. However, some studies reported that there were no differences in falls incidence (20) and female proportion (14,15) between PD patients with and without sarcopenia. Therefore, the main objective of the current study was acted in accordance with PICOS through systematical review and meta-analysis method: participants (P): patients with a diagnosis of PD from medical institutions or population; intervention (I): PD patients with sarcopenia; control (C): PD patients without sarcopenia; outcome (O): the prevalence of sarcopenia in PD patients, and the differences in clinical features between PD patients with and without sarcopenia; and study design (S): cohort study, case-control study, or cross-sectional study.…”

Section: Introductionmentioning

confidence: 99%

“…Sarcopenia can be assessed by the EWGSOP algorithm including the combination of a low muscle mass and a low handgrip strength (HS) or a low gait speed (GS). Muscle mass is measured by using traditional anthropometric measuresbioelectrical impedance analysis (BIA) (3,4,17,19,20), whereas several studies used more precise methods, such as dualenergy X-ray absorptiometry (DEXA) (14,21,22) and magnetic resonance imaging (MRI) (23). The prevalence of sarcopenia in community-dwelling older adults was reported in the wide range of 1-50% (24).…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of sarcopenia in community-dwelling older adults was reported in the wide range of 1-50% (24). The prevalence of sarcopenia in PD was higher than that of the healthy older control group matched for age and sex (3,20,21). However, the prevalence of sarcopenia in PD is varied among different studies.…”

Section: Introductionmentioning

confidence: 99%

“…However, the prevalence of sarcopenia in PD is varied among different studies. For example, some studies reported the prevalence of sarcopenia in PD with a range of 6-31.4% (3,4,19,20,22) according to the 1st version EWGSOP; other studies found the prevalence of sarcopenia as 40.4, 17.2, 58, 47.2, and 38% according to the decreased ASMMI (14), AWGS (21), SARC-F (15), probable sarcopenia (16), and ESS (17), respectively. This large discrepancy among the studies may be due to diagnostic criteria, muscle mass measurement techniques, different cut-off values for muscle mass indexes for the definition of sarcopenia, and as well as the characteristic of enrolled PD patients.…”

Section: Introductionmentioning

confidence: 99%

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Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis

et al. 2021

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Background: Parkinson's disease (PD) and sarcopenia are two common diseases in aging people. To date, the prevalence of sarcopenia in PD patients and the relationship between clinical features and sarcopenia in PD patients are not clear. The aim of the study was to (1) assess the prevalence of sarcopenia in PD patients and (2) reveal the clinical features between PD patients with and without sarcopenia.Method: A systematic review was carried out through screening PubMed, EMBASE, and Cochrane database in May 2020. All study designs (case–control, cohort, and cross-sectional studies) were eligible for meta-analysis. Data of patients' characteristics, sarcopenia criteria, sarcopenia prevalence, and sarcopenia measures were retrieved. The primary outcome was estimated prevalence of sarcopenia by a pooled prevalence (%) and its 95% confidence interval (CI), using a random-effects model. The secondary outcome was the differences in clinical features between PD patients with and without sarcopenia by meta-analysis. Included articles were assessed for risk of bias. Potential sources of variation were investigated by using subgroup analyses and meta-regression.Result: Ten studies were included in the review. Among them, nine were cross-sectional studies, and one was a prospective cohort study. Age of participants with PD in the studies ranged from 51.1 to 80.7 years. The estimated prevalence of sarcopenia ranged from 6 to 55.5%. The random-effects pooled prevalence was 29% (95% CIs: 0.18–0.40). When only studies at low risk of bias were considered, pooled prevalence decreased to 17% (95% CIs: 0.02–0.33), with still high heterogeneity. The incidence of falls in PD patients with sarcopenia was higher than that in PD patients without sarcopenia. There was no difference in sex ratio between PD patients with and without sarcopenia.Conclusion: Sarcopenia seems to be common in patients with PD. Early assessment of sarcopenia should be implemented in PD to avoid fall and disability.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis

et al. 2021

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The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

Rivadeneyra

Verhagen

Bartulos

et al. 2021

Movement Disord Clin Pract

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Background Skeletal muscle loss has been associated with declining physical performance and a negative prognostic effect on falls, disability, and mortality risk in Parkinson's disease. Objectives We aimed to analyze the clinical correlates associated with skeletal muscle wasting in Parkinson's disease. Methods This was a cross‐sectional, case–control, observational study. We collected information on dietary intake with a 24‐hour recall questionnaire, body composition with bioelectrical impedance, motor severity with the Unified Parkinson's disease Rating Scale, and physical activity with the Global Physical Activity Questionnaire. We used multivariate linear regression analysis to analyze the sociodemographic and clinical correlates associated with skeletal muscle loss after adjusting for confounding variables. Results Forty‐three patients with Parkinson's disease and 21 matched family members were included. Patients and family members had similar body composition, anthropometrics, and nutritional parameters. Advanced patients had similar nutrient intakes compared to patients with mild‐to‐moderate Parkinson's disease. In the multivariate linear regression analysis, female patients with low physical activity and low energy intake were more likely to have skeletal muscle loss. Conclusions Skeletal muscle wasting is a complex multifactorial problem. Dietary strategies and physical exercise should be recommended, especially to females with Parkinson's disease, to prevent significant skeletal muscle wasting.

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Determinant factors of sarcopenia in individuals with Parkinson’s disease

et al. 2020

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Sarcopenia, dynapenia, and body composition in Parkinson’s disease: are they good predictors of disability?: a case–control study

Cited by 19 publications

References 25 publications

Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis

Sarcopenia in Patients With Parkinson's Disease: A Systematic Review and Meta-Analysis

The Impact of Dietary Intake and Physical Activity on Body Composition in Parkinson's Disease

Determinant factors of sarcopenia in individuals with Parkinson’s disease

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