Determinant factors of sarcopenia in individuals with Parkinson’s disease

Luz, Marcella Campos Lima da; Bezerra, Gleyce Kelly de Araújo; Asano, Amdore Guescel; Lemos, Manoel; Cabral, Poliana Coelho

doi:10.1007/s10072-020-04601-4

Cited by 11 publications

(8 citation statements)

References 34 publications

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“…Several more recent studies have reported higher rates. A Turkish case–control study ( n = 155) used EWGSOP-1 and reported a prevalence of 50 % in PD and 31 % in controls (145) , whereas a Brazilian study reported a prevalence of 22 % in PD using EWGSOP-2 compared to 55 % with EWGSOP-1 (146) . A recent Malaysian study reported a prevalence of 26 % in PD using EWGSOP-2 and 4 % in controls (147) , greater than previous Malaysian rates based on The Asian Working Group on Sarcopenia criteria (148) .…”

Section: Whole Body Metabolism In Parkinson's Diseasementioning

confidence: 99%

Parkinson's disease: the nutrition perspective

et al. 2021

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Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and affects about 1% of the population over the age of 60 years in industrialised countries. The aim of this review is to examine nutrition in PD across three domains: dietary intake and the development of PD; whole body metabolism in PD and the effects of PD symptoms and treatment on nutritional status. In most cases, PD is believed to be caused by a combination of genetic and environmental factors and although there has been much research in the area, evidence suggests that poor dietary intake is not a risk factor for the development of PD. The evidence about body weight changes in both the prodromal and symptomatic phases of PD is inconclusive and is confounded by many factors. Malnutrition in PD has been documented as has sarcopaenia, although the prevalence of the latter remains uncertain due to a lack of consensus in the definition of sarcopaenia. PD symptoms, including those which are gastrointestinal and non-gastrointestinal, are known to adversely affect nutritional status. Similarly, PD treatments can cause nausea, vomiting and constipation, all of which can adversely affect nutritional status. Given that the prevalence of PD will increase as the population ages, it is important to understand the interplay between PD, comorbidities and nutritional status. Further research may contribute to the development of interventional strategies to improve symptoms, augment care and importantly, enhance the quality of life for patients living with this complex neurodegenerative disease.

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Section: Whole Body Metabolism In Parkinson's Diseasementioning

confidence: 99%

Parkinson's disease: the nutrition perspective

et al. 2021

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“…We took into consideration 49 studies [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ] in which BMI was assessed, resulting in 5727 patients, 57.3% of whom were men and 40.9% of whom were women. The lowest reported mean BMI was 17.84 kg/m 2 [ ...…”

Section: Resultsmentioning

confidence: 99%

“…Many authors opted not to provide information on the exact number of patients at risk of malnutrition or malnourished, only the mean score of the questionnaire for the entire cohort studied [ 13 , 14 , 17 , 19 , 20 , 23 , 24 , 25 , 26 , 27 , 28 , 35 , 37 , 44 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Malnutrition in Patients with Parkinson’s Disease: A Systematic Review

et al. 2022

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Objectives: This systematic review analyzed the prevalence of malnutrition in patients with Parkinson’s Disease. Study design: a systematic review. Method: Four databases—Cochrane, PubMed, Embase and Web of Science—were searched from October 2021 to June 2022 by two independent researchers. The inclusion criteria were as follows: patients above 18 years old with confirmed Parkinson’s Disease, performed screening nutritional assessment, cohort studies, case-control studies, and cross-sectional studies. Patients without Parkinson’s Disease and with other parkinsonian syndromes were excluded. Results: 49 studies were included in this systematic review. Patients ranged in age from 20 to 96 years. There were 5613 subjects included. According to Mini Nutritional Assessment, 23.9% (n = 634) participants were at risk of malnutrition and 11.1% (n = 294) were malnourished. According to BMI score, most patients were either obese or overweight. Conclusions: the prevalence of malnutrition or risk of malnutrition in the study group was significant. Therefore, more specific and detailed studies on the prevalence of malnutrition in patients with Parkinson’s Disease are needed.

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“…The individuals with both PD and sarcopenia had greater difficulty performing activities of daily living, such as brushing their teeth, taking a shower, and getting up from bed 15 . In addition, a higher risk of falls is associated with people with PD and sarcopenia 9 .…”

Section: Introductionmentioning

confidence: 99%

Gait velocity and stability are correlated to muscle and bone mass loss in people with Parkinson’s disease: a preliminary study

Barbieri¹,

Faria

Similei

et al. 2022

BJMB

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Background: Parkinson’s disease (PD) exacerbates muscle and bone mass loss, which is associated with several negative outcomes such as falls and disability. Thus, muscle and bone mass loss may be one mechanism for the mediator role between gait impairments and PD. Aim: To verify the relationship between the spatial-temporal gait parameters and the body composition of the lower limbs in people with PD. Method: Thirteen people with PD were evaluated on two different days: i) clinical and gait evaluation; ii) body composition evaluation. The step length, width, duration and speed, the percentage in double support, and gait velocity during walking at self-selected velocity. Dual-energy X-ray absorptiometry technique was used to measure fat mass, lean mass, bone mass, and the total mass, for whole body, and separately for each limb. Pearson’s correlation coefficients were applied between the spatial-temporal gait parameters and the variables of body composition of lower limbs. Results: Reduced lean and bone mass of both legs were related to faster gait velocity (r=0.6, p<0.03 and r=0.7, p<0.01, respectively) and step speed (r=0.5, p<0.05 and r=0.65, p<0.02, respectively). Also, narrower step width was related to the higher bone mass of both legs (r=0.6, p<0.03). However, muscle and bone mass did not correlate with step length and duration, and percentage of double support. Interpretation:Our findings suggest that the muscle and bone mass of the lower limbs are important body characteristics for gait impairments in people with PD and should be monitored over the disease.

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Determinant factors of sarcopenia in individuals with Parkinson’s disease

Cited by 11 publications

References 34 publications

Parkinson's disease: the nutrition perspective

Parkinson's disease: the nutrition perspective

Prevalence of Malnutrition in Patients with Parkinson’s Disease: A Systematic Review

Gait velocity and stability are correlated to muscle and bone mass loss in people with Parkinson’s disease: a preliminary study

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