SARcopenia Assessment in Hypertension

Abstract

Objectives:The aims of the study were to investigate the relationship between sarcopenia and renin-angiotensin system-related disorders and to explore the effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on muscle mass/function and physical performance. Design: This multicenter, cross-sectional study was performed using ISarcoPRM algorithm for the diagnosis of sarcopenia. Results: Of the 2613 participants (mean age = 61.0 ± 9.5 yrs), 1775 (67.9%) were hypertensive. All sarcopenia-related parameters (except chair stand test in males) were worse in hypertensive group than in normotensive group (all P < 0.05). When clinical/potential confounders were adjusted, hypertension was found to be an independent predictor of sarcopenia in males (odds ratio = 2.403 [95% confidence interval = 1.514-3.813]) and females (odds ratio = 1.906 [95% confidence interval = 1.328-2.734], both P < 0.001). After adjusting for confounding factors, we found that all sarcopenia-related parameters (except grip strength and chair stand test in males) were independently/negatively related to hypertension (all P < 0.05). In females, angiotensin-converting enzyme inhibitors users had higher grip strength and chair stand test performance values but had lower anterior thigh muscle thickness and gait speed values, as compared with those using angiotensin II receptor blockers (all P < 0.05). Conclusions: Hypertension was associated with increased risk of sarcopenia at least 2 times. Among antihypertensives, while angiotensinconverting enzyme inhibitors had higher muscle function values, angiotensin II receptor blockers had higher muscle mass and physical performance values only in females.

The Paradoxical Impact of Diabetes Mellitus on Osteoporosis and Sarcopenia: The ParaDOS Study

“…Other than older age, and increased weight and duration of DM had positive and independent impact concerning the presence of sarcopenia. Recently, it has been shown that the presence of DM was negatively related with handgrip strength values [17]. Moreover, a longitudinal study has also reported that chronic conditions such as cardiovascular disease, hypertension and DM were associated with a rapid decline of handgrip strength [31].…”

“…Likewise, poor walking speed and CST performance were shown to be related with higher risk of falls and fractures [37]. The CST evaluates muscle power and strength, and balance and endurance of the lower extremity muscles, which are closely associated with power required daily life activities such as speed walking, standing from a chair and climbing stairs [4,17].…”

“…CST and gait speed) were used for the analyses. The ISarcoPRM algorithm was used for the diagnosis of sarcopenia [4,17].…”

“…On the other hand, it is well known that prompt detection of age-related muscle loss can be done by measurement of the quadriceps (i.e. anterior midthigh) muscle [4,17].…”

The Association of Low Skeletal Muscle Mass with Complex Distal Radius Fracture

“…In our study, DRF patients had the characteristics of CVD. A multicenter cross-sectional study reported that hypertension was associated with an increased risk of sarcopenia at least twice [ 33 ]. Moreover, sarcopenia has been reported to be significantly associated with metabolic syndrome (OR 3.073, CI 2.009–4.701, p < 0.001) [ 34 ].…”