The relationship between sarcopenia-related measurements and osteoporosis: The SARCOP study

Tiftik, Tülay; Kara, Murat; Koyuncu, Esra Gizem; Kaymak, Bayram; Çelik, Ömer Faruk; Çiftçi, İrem; Korkmaz, Gizem Olgu; Analay, Pelin; Aksakal, Mahmud Fazıl; Ocak, Hasan; Mülkoğlu, Cevriye; Genç, Hakan; Akıncı, Ayşen; Özçakar, Levent

doi:10.1007/s00198-022-06563-z

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…Studies have found that low grip strength was independently associated with BMD in lumbar spine and hip [52,53]. A study including 546 postmenopausal women reported that among sarcopenia-related parameters, having low grip strength (i.e., probable sarcopenia) was independently associated with the presence of OP [19]. We also found that probable sarcopenia was independently related with about 1.4 times higher SSP tears in postmenopausal women.…”

Section: Discussionsupporting

confidence: 55%

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The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study

Kara,

Durmuş

et al. 2024

Calcif Tissue Int

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We aimed to investigate the relationship among probable sarcopenia, osteoporosis (OP) and supraspinatus tendon (SSP) tears in postmenopausal women. Postmenopausal women screened/followed for OP were recruited. Demographic data, comorbidities, exercise/smoking status, and handgrip strength values were recorded. Probable sarcopenia was diagnosed as handgrip strength values < 20 kg. Achilles and SSP thicknesses were measured using ultrasound. Among 1443 postmenopausal women, 268 (18.6%) subjects had SSP tears. Unilateral tears were on the dominant side in 146 (10.1%) and on the non-dominant side in 55 women (3.8%). In contrast to those without, women with SSP tears had older age, lower level of education, thinner SSP and lower grip strength (all p < 0.05). In addition, they had higher frequencies of hypertension, hyperlipidemia, DM, OP and probable sarcopenia, but lower exercise frequency (all p < 0.05). Binary logistic regression modeling revealed that age [odds ratio (OR): 1.046 (1.024–1.067 95% CI)], hypertension [OR: 1.560 (1.145–2.124 95% CI)], OP [OR: 1.371 (1.022–1.839 95% CI)] and probable sarcopenia [OR: 1.386 (1.031–1.861 95% CI)] were significant predictors for SSP tears (all p < 0.05). This study showed that age, presence of hypertension, probable sarcopenia and OP were related with SSP tears in postmenopausal women. To this end, although OP appeared to be related to SSP tears, SSP tear/thickness evaluation can be recommended for OP patients, especially those who have other risk factors such as older age, higher BMI, hypertension, and probable sarcopenia.

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Section: Discussionsupporting

confidence: 55%

“…While calculating the mean L1-L4 BMD T-scores, abnormal scores (i.e. more than 1.0 SD difference between T-scores of consecutive vertebrae) were excluded, and the mean T-score value of the other vertebrae (three or at least two) was considered for the diagnosis of OP [19].…”

Section: Osteoporosis Evaluationmentioning

confidence: 99%

The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study

Kara,

Durmuş

et al. 2024

Calcif Tissue Int

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“…Osteoporosis (OP) can develop with aging, especially after menopause. The pertinent risk factors include -but not con ned to -older age, low body weight, physical inactivity, and smoking [32]. On the other hand, while overweight and obesity are positively correlated with BMD (i.e.…”

Section: Discussionmentioning

confidence: 99%

The Paradoxical Impact of Diabetes Mellitus on Osteoporosis and Sarcopenia: The ParaDOS Study

Tiftik,

Kara,

Mülkoğlu

et al. 2023

Preprint

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Purpose Type 2 diabetes mellitus (T2DM), osteoporosis (OP) and sarcopenia are major public health problems related with higher fall/fracture risks, morbidity and mortality. Due to the lack of a comprehensive analysis among T2DM, OP and sarcopenia; we aimed to explore the impact of T2DM on OP and sarcopenia in postmenopausal women. Methods This cross-sectional study included postmenopausal women who admitted to the departments of physical & rehabilitation medicine, and endocrinology and metabolism. Demographic data, nutrition/cognition status and frailty scores were recorded. Sarcopenia-related parameters including SARC-F, anterior thigh muscle thickness, handgrip strength, chair stand test, gait speed, and one-leg stand test for balance were measured. ISarcoPRM algorithm was used for the diagnosis of sarcopenia. Results A total of 444 postmenopausal women were consecutively enrolled. T2DM patients (N = 158, 35.6%) had higher frequency of sarcopenia, but lower frequency of OP than controls (both p < 0.05). As regards regression analyses; T2DM - either under the treatment of oral antidiabetic drugs or insulin - had a negative association with presence of OP (about 2 to 3 times lower, respectively). The duration of T2DM had a positive association with sarcopenia and a negative association with balance (all p < 0.05). Conclusion T2DM has paradoxical effects on bone, muscle and balance. Although insulin treatment might have anabolic effects on bone (protecting OP), the disease (duration) itself has negative effects on sarcopenia/balance.

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“…Furthermore, few studies investigating these relationships have considered the three components of sarcopenia as determined by the EWGSOP2, and the ndings are contradictory. Tiftik et al reported that low grip strength was associated with a 1.6-fold greater risk of osteoporosis according to the WHO criteria (7). Kirk et al showed an association only between hip BMD and gait speed when evaluating all three components of sarcopenia (8).…”

Section: Introductionmentioning

confidence: 99%

“…There is con icting evidence in the literature regarding the relationships between sarcopenia, its components, and osteoporosis (7,8,9). Furthermore, few studies investigating these relationships have considered the three components of sarcopenia as determined by the EWGSOP2, and the ndings are contradictory.…”

Section: Introductionmentioning

confidence: 99%

Association between sarcopenia, its components, and osteoporosis in the FRISBEE cohort.

Tchang,

De Filette,

Iconaru

et al. 2024

Preprint

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objective Bone and muscle diseases are both highly prevalent in aging adults but results from previous studies examining the relationship between sarcopenia and its components with osteoporosis are inconsistent. This study aimed to evaluate the association between sarcopenia and its components with osteoporosis in elderly postmenopausal women. Materials & Methods This study is based on cross-sectional data from the Fracture RISk Brussels Epidemiological Enquiry (FRISBEE), involving 3560 community-dwelling post-menopausal women initially included between 2007 and 2013. Randomly selected subjects were reassessed 10 years after inclusion with an evaluation of body composition by dual X-ray absorptiometry (DXA), with a medical questionnaire and a complete geriatric assessment. The diagnostic criteria for sarcopenia were low muscle mass < 5.5 kg/m2, low muscle strength < 16 kg, and low gait speed < 0.8 m/s according to the European Working Group on Sarcopenia in Older People (EWGSOP2). Osteoporosis was defined by the National Bone Health Alliance Working Group proposed extended criteria including a history of major osteoporotic fracture and high fracture risk. Results Among the 500 women included, with a median age of 77.4 (74.7–81.8) years, 178 (35.6%) were osteoporotic. Significant correlations were shown between sarcopenia components and bone mineral density (BMD) at all sites as well as trabecular bone score (TBS). The strongest correlations were between handgrip strength and distal forearm BMD (r = 0.27; p < 0.001), and between appendicular lean mass index (ALMI) and total hip BMD (r = 0.36; p < 0.001). Significant differences were observed between sub-groups of osteoporotic status: the handgrip strength, short physical performance battery (SPPB) test, gait speed, and ALMI were significantly lower in osteoporotic subjects (p < 0.001). After adjustment for all covariates, handgrip strength and gait speed were still significantly associated with osteoporosis with an odds ratio of 0.92 (0.88–0.97) and 0.33 (0.11–0.96), respectively. Handgrip strength under 16 kg showed a 2.2-fold higher risk of osteoporosis after adjustment for all covariates. Conclusion Sarcopenia, as defined by EWGSOP2, and its components, particularly handgrip strength and gait speed, were significantly associated with osteoporosis. The trabecular bone score, a surrogate for bone microarchitecture, was also significantly associated with all sarcopenia components. Therefore, it should be taken into consideration when evaluating bone health and fracture risk in routine geriatric clinical practice.

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The relationship between sarcopenia-related measurements and osteoporosis: The SARCOP study

Cited by 7 publications

References 33 publications

The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study

The Relationship Among Probable SARCopenia, Osteoporosis and SuprasPinatus Tendon Tears in Postmenopausal Women: The SARCOSP Study

The Paradoxical Impact of Diabetes Mellitus on Osteoporosis and Sarcopenia: The ParaDOS Study

Association between sarcopenia, its components, and osteoporosis in the FRISBEE cohort.

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