Sarcopenia assessment by new EWGSOP2 criteria for predicting chemotherapy dose-limiting toxicity in patients with gastrointestinal tract tumors

Çelik, Emir; Suzan, Veysel; Samancı, Nilay Şengül; Suzan, Aysegul Akkan; Karadağ, Mehmet; Şahin, Serdar; Aslan, Muhammed Şamil; Yavuzer, Hakan; Demi̇rci, Nebi̇ Serkan; Döventaş, Alper; Demirelli, Fuat

doi:10.1007/s41999-021-00592-3

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…The prevalence of DLT was 54.9% in this study. Previous studies observed similar DLT rates [ 20 , 23 ]. Botsen et al reported 49% of chemotherapy-induced DLT in digestive cancer patients [ 20 ].…”

Section: Discussionsupporting

confidence: 63%

“…Botsen et al reported 49% of chemotherapy-induced DLT in digestive cancer patients [ 20 ]. Celik et al observed 52% of DLT in digestive cancer patients receiving platinum-based chemotherapy [ 23 ]. He also described higher rates (78.9%) in patients with sarcopenia (defined as a low muscle mass measured on a computed tomography), suggesting its potential role in predicting chemotherapy-induced DLT.…”

Section: Discussionmentioning

confidence: 99%

“…He also described higher rates (78.9%) in patients with sarcopenia (defined as a low muscle mass measured on a computed tomography), suggesting its potential role in predicting chemotherapy-induced DLT. Nonetheless, HGS alone seemed to be insufficient to predict the occurrence of DLT [ 23 ]. In another study, Lakenman et al showed an association between low HGS and DLT during neoadjuvant chemoradiation in patients with esophageal cancer [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

et al. 2022

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In the FIGHTDIGO study, digestive cancer patients with dynapenia experienced more chemotherapy-induced neurotoxicities. FIGHTDIGOTOX aimed to evaluate the relationship between pre-therapeutic handgrip strength (HGS) and chemotherapy-induced dose-limiting toxicity (DLT) or all-grade toxicity in digestive cancer patients. HGS measurement was performed with a Jamar dynamometer. Dynapenia was defined according to EWGSOP2 criteria (<27 kg (men); <16 kg (women)). DLT was defined as any toxicity leading to dose reduction, treatment delay, or permanent discontinuation. We also performed an exploratory analysis in patients below the included population’s median HGS. A total of 244 patients were included. According to EWGSOP2 criteria, 23 patients had pre-therapeutic dynapenia (9.4%). With our exploratory median-based threshold (34 kg for men; 22 kg for women), 107 patients were dynapenic (43.8%). For each threshold, dynapenia was not an independent predictive factor of overall DLT and neurotoxicity. Dynapenic patients according to EWGSOP2 definition experienced more hand-foot syndrome (p = 0.007). Low HGS according to our exploratory threshold was associated with more all-grade asthenia (p = 0.014), anemia (p = 0.006), and asthenia with DLT (p = 0.029). Pre-therapeutic dynapenia was not a predictive factor for overall DLT and neurotoxicity in digestive cancer patients but could be a predictive factor of chemotherapy-induced anemia and asthenia. There is a need to better define the threshold of dynapenia in cancer patients.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

et al. 2022

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“…By contrast, recent studies have proposed other mainly imaging-based measures, such as cross-sectional computed tomography, which seem to assess sarcopenia and obesity in this population more accurately [ 50 , 77 , 78 ]. However, only a few studies have evaluated the impact of such measures on the clinical outcomes of adult patients with cancer [ 77 , 79 , 80 ]. Moreover, the prognostic significance of imaging-based measures in children with cancer needs to be further explored, also addressing the potential harms, i.e., those related to exposure to radiation [ 80 ].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature

et al. 2022

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Few studies so far have examined the impact of nutritional status on the survival of children with cancer, with the majority of them focusing on hematological malignancies. We summarized published evidence reporting the association of nutritional status at diagnosis with overall survival (OS), event-free survival (EFS), relapse, and treatment-related toxicity (TRT) in children with cancer. Published studies on children with leukemia, lymphoma, and other solid tumors have shown that both under-nourished and over-nourished children at cancer diagnosis had worse OS and EFS. Particularly, the risk of death and relapse increased by 30–50% among children with leukemia with increased body mass index at diagnosis. Likewise, the risk of TRT was higher among malnourished children with osteosarcoma and Ewing sarcoma. Nutritional status seems to play a crucial role in clinical outcomes of children with cancer, thus providing a significant modifiable prognostic tool in childhood cancer management. Future studies with adequate power and longitudinal design are needed to further evaluate the association of nutritional status with childhood cancer outcomes using a more standardized definition to measure nutritional status in this population. The use of new technologies is expected to shed further light on this understudied area and give room to person-targeted intervention strategies.

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Comprehensive evaluation of older patients with suspected malignancy: 5-year experience of a tertiary geriatric inpatient unit

Kanat

Suzan

Avci

et al. 2023

Current Medical Research and Opinion

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Sarcopenia assessment by new EWGSOP2 criteria for predicting chemotherapy dose-limiting toxicity in patients with gastrointestinal tract tumors

Cited by 4 publications

References 27 publications

Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

Association of Low Handgrip Strength with Chemotherapy Toxicity in Digestive Cancer Patients: A Comprehensive Observational Cohort Study (FIGHTDIGOTOX)

Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature

Comprehensive evaluation of older patients with suspected malignancy: 5-year experience of a tertiary geriatric inpatient unit

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