Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010

Han, Kyungdo; Park, Yu Mi; Kwon, Hyuk Sang; Ko, Seung Hyun; Lee, Seung Hwan; Yim, Hyeon Woo; Lee, Won Chul; Park, Yong Gyu; Kim, Mee Kyoung; Park, Young Jun

doi:10.1371/journal.pone.0086902

Cited by 127 publications

(155 citation statements)

References 26 publications

(32 reference statements)

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“…Thus, visceral fat could increase, although body weight decreased. Sarcopenic obesity is associated with hypertension [35] and CVD [36]. In fact, the individuals who transitioning from MHO to MAO phenotype were older and had higher blood pressure (data not shown).…”

Section: Wwwscidocorg/ijdvrphpmentioning

confidence: 91%

Maintaining Metabolically Healthy Overweight and Risk of Incident Type 2 Diabetes or Cardiovascular Disease

Hashimoto¹,

Tanaka²,

Senmaru³

et al. 2015

IJDVR

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IntroductionObesity [1] and metabolic syndrome [2] are major public health problems worldwide and frequently co-exist. Recent studies have identified a subset of obese individuals who have a low burden of adiposity-related metabolic abnormalities compared with at risk obese individuals, the so-called metabolically healthy obesity phenotype [3][4][5]. Metabolically healthy obesity phenotype is characterized by high levels of insulin sensitivity, low prevalence of hypertension and a favorable fasting glucose, lipid, and inflammation profile, compared with metabolically abnormal obesity phenotype [6]. In fact, we previously reported that not metabolically healthy obesity but metabolically abnormal obesity phenotype was associated with incident chronic kidney disease [7].However, recent studies revealed that metabolically healthy obesity phenotype was also a risk of incident Type 2 diabetes [8][9][10] and cardiovascular disease (CVD) [10][11][12]. On the other hand, among the metabolically healthy obesity individuals, about half of them transit to metabolically abnormal obesity phenotype over time [7,13,14]. Thus, there is a possibility that metabolically healthy obesity individuals, who developed Type 2 diabetes or CVD, transitioned to metabolically abnormal obesity phenotype before incident Type 2 diabetes or CVD. However, evidence of whether AbstractBackground: Recent studies reveal that metabolically healthy obesity, which is free from the metabolic complications of obesity at present, is a risk of incident diabetes or cardiovascular disease (CVD). It may be because many metabolically healthy obesity individuals transit to metabolically abnormal obesity over time. However, the association between maintaining metabolically healthy obesity and incident diabetes or CVD is still unclear. Methods: 2190 participants without diabetes and/or CVD were examined at baseline and at 5-year follow-up, using a retrospective cohort study design. Metabolically abnormal was defined as having ≥ 2 of metabolic abnormalities, hypertension, hypertriglyceridemia, low HDL cholesterol and impaired fasting glucose. Overweight was defined as BMI ≥ 23 kg/ m

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Section: Wwwscidocorg/ijdvrphpmentioning

confidence: 91%

Maintaining Metabolically Healthy Overweight and Risk of Incident Type 2 Diabetes or Cardiovascular Disease

Hashimoto¹,

Tanaka²,

Senmaru³

et al. 2015

IJDVR

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“…After adjusting for confounding factors the group with SO showed a higher chance of dyslipidemia (OR, 2.82; 95% CI, 1.76-4.51) regardless of sex (15). Many cross-sectional studies in the Korean population, especially in elderly subjects (7,10,14,43,44), but also in adults (11,12,45), showed that SO was associated with changes in the lipid profile characterized by elevated levels of triglycerides (TGL) (7,10,14,22,(43)(44)(45), total cholesterol (TC) (22) and reduction of the high density lipoprotein (HDL) (10,11). They used as criterion for diagnosis of sarcopenia, ASM adjusted for body mass and for obesity, BMI > 25 kg/m 2 , the visceral fat area (VFA) by computed tomography (CT) or waist circumference (WC).…”

Section: So and Risk Factors For Cardiometabolic And Cardiovascular Dmentioning

confidence: 99%

“…The association between SO and insulin resistance was described, only in women (11), male (12) or in the both sexes (3,7,9,14,15,43,44). All these studies used HOMA-IR (homeostatic model assessment insulin resistance) to investigated insulin resistance, but different methodologies were used to evaluate sarcopenia: ASM adjusted for body mass (7,11,12,14,15,43,44) or height (9), muscular area in the thigh/visceral fat (3) and the MM index (DEXA) (11) and BMI (12,14,15,43,44), VFA (3,7,11) and WC (9) for evaluate obesity. Individuals with SO showed a higher HOMA-IR when compared to others who were obese, sarcopenic or normal individuals (3,7,9,11,12,14,15,43,44).…”

Section: So and Risk Factors For Cardiometabolic And Cardiovascular Dmentioning

confidence: 99%

“…The association with hypertension is the most studied. Studies evaluating sarcopenia by ASM adjusted for body mass (12,14,21,44,45,51) and SMI (19) and obesity by BMI (12,14,21,44), the WC (45,51) andVFA (19) showed that both men and women with SO had higher blood pressure values compared with sarcopenic, obese or normal individuals (12,14,19,21). Individuals with SO also had higher prevalence of (44,45) and a higher odds ratio of developing hypertension compared to normal subjects (44,51).…”

Section: So Cardiometabolic and Cardiovascular Diseasesmentioning

confidence: 99%

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Association between sarcopenic obesity and cardiovascular risk: where are we?

Gusmão-Sena¹,

Curvello-Silva

Barreto-Medeiros

et al. 2016

Nutr Hosp

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ResumenIntroducción: los principales cambios en la composición del cuerpo refi eren el incremento de tejido adiposo y/o la disminución de masa muscular, y estos cambios tienen efecto en varios resultados clínicos. La obesidad sarcopénica (OS) consiste en la presencia simultánea del exceso de tejido adiposo y el défi cit de masa muscular. Las personas con OS pueden tener un efecto sinérgico debido a la obesidad y la sarcopenia, lo que incrementa el riesgo de enfermedad cardiovascular, más que la obesidad en sí. Objetivo: describir los hallazgos en la literatura científi ca sobre la asociación de la SO y los factores de riesgo y/o ECM (enfermedad cardiometabólica) o enfermedad cardiovascular (ECV). Métodos: se realizó una búsqueda electrónica en las siguientes bases de datos: MEDLINE, Scopus, SciELO, LILACS y Web of Science, usando las expresiones coincidentes y los operadores booleanos: "obesidad sarcopénica" o " sarcopénica obesidad ", en los títulos de los estudios, y "enfermedad cardiometabólica" o "enfermedad cardiovascular" o "síndrome metabólico" o "resistencia a la insulina", en el abstract. Resultados: la mayoría de los estudios son de corte transversales y presentan diferentes criterios de diagnóstico para la OS. Fue posible verifi car la asociación de la OS y los factores de riesgo y/o ECM o ECV. Conclusión: la OS está asociada con los factores de riesgo y/o ECM o ECV. La falta de un consenso sobre esta defi nición pone en peligro la efectividad de la práctica clínica y la investigación sobre el tema. AbstractIntroduction: The main changes in the body composition refer to the increase of adipose tissue and/or the decrease of muscular mass, and these changes have effect in many clinical outcomes. Sarcopenic obesity (SO) consists of the presence of excessive adipose tissue and defi cit of muscular mass simultaneously. People with SO may have synergistic effect due to obesity and sarcopenia, with increases cardiovascular risk more than obesity itself. Objective: To describe the fi ndings in the literature about the association between SO and risk factors and/or cardiometabolic disease (CMD) or cardiovascular disease (CVD). Methods: An electronic search was done on the following databases: MEDLINE, Scopus, SciELO, LILACS and Web of Science, using the matching expressions and Boolean operators: "obesity sarcopenic" OR "sarcopenic obesity", in the titles of the studies, AND "cardiometabolic disease" OR "cardiovascular disease" OR "metabolic syndrome" OR "insulin resistance", in the abstract. Results: Most of studies are cross-sectional and present many different diagnosis criteria for SO. It was possible to verify the association of the SO and the risk factors and/or CMD or CVD. Conclusion: SO is associated with risk factors and/or CMD or CVD. The lack of a consensus about this defi nition jeopardizes the effective clinical practice and the research about the subject.

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“…Uma das doenças cardiovasculares que está associada ao processo de envelhecimento e sarcopenia é a HAS (CHUNG et al, 2013;HAN et al, 2014;PARK et al, 2013 …”

Section: Senescênciaunclassified

Magnitude e duração da resposta hipotensora em hipertensos: efeitos do exercício físico contínuo e intervalado

Carvalho¹

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Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010

Cited by 127 publications

References 26 publications

Maintaining Metabolically Healthy Overweight and Risk of Incident Type 2 Diabetes or Cardiovascular Disease

Maintaining Metabolically Healthy Overweight and Risk of Incident Type 2 Diabetes or Cardiovascular Disease

Association between sarcopenic obesity and cardiovascular risk: where are we?

Magnitude e duração da resposta hipotensora em hipertensos: efeitos do exercício físico contínuo e intervalado

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