Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men

Verschueren, Sabine; Gielen, Evelien; O'Neill, Terence W; Pye, Stephen R.; Adams, Judith E.; Ward, Kate A; Wu, Frederick C. W.; Szulc, Paweł; Laurent, Michaël; Claessens, Frank; Vanderschueren, Dirk; Boonen, Steven

doi:10.1007/s00198-012-2057-z

Cited by 259 publications

(216 citation statements)

References 54 publications

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, Janssen et al (2002) reported a large-scale cross-sectional study using bioelectric impedance analysis and found that the prevalence of severe sarcopenia was less than 5 % for men and women aged 49 years or younger and approximately 10 % for men and women aged 70 years or older. In the present study, the prevalence rate of severe sarcopenia was relatively higher in nonobese men compared with those of the previous studies and was consistent with previous studies in women (Baumgartner et al 1998;Bijlsma et al 2013;Chien et al 2008;Dufour et al 2012;Janssen et al 2002;Kim et al 2012;Masanes et al 2012;Rolland et al 2003;Tanimoto et al 2012;Tichet et al 2008;Verschueren et al 2012). Taken together with previous studies (Fig.…”

Section: Discussionsupporting

confidence: 93%

Prevalence of site-specific thigh sarcopenia in Japanese men and women

Abe

Thiebaud

Loenneke

et al. 2013

AGE

View full text Add to dashboard Cite

The purpose of this study was to compare the prevalence of severe sarcopenia detected by total skeletal muscle mass (SM) index and of site-specific thigh sarcopenia for differing age groups in men and women. Japanese nonobese men and women aged 20 to 85 (n=1,994, 55 % women) had muscle thickness (MTH) measured by ultrasound at six sites on the anterior and posterior aspects of the body. SM was estimated from ultrasound-derived prediction equations. Site-specific thigh sarcopenia was calculated using ultrasoundmeasured MTH at the anterior and posterior aspects of the thigh (MTH ratio, anterior 50 %/posterior 50 % thigh MTH (A50/P50 MTH)). Sarcopenia was defined as a SM index (SM divided by height 2 ) of >2 standard deviations (SD) below the mean for young adults. Sitespecific thigh sarcopenia was defined as a ratio of A50/P50 MTH of >2 SD below the mean for young adults. Age was inversely correlated to SM index and A50/P50 MTH in men (r=−0.480 and r=−0.522) and women (r=−0.243 and r=−0.516). The prevalence rate of sarcopenia was less than 3 % for women under the age of 60, 7 % for ages 60-69, and 24 % for ages 70-80. In men, the prevalence rate of sarcopenia was less than 7 % under the age of 50, 18 % for ages 50-59, 33 % for ages 60-69, and 47 % for ages 70-85. Compared to the sarcopenia estimated by SM index, there was a higher prevalence of site-specific thigh sarcopenia observed in both sexes. These results suggest that site-specific thigh sarcopenia appears before it is able to be detected at the whole body level.

show abstract

Section: Discussionsupporting

confidence: 93%

Prevalence of site-specific thigh sarcopenia in Japanese men and women

Abe

Thiebaud

Loenneke

et al. 2013

AGE

View full text Add to dashboard Cite

show abstract

“…The association between sarcopenia and bone mass demonstrated in this study is consistent with the hypothesis of previous studies showing a reduction in osteogenic effect due to a minor mechanical stimulation imposed on the bone structure by reducing the muscle and muscle function (4,6,15). Another point would be the reduction of the mechanical stimuli from less physical activity due to a lower functional capacity of the elderly caused by sarcopenia (12).…”

Section: Sarcopenia and Osteoporosis In Mensupporting

confidence: 91%

“…Sarcopenia has emerged as an important risk factor for osteoporosis (3,4). In addition to increasing falls risk, sarcopenia might also decrease bone strength by reducing mechanical loading to the skeleton.…”

Section: Introductionmentioning

confidence: 99%

Relationship between pre-sarcopenia, sarcopenia and bone mineral density in elderly men

Pereira

Leite

Paula

2015

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objective: Analyze the influence of sarcopenia in bone health of elderly men. Subjects and me thods: This cross-sectional study evaluated 198 men aged over 60 years. Body composition was measured by dual energy X-ray absorptiometry. The BMD was measured at the femoral neck, total hip, lumbar spine and 33% radius. The diagnosis of abnormal BMD was defined for men who presented densitometric diagnosis of osteopenia or osteoporosis defined by T-score of femoral neck, total hip and lumbar spine. The pre-sarcopenia and sarcopenia were defined according to the European Working Group on Sarcopenia in Older People. Results: The group diagnosed with normal BMD, compared to the group of abnormal BMD, have significantly higher body weight, body mass index, grip strength, lean mass, fat mass, and relative appendicular skeletal muscle mass (RASM). However, after multiple linear regression analysis, we found that only the RASM, lean mass, and handgrip strength in the dominant hand influenced the variability of the BMD after adjustment for age and weight. Regression analyzes showed a positive association between greater appendicular lean mass and a smaller number of elderly patients with abnormal BMD diagnostic. The regression analyzes showed that elderly men diagnosed with pre-sarcopenia and sarcopenia had more abnormal BMD than non-sarcopenic elderly men. Conclusion: We concluded that pre-sarcopenia and sarcopenia were associated with abnormal BMD. The lean mass, compared to fat mass, has a greater positive influence on the BMD of elderly men. This result suggests the importance of the increase in lean mass for the bone health of elderly men. Arch Endocrinol Metab. 2015;59(1):59-65

show abstract

“…Sarcopenia has been found to be an independent predictor of physical disability and development of mobility disorders, as well as reduced bone mineral density [27,34,35]. Diagnosis is usually through identifying loss of lean body mass (e.g.…”

Section: Development Of Frailtymentioning

confidence: 99%

Musculoskeletal health, frailty and functional decline

Milte

Crotty

2014

Best Practice & Research Clinical Rheumatology

View full text Add to dashboard Cite

Frailty in older people is associated with a vulnerability to adverse events. While ageing is associated with a loss of physiological reserves identifying those with the syndrome of frailty has the potential to assist clinicians tailor treatments to those at risk of future decline into disability with increased risk of complications, morbidity and mortality. Sarcopenia is a key component of the frailty syndrome and on its own puts older people at risk of fragility fractures however the clinical syndrome of frailty affects musculoskeletal and non musculoskeletal systems. Hip fractures are becoming a prototype condition in the study of frailty. Following a hip fracture many of the interventions are focused on limiting mobility disability and restoring independence with activities of daily living but there are multiple factors to be addressed including osteoporosis, sarcopenia, delirium, weight loss. Established techniques of geriatric evaluation and management allow systematic assessment and intervention on multiple components by multidisciplinary teams and deliver the best outcomes. Using the concept of frailty to identify older people with musculoskeletal problems as at risk of a poor outcome assists in treatment planning and is likely to become more important as effective pharmacological treatments for sarcopenia emerge. This review will focus on the concept of frailty and its relationship with functional decline, as well as describing its causes, prevalence, risk factors and potential clinical applications and treatment strategies. Key wordsFragility fracture, frailty, functional decline, screening, older adult, exercise therapy, dietary therapy Word count 9,401 words (word limit=9,400)

show abstract

Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men

Abstract: Sarcopenia is associated with low BMD(a) and osteoporosis in middle-aged and elderly men. Further studies are necessary to assess whether maintaining muscle mass contributes to prevent osteoporosis.

Cited by 259 publications

References 54 publications

Prevalence of site-specific thigh sarcopenia in Japanese men and women

Prevalence of site-specific thigh sarcopenia in Japanese men and women

Relationship between pre-sarcopenia, sarcopenia and bone mineral density in elderly men

Musculoskeletal health, frailty and functional decline

Contact Info

Product

Resources

About