Sarcopenia and health‐related quality of life: A systematic review and meta‐analysis

Abstract

The decrease of physical abilities and functional decline that can be caused by musculoskeletal conditions such as sarcopenia, can lead to higher levels of dependency and disability. Therefore, it may influence patient reported outcome measures (PROM), such as the health‐related quality of life (HRQoL). The purpose of this systematic review and meta‐analysis is to provide a comprehensive overview of the relationship between sarcopenia and HRQoL. Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) were followed throughout the whole process of this work. A protocol was previously published on PROSPERO. The electronic databases MEDLINE, Scopus, Allied and Complementary Medicine (AMED), EMB Review – ACP Journal Club, EBM Review ‐ Cochrane Central of Register of Controlled Trials and APA PsychInfo were searched until October 2022 for observational studies reporting a HRQoL assessment in both sarcopenic and non‐sarcopenic individuals. Study selection and data extraction were carried out by two independent researchers. Meta‐analysis was performed using a random effect model, reporting an overall standardized mean difference (SMD) and its 95% confidence interval (CI) between sarcopenic and non‐sarcopenic individuals. Study quality was measured using the Newcastle‐Ottawa Scale and the strength of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool. The search strategy identified 3725 references from which 43 observational studies were eligible and included in this meta‐synthesis study. A significantly lower HRQoL was observed for sarcopenic individuals compared with non‐sarcopenic ones (SMD −0.76; 95% CI −0.95; −0.57). Significant heterogeneity was associated with the model (I2 = 93%, Q test P‐value <0.01). Subgroup analysis showed a higher effect size when using the specific questionnaire SarQoL compared with generic questionnaires (SMD −1.09; 95% CI −1.44; −0.74 with the SarQoL versus −0.49; 95% CI −0.63; −0.36 with generic tools; P‐value for interaction <0.01). A greater difference of HRQoL between sarcopenic and non‐sarcopenic was found for individuals residing in care homes compared with community‐dwelling individuals (P‐value for interaction <0.001). No differences were found between age groups, diagnostic techniques, and continents/regions. The level of evidence was rated as moderate using the GRADE assessment. This systematic review and meta‐analysis combining 43 observational studies shows that HRQoL is significantly reduced in sarcopenic patients. The use of disease‐specific HRQoL instruments may better discriminate sarcopenic patients with respect to their quality of life.

Association of muscle strength and physical performance with the health-related quality of life of women with breast cancer

“…Decreased physical skills and functional decline can lead to higher levels of dependence and disability. These adverse conditions, which can be caused by musculoskeletal conditions such as sarcopenia, are unfavorable and undesirable, having a direct impact on HRQoL [12].…”

“…In fact, this relationship is even less described in women with breast cancer. Our hypothesis is that there is a relationship between the amount of muscle mass and HRQoL, so that low muscle mass negatively impacts the HRQoL of women with breast cancer, mainly by leading to reduced or interrupted response to treatment, hospitalizations, and low functionality [5,12]. However, the different cutoff points used to classify low muscle mass in the literature limits the interpretation of this relationship, meaning that the prevalence of low muscle mass in cancer patients varies depending on the type of muscle measurement considered [44,45].…”

“…HRQoL was found to be positively in uenced by an improvement in the state of sarcopenia. Thus, understanding this relationship between sarcopenia and HRQoL can guide the development of care actions, as well as the reduction of the disease's impacts [12].…”

Validity and reliability of Sarcopenia Quality of Life® Indonesia questionnaire in sarcopenic patients

“…Sarcopenia significantly impairs quality of life (QoL). A systematic review and meta-analysis 11 reported lower QoL in sarcopenic subjects based on generic QoL questionnaires, such as 36-Item Short Form Health Survey (SF-36) or EuroQol-5 dimension (EQ-5D) or EuroQol-visual analog scales (EQ-VAS). In SF-36, sarcopenic subjects mainly reported lower physical function [12][13][14][15] and general health, [13][14][15] while other studies [14][15][16] also reported lower scores in other SF-36 domains.…”