Sarcoidosis with Acute Recurrent Polyarthritis and Hypercalcemia

Sato, Takeo; Tsuru, Tsunehisa; Hagiwara, Kaoru; Miyashita, Kazuhisa; Matsuno, Hiroaki; Goto, Atsuo; Oritsu, Masaru; Hamanaka, Teruhiko; Akiyama, Osamu

doi:10.2169/internalmedicine.45.1521

Cited by 11 publications

(9 citation statements)

References 16 publications

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“…[3], all patients had peripheral arthritis and hilar adenopathy, and 87.8% presented with EN. Sato et al [10] summarized the reported 13 patients of Lofgren's syndrome in Japan. BHL was observed in almost all patients (85%), but EN was not observed in 38% of the patients.…”

Section: Discussionmentioning

confidence: 99%

Lofgren's Syndrome-Acute Onset Sarcoidosis and Polyarthralgia: A Case Report

et al. 2013

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Lofgren's syndrome is an acute form of sarcoidosis characterized by erythema nodosum, bilateral hilar lymphadenopathy (BHL), and polyarthralgia or polyarthritis. This syndrome is common among Caucasians but rare in the Korean population. A 44-year-old woman was admitted to our hospital complaining of polyarthralgia. A chest radiograph revealed BHL and nodular shadows. Angiotensin-converting enzyme levels were within the normal range. Tissue biopsy from a mediastinum lymph node showed noncaseating granulomas. We diagnosed her with Lofgren's syndrome, an acute form of sarcoidosis.

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Section: Discussionmentioning

confidence: 99%

Lofgren's Syndrome-Acute Onset Sarcoidosis and Polyarthralgia: A Case Report

et al. 2013

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“…First, sarcoidosis‐related fever was difficult diagnose on account of the malignancy. By means of searching PubMed, we found reports of 25 cases of sarcoidosis in hemodialysis patients since 2000 (summarized in Table ) . Of the 25 cases, four presented fever and one was complicated with tumor.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review

Shima¹,

Nishitani²,

Tashiro³

et al. 2019

Hemodialysis International

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Hemodialysis patients have weakened immune systems and can exhibit fever due to various causes. Herein, we describe the case of a 61‐year‐old hemodialysis patient who exhibited intermittent low‐grade fever after a pacemaker had been implanted 2 months before due to sick sinus syndrome. She had a medical history of subcutaneous sarcoidosis and uveitis. Active pulmonary sarcoidosis was diagnosed based on elevated soluble interleukin‐2 receptor, elevated lysozyme level, and gallium‐67 scintigraphy uptake in hilar and mediastinal lymph nodes. She was also diagnosed with renal cell carcinoma via contrast computed tomography. However, because her C‐reactive protein level remained normal, the possibility of neoplastic fever was considered low. After the initiation of prednisolone administration, her fever gradually disappeared. Her serum soluble interleukin‐2 receptor and lysozyme level improved in parallel with the enlargement of the mediastinal lymph node and gallium‐67 scintigraphy uptake.

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“…To the best of our knowledge, only 23 cases of sarcoidosis in chronic dialysis patients have been reported (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). Their clinical characteristics, laboratory data, and treatment are listed in Table 2.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis in a Chronic Dialysis Patient Diagnosed by Sarcoidosis-related Hypercalcemia with No Common Systemic Clinical Manifestations: A Case Report and Review of the Literature

et al. 2013

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Sarcoidosis is a systemic granulomatous disease of unknown origin. We herein report a case of sarcoidosis in a chronic dialysis patient diagnosed by hypercalcemia without any common clinical manifestations. The onset of sarcoidosis in chronic dialysis patients is rare; to the best of our knowledge, only 23 cases have been reported. Evaluation of the 23 previously published cases revealed that a diagnosis of sarcoidosis was often achieved by the presence of sarcoidosis-related hypercalcemia without any common clinical presentations, as in the present case. This characteristic may arise from a specific immune deficiency and the unique physiology of 1,25-dihydroxyvitamin D3, a main cause of sarcoidosis-related hypercalcemia, in chronic dialysis patients. These clinical features may be useful to understand the pathogenesis of sarcoidosis.

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Sarcoidosis with Acute Recurrent Polyarthritis and Hypercalcemia

Abstract: A 45-year-old

Cited by 11 publications

References 16 publications

Lofgren's Syndrome-Acute Onset Sarcoidosis and Polyarthralgia: A Case Report

Lofgren's Syndrome-Acute Onset Sarcoidosis and Polyarthralgia: A Case Report

Pulmonary sarcoidosis as a cause of intermittent fever of unknown origin in a hemodialysis patient with renal cell carcinoma: A case report and literature review

Sarcoidosis in a Chronic Dialysis Patient Diagnosed by Sarcoidosis-related Hypercalcemia with No Common Systemic Clinical Manifestations: A Case Report and Review of the Literature

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