Sarcoidosis in Causians, Blacks and Asians in London

Edmondstone, W M; Wilson, Alan

doi:10.1016/0007-0971(85)90004-x

Cited by 103 publications

(71 citation statements)

References 11 publications

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“…33 This threefold increase in the incidence of sarcoidosis in black patients of African descent is lower than previous estimates, which had shown up to 10 times more cases of sarcoidosis in AfricanAmericans than in European Americans. 34,35 A higher prevalence of sarcoidosis in people of African descent has also been observed in the U.K.; 36 in this study, Indo-Pakistan Asians also showed a high prevalence of sarcoidosis. By contrast, Chinese and Japanese Asians appeared to be less prone than other ethnic groups to develop this disease, 37 with annual incidences of only 0Á73 and 1Á28/100 000 for Japanese men and women, respectively.…”

Section: Sarcoidosissupporting

confidence: 63%

“…Variations of incidence in a relatively homogeneous population according to the place of residence suggests a role for environmental factors, as observed in North compared with South Italy, or in Irish people living in London, compared with those living in Ireland. 36,40 Connubial cases, seasonal influences and small 'epidemics' of sarcoidosis have been described in the past, suggesting a role for infectious agents. 39 Exposure to pollutants could be involved in the increased incidence of the disease observed in New York firefighters, especially after the 2001 World Trade Centre disaster, although exposure to the dust cloud does not appear to have been a risk factor.…”

Section: Sarcoidosismentioning

confidence: 99%

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Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Petit

Dadzie

2013

Br J Dermatol

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Section: Sarcoidosissupporting

confidence: 63%

Section: Sarcoidosismentioning

confidence: 99%

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Petit

Dadzie

2013

Br J Dermatol

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“…No association was found between either the ACE I/D or TNF-307 polymorphisms and disease phenotype, which would suggest that neither of these polymorphisms are related to disease progression in African Americans and that the case mix in the present study population did not influence its susceptibility results. If the TNF-307 polymorphism is actually a marker for Lofgrens syndrome and erythema nodosum in sarcoidosis, as several studies report [17,42], then these conditions being rare in African-American sarcoidosis cases [43] may explain the negative findings with respect to this polymorphism in the current study. However, the extent to which the current authors could exclude a disease progression gene was limited by a smaller sample size due to missing and incomplete phenotype data, which did not allow the present study to consider the full range of phenotypic expressions the genes under study could exhibit.…”

Section: Discussionmentioning

confidence: 64%

Sarcoidosis and granuloma genes: a family-based study in African-Americans

Rybicki¹,

Maliarik²,

Poisson³

et al. 2004

Eur Respir J

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The evidence for a genetic component in the aetiology of sarcoidosis includes familial aggregation, associations with genetic polymorphisms, and linkage to the major histocompatibility complex class region on chromosome 6p. Unfortunately, the majority of genetic associations with sarcoidosis have not been consistently replicated.In the present study, using a family-based study design, which controls for population stratification, the authors attempted to replicate previously reported associations between sarcoidosis and three attractive candidate genes studied primarily in casecontrol samples.In 225 nuclear families, ascertained through African Americans with a history of sarcoidosis, no evidence was found for an association between sarcoidosis susceptibility and polymorphisms in the angiotensin converting enzyme, vitamin D receptor and tumour necrosis factor-a genes. Further analyses of chronic and acute disease phenotypes failed to reveal any notable associations. Assuming an underlying inheritance model with an additive allelic effect on disease risk, the current study had y80-90% statistical power to detect a 3-fold increased risk associated with the putative risk allele of the polymorphisms under study.The present authors conclude that in African-Americans, the angiotensin converting enzyme, vitamin D receptor, and tumour necrosis factor-a genes are not significant risk factors for sarcoidosis susceptibility.

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“…In the west regarding ethnicity is concerned, the Puerto Ricans in America and the Scandinavians in Europe suffer from this disease more commonly, also blacks are several times more affected compared to whites. [9][10][11] The clinical presentation and natural course of sarcoidosis vary greatly. 12 Although almost any organ of the body can be affected, the lungs or intrathoracic lymph node are involved in almost all the cases (>90%).…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis in Nepal: Epidemiology, Clinical Presentation and Ethnic Differences

Pathak

Pant

Chokhani

2017

J Coll Med Sci-Nepal

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Background & Objectives:Sarcoidosis is a multi-system granulomatous disorder of unknown origin.The frequency and the clinical presentation of sarcoidosis vary among the geographical regions. This study is a retrospective analysis of the sarcoidosis patients diagnosed in Nepalese population. The aim of this study was to find the prevalence of sarcoidosis in Nepalese population which has high prevalence of tuberculosis and to understand the clinical profiles and ethnic differences. Materials & Methods: A retrospective chart analysis was done in all the patients from January first, 2005 to December 31st, 2010 who had abnormal chest radiograph and who were diagnosed with sarcoidosis. The study was done at Nepal Medical College Teaching Hospital and Everest Nursing Home. Results: A Forty two patients were diagnosed to have sarcoidosis over a five year period, of which 23/42 (55.0%) were females and 19/42 (45%) were males. The mean age was 36 years with minimum age being 18 years and maximum 72 years. As far as Ethnicity is concerned, 15/42 (36.0%)were Brahmins,08/42(19.0%) were Marwadi, and 07/42(17.0%) were Chhetri. The most common presenting symptom was cough 19/42 (45.0%).Out of the 42 patients, eight were being treated for pulmonary tuberculosis. Most common radiographic findings were bilateral hilar lymphadenopathy15/42 (36.0%). Conclusion: Sarcoidosis is common in Nepal and should be considered in the differential diagnosis before treating the patient empirically for tuberculosis.

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Sarcoidosis in Causians, Blacks and Asians in London

Cited by 103 publications

References 11 publications

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Multisystemic diseases and ethnicity: a focus on lupus erythematosus, systemic sclerosis, sarcoidosis and Behçet disease

Sarcoidosis and granuloma genes: a family-based study in African-Americans

Sarcoidosis in Nepal: Epidemiology, Clinical Presentation and Ethnic Differences

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