Sarcoidosis and Multiple Myeloma: A Case Report and Literature Review

Serra, Joao Tiago; Martinho, Aurélia; Duarte, Fernanda; Aldomiro, Fernando

doi:10.1155/2019/4586265

Cited by 9 publications

(7 citation statements)

References 21 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osseous lesions were found in the spine and were accompanied by ocular and nodular involvement. Similar cases are summarized by Tiago Serra et al [49]. Association of sarcoidosis with lymphoma has been sporadically reported as well.…”

Section: Detection Of Osseous Involvement In Patients With Sarcoidosissupporting

confidence: 71%

Osseous manifestations of sarcoidosis

2020

View full text Add to dashboard Cite

Sarcoidosis is a systemic multisystem inflammatory disease of unknown etiology. The disease is characterized by formation of non-caseating granulomas. The most common presentation is bilateral hilar lymphadenopathy and lung infiltration, but the disease is very heterogeneous, with an unpredictable clinical course. Musculoskeletal manifestations are common. Bone involvement is less frequent, and usually occurs in patients with chronic multisystem course of the disease. They are most commonly found in the phalanges of hands and feet, and are usually bilateral. The skull, long bones, ribs, pelvis, and axial skeleton may also be affected. Osseous involvement may be asymptomatic but in some cases can cause a severe disability. Imaging techniques are important for diagnosis. Radiological investigations revealed sclerotic or destructive lesions (involving also joints), cystic and punched out lesions and cortical abnormalities. Biopsy is required for differential diagnosis with respect to malignancy. Treatment is a part of systemic therapy and is not needed in all cases. Glucocorticoids and TNF-α antagonists are used for management.

show abstract

Section: Detection Of Osseous Involvement In Patients With Sarcoidosissupporting

confidence: 71%

Osseous manifestations of sarcoidosis

2020

View full text Add to dashboard Cite

show abstract

“…There are a number of possible explanations for these associations, including immune system dysregulation with activation of CD4+T-helper/inducer cells, increased secretion of various cytokines and decreased CD8+T-suppressor/cytotoxic cells 14. On review of the previous cases of sarcoidosis in association with multiple myeloma reported in the literature, the median age at diagnosis of the sarcoidosis is older than that reported for cases of sarcoidosis diagnosed in the general population 9. There is also a female predominance among the reported of sarcoidosis in association with multiple myeloma 9.…”

Section: Discussionmentioning

confidence: 86%

“…The association between sarcoidosis and lymphoma is well established and the sarcoidosis-lymphoma syndrome was first described in 1986 by Brincker and Wilbek 8. However, there are very few reports of an association between sarcoidosis and multiple myeloma 9–12. Herein, we report a case of paraneoplastic sarcoidosis occurring in a patient progressing from smouldering to symptomatic multiple myeloma.…”

Section: Introductionmentioning

confidence: 82%

See 1 more Smart Citation

Dual pathology: paraneoplastic sarcoidosis emerging at the time of progression from smouldering to symptomatic myeloma

Aquil,

Giles,

Buka

et al. 2023

BMJ Case Rep

View full text Add to dashboard Cite

Sarcoidosis is a systemic disease of unknown aetiology, which is diagnosed based on the presence of non-caseating granulomas on histology. The occurrence of sarcoidosis or a sarcoidosis-like reaction with malignancy has been recognised for several years. Although it has been established that there is an increased risk of lymphoproliferative disorder with sarcoidosis, the association between multiple myeloma and sarcoidosis has rarely been reported. Here, we report the case of woman in her mid-50s with an established diagnosis of smouldering myeloma, who presented with gradually worsening shortness of breath and fatigue after 15 months of active observation. A CT scan of her thorax showed mediastinal lymphadenopathy and the nodes were metabolically active on positron emission tomography CT scan. Endobronchial ultrasound with transbronchial needle aspiration confirmed the diagnosis of sarcoidosis. Further evaluation showed preserved lung function on spirometry. Blood analysis showed a simultaneous rise in the serum lambda-free light chain level from 377 mg/L at initial diagnosis up to 807 mg/L with the kappa/lambda ratio falling to 0.012. Repeat bone marrow aspirate and trephine biopsy showed a 15%–20% infiltrate of lambda light chain-restricted plasma cells with aberrant cyclin D1 expression and abundant sarcoid-like non-necrotising giant cell granulomata. Thus, a diagnosis of paraneoplastic sarcoidosis was established.

show abstract

“…Some patients with sarcoidosis and myeloma may present AKI, associated with hypergammaglobulinemia, normal albuminemia and hypercalcemia. In these cases, the differential diagnosis between sarcoidosis and multiple myeloma may be difficult ( 44 , 45 ). Bone marrow biopsy, showing non-caseating granulomas or prompt improvement of hypercalcemia and kidney function after corticosteroid administration may lead to a correct diagnosis ( 46 ).…”

Section: Methodsmentioning

confidence: 99%

Renal replacement therapy in sarcoidosis

Calatroni

Moroni

Ponticelli³

2023

Front. Med.

View full text Add to dashboard Cite

Sarcoidosis is a systemic inflammatory disease of unknown etiology. Kidney involvement in sarcoidosis may be present in up 25–30% of cases. An early diagnosis and prompt treatment with corticosteroids can improve the prognosis but rarely renal sarcoidosis can lead to kidney failure needing renal replacement therapy (RRT). Acute kidney injury (AKI) in sarcoidosis may be caused by granulomatous interstitial nephritis (GIN) or hypercalcemia. These disorders are usually clinically silent and may lead end stage renal disease (ESKD) if not diagnosed or detected too late. In patients with ESKD, dialysis and renal transplantation can offer results comparable to those observed in patients with other causes of kidney failure. Based on a review of literature, we present an overview of RRT in patients with AKI or chronic kidney disease (CKD) caused by sarcoidosis.

show abstract

Sarcoidosis and Multiple Myeloma: A Case Report and Literature Review

Cited by 9 publications

References 21 publications

Osseous manifestations of sarcoidosis

Osseous manifestations of sarcoidosis

Dual pathology: paraneoplastic sarcoidosis emerging at the time of progression from smouldering to symptomatic myeloma

Renal replacement therapy in sarcoidosis

Contact Info

Product

Resources

About