Sarcoidosis and coeliac disease: do not forget the association!

D’Ercole, Cristina; Zullo, Angelo; Bragazzi, Maria Consiglia; Campo, Salvatore Maria Antonio

doi:10.1007/s11739-011-0561-3

Cited by 11 publications

(7 citation statements)

References 5 publications

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“…Sarcoidosis has been associated with different autoimmune disorders and among them with CD, as both diseases seem to share some immunological and genetic disorders [194–197]. CD has been associated with an increased risk of sarcoidosis (HR 4.03; 95% CI, 2.32–7.00).…”

Section: Autoimmune Disorders In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Autoimmune-Associated Conditions

Lauret

Rodrigo

2013

BioMed Research International

149

111

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Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage.

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Section: Autoimmune Disorders In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Autoimmune-Associated Conditions

Lauret

Rodrigo

2013

BioMed Research International

149

111

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“…A study using the database of the Rochester Epidemiology Project from Olmsted County, Minnesota, found the annual incidence of sarcoidosis of approximately 10 per 100 000 population . Interestingly, several case reports have suggested a possible relationship between celiac disease and sarcoidosis . Shared genetic predisposition, especially HLA‐DR3 and immune cross‐reactivity between gluten proteins and self‐antigens could be the biological links behind the two diseases .…”

Section: Introductionmentioning

confidence: 99%

“…14 Interestingly, several case reports have suggested a possible relationship between celiac disease and sarcoidosis. [15][16][17][18] Shared genetic predisposition, especially HLA-DR3 and immune cross-reactivity between gluten proteins and self-antigens could be the biological links behind the two diseases. [19][20][21] This association was later observed in epidemiological studies as well although the results were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

Wijarnpreecha

Panjawatanan

Corral

et al. 2019

J Evidence Based Medicine

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Background/objectives Several epidemiologic studies have suggested that patients with celiac disease may be at an increased risk of sarcoidosis but the results were inconsistent. This systematic review and meta‐analysis was conducted with the aim to better characterize this risk by summarizing all available data. Methods A literature review was performed using MEDLINE and EMBASE database from inception to February 2019. Studies that compared the risk of sarcoidosis among patients with celiac disease versus individuals without celiac disease were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random‐effect, generic inverse variance method. Results Of 426 retrieved studies, four studies with 693 639 participants met the eligibility criteria and were included in meta‐analysis. The risk of sarcoidosis among patients with celiac disease was higher than individuals without celiac disease with the pooled OR of 7.16 (95% CI, 1.48‐34.56). The statistical heterogeneity of this study was high (I2 = 95%). Conclusions This systematic review and meta‐analysis found a significantly higher risk of sarcoidosis among patients with celiac disease.

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“…Studier viser at ekstra-intestinale manifestasjoner er meget vanlig (21,22), inkludert symptomer som kan ligne revmatiske sykdommer (21). Sarkoidose og cøliaki er assosiert med bestemte vevstyper, HLA-DR3 og HLA-DQ2 (23,24), der sistnevnte forelå hos vår pasient. En assosiasjon mellom disse to lidelsene finnes trolig (23,24), og flere har foreslått å screene for cøliaki hos pasienter med sarkoidose (25).…”

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