Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

Wijarnpreecha, Karn; Panjawatanan, Panadeekarn; Corral, Juan E.; Lukens, Frank; Ungprasert, Patompong

doi:10.1111/jebm.12355

Cited by 15 publications

(8 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the outcome was relatively uncommon when comparing each outcome in different treatments, we used odds ratio (OR) and its 95% CIs of case-control studies as an estimate for risk ratio (RR) and its 95% CIs to combine the effect estimate with RR from RCTs, NRCTs and cohort studies. 26 RR or OR suggested a higher risk of AEs in the RTX group than in the control group when the value exceeded 1. Heterogeneity was quantified by using the chi-square-based-Q-statistics test and I2 test (P > 0.10 and I2 < 50% indicated acceptable heterogeneity, with the N – 1 degrees of freedom).…”

Section: Methodsmentioning

confidence: 92%

Adverse events of rituximab in neuromyelitis optica spectrum disorder: a systematic review and meta-analysis

Wang

Zhou

et al. 2021

Ther Adv Neurol Disord

View full text Add to dashboard Cite

Background: The adverse events (AEs) of rituximab (RTX) for neuromyelitis optica spectrum disorder (NMOSD) are incompletely understood. Aim: To collate information on the reported the AEs of RTX in NMOSD and assess the quality of evidence. Methods: PubMed, EMBASE, Web of Science, Cochrane Library, Wanfang Data, CBM, CNKI, VIP, clinicaltrials.gov, and so on were searched for studies with control groups as well as for case series that had assessed the RTX-associated AEs. The incidence of AEs and the comparison of AE risks among different therapies were pooled. The GRADE was developed for evidence quality. Results: A total of 3566 records were identified. Finally, 36 studies (4 RCTs, 6 crochet studies, 2 NRCTs, and 24 case series), including 1542 patients (1299 females and 139 males), were included for final analyses. Rates of patients with any AEs, any serious AEs (SAEs), infusion-related AEs, any infection, respiratory infection, urinary infection, and death were 28.57%, 5.66%, 27.01%, 17.36%, 4.76%, 4.76%, and 0.17%, respectively. The results from subgroup analysis showed that AE rates were most likely not associated with covariates such as duration of illness and study designs. Very low-quality evidence suggested that the risk ratios (RR) of any AEs (0.84, 95% CI = 00.42–1.69, p = 0.62) and any infections (1.24 95% CI = 0.18–8.61) of RTX were similar to that of azathioprine, and the RR of any AEs of RXT was akin to that of mycophenolate mofetil (0.66, 95% CI = 0.32–1.35 p = 0.26). Evidence of low to high quality showed the lower RR of RTX in other AEs, but not in infusion-related AEs. Strategies to handle AEs focused on symptomatic treatments. Conclusions: RTX is mostly safer than other immunosuppressants in NMOSD: the incidence of RTX-associated AEs was not high, and when present, the AEs were usually mild or moderate and could be well controlled. Given its efficacy and safety, RTX could be recommended as a first-line treatment for NMOSD.

show abstract

Section: Methodsmentioning

confidence: 92%

Adverse events of rituximab in neuromyelitis optica spectrum disorder: a systematic review and meta-analysis

Wang

Zhou

et al. 2021

Ther Adv Neurol Disord

View full text Add to dashboard Cite

show abstract

“…Another condition to rule out, if alterations of calcium balance are not dependent on gluten toxicity, is sarcoidosis [ 69 ]. It was recently reported by a systematic review and meta-analysis that the risk of sarcoidosis in CD patients is higher than subjects without CD with a pooled OR higher than 7 [ 70 ].…”

Section: When Is It Correct To Supplement Vitamin D In Cd Patients?mentioning

confidence: 99%

The Effect of a Gluten-Free Diet on Vitamin D Metabolism in Celiac Disease: The State of the Art

Miceli

Mengoli

et al. 2023

Metabolites

View full text Add to dashboard Cite

Celiac disease is a chronic autoimmune disorder involving the small intestine, characterized by villous atrophy, crypt hyperplasia and an increase in intraepithelial lymphocytes. Due to both calcium malabsorption and immune activation, a high prevalence of bone mass derangement is evident in this condition, regardless of the presence of overt malabsorption. Alterations of mineral metabolism are also frequently described, and in this review, the modifications of serum levels of vitamin D are analyzed, according to the available literature on this topic. In untreated patients, secondary hyperparathyroidism is responsible for the hyperconversion of 25-vitamin D into 1,25-vitamin D making mandatory the determination of serum levels of both vitamin metabolites to avoid a wrong diagnosis of vitamin D deficit. A gluten-free diet allows for a normalization of bone and mineral metabolism, reverting these abnormalities and raising some doubts on the need for vitamin supplementation in all the patients. Data available do not support this wide indication, and a complete evaluation of bone and mineral metabolism should be performed to select patients who need this therapeutic approach.

show abstract

“…65 Case reports of various dermatologic conditions including sarcoidosis, vitiligo, alopecia areata, lichen planus, dermatomyositis, pyoderma gangrenosum, erythema nodosum, leukocytoclastic vasculitis, linear IgA bullous dermatosis, and aphthous ulcerations have reportedly improved with a gluten-free diet; however, this should not be used as primary therapy in patients without celiac disease. [66][67][68][69][70][71] Because gluten-free diets can be expensive and challenging to follow, a formal assessment for celiac disease should be considered before recommendation of this dietary intervention.…”

Section: Gluten-free Dietmentioning

confidence: 99%

Reexamining the Role of Diet in Dermatology

Svoboda¹,

Christopher²,

Shields³

2021

Cutis

View full text Add to dashboard Cite

Patients are increasingly interested in dietary modifications that may influence skin appearance and aid in the treatment of cutaneous disease.• Although evidence-based dietary recommendations currently are limited, it is important for dermatologists to be aware of the varied and nuanced dietary interventions employed by patients.• There remains a lack of randomized controlled trials assessing the efficacy of various dietary interventions in the dermatologic setting.

show abstract

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

Cited by 15 publications

References 35 publications

Adverse events of rituximab in neuromyelitis optica spectrum disorder: a systematic review and meta-analysis

Adverse events of rituximab in neuromyelitis optica spectrum disorder: a systematic review and meta-analysis

The Effect of a Gluten-Free Diet on Vitamin D Metabolism in Celiac Disease: The State of the Art

Reexamining the Role of Diet in Dermatology

Contact Info

Product

Resources

About