Sarcoidosis and Chronic Hepatic Disease

Maddrey, W. C.; Johns, Carol J.; Boitnott, John K.; Iber, Frank L.

doi:10.1097/00005792-197009000-00002

Cited by 162 publications

(12 citation statements)

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“…In this case, full investigation failed to show any specific cause for the granulomata and they are therefore classified as hepatic granulomata of unknown cause. The most common causes of hepatic granulomata are sarcoidosis and (Vilinskas et al 1970, Maddrey et al 1970. We have seen this case and one other, making a total of 23.…”

Section: Discussionmentioning

confidence: 66%

Granulomatous Liver Disease and Portal Hypertension

Ja¹

1973

Proceedings of the Royal Society of Medicine

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Section: Discussionmentioning

confidence: 66%

Granulomatous Liver Disease and Portal Hypertension

Ja¹

1973

Proceedings of the Royal Society of Medicine

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“…Patients with sarcoidosis frequently have higher titers of autoantibodies than healthy individuals [27][28][29]. Several autoantibodies, including anti-mitochondrial, anti-nuclear, anti-double stranded DNA, anti-citrullinated cyclic peptide, rheumatoid factor, antivimentin, and anti-negative elongation factor E, have been detected in sarcoidosis [27][28][29][30][31][32][33][34]. To the best of our knowledge, no previous study has reported anti-gAChR antibodies in sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Association between neurosarcoidosis with autonomic dysfunction and anti-ganglionic acetylcholine receptor antibodies

et al. 2021

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Objective To determine whether autonomic dysfunction in neurosarcoidosis is associated with anti-ganglionic acetylcholine receptor (gAChR) antibodies, which are detected in autoimmune autonomic ganglionopathy. Methods We retrospectively extracted cases of sarcoidosis from 1787 serum samples of 1,381 patients between 2012 and 2018. Anti-gAChR antibodies against the α3 and β4 subunit were measured by luciferase immunoprecipitation to confirm the clinical features of each case. We summarized literature reviews of neurosarcoidosis with severe dysautonomia to identify relevant clinical features and outcomes. Results We extracted three new cases of neurosarcoidosis with severe dysautonomia, among which two were positive for anti-gAChR antibodies: Case 1 was positive for antibodies against the β4 subunit, and Case 2 was positive for antibodies against both the α3 and β4 subunits. We reviewed the cases of 15 patients with neurosarcoidosis and severe dysautonomia, including the three cases presented herein. Orthostatic hypotension and orthostatic intolerance were the most common symptoms. Among the various types of neuropathy, small fiber neuropathy (SFN) was the most prevalent, with seven of nine cases exhibiting definite SFN. Six of eight cases had impaired postganglionic fibers, of which the present three cases revealed abnormality of 123I-MIBG myocardial scintigraphy. Of the 11 cases, 10 were responsive to immunotherapy, except one seropositive case (Case 2). Conclusions The presence of gAChR antibodies may constitute one of the mechanisms by which dysautonomia arises in neurosarcoidosis.

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“…Similar results were obtained in 2005 when examining patients with sarcoidosis and primary biliary cirrhosis. The authors find it difficult to name the underlying cause of an autoimmune response because the presence of antimitochondrial antibodies is characteristic of autoimmune liver damage (75)(76)(77).…”

Section: Humoral Immunity: Antibody-mediated Reactions In Sarcoidosismentioning

confidence: 99%

Sarcoidosis as an Autoimmune Disease

et al. 2020

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Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and "classic" autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.

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Sarcoidosis and Chronic Hepatic Disease

Cited by 162 publications

References 0 publications

Granulomatous Liver Disease and Portal Hypertension

Granulomatous Liver Disease and Portal Hypertension

Association between neurosarcoidosis with autonomic dysfunction and anti-ganglionic acetylcholine receptor antibodies

Sarcoidosis as an Autoimmune Disease

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